Cotrimxazon 960 medicine for infections (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Sulfamethoxazole, trimethoprim
Ingredient Cuu Long Pharmaceutical Joint Stock Company (Pharimexco)

Ingredient

Composition information	Content
Sulfamethoxazole	800mg
Trimethoprim	160mg

Uses

Indications

Cotrimxazon 960 drugs are indicated in the following cases:

Urinary tract infections: infection of the lower urinary tract bacteria, chronic urinary tract infections, recurrence in adult women, prostatitis infections. increase). sulfamethoxazole (5 parts) and trimethoprim (1 part). Sulfamethoxazole is a sulfonamide, inhibiting the competition of bacterial folic acid synthesis. Trimethoprim is a derivative of pyrimidine, inhibiting enzyme specific enzyme dihydrofolate reductase of bacteria.

Combining Trimethoprim and Sulfamethoxazol so that inhibits two consecutive stages of folic acid metabolism, thus effectively inhibits the synthesis of purine, thymine and finally DNA of bacteria. Serial inhibition has bactericidal effects. This co -mechanism also resists the growth of anti -drug bacteria and makes the drug work even when bacteria resist each ingredient of the drug.

The optimal effect against most microorganisms is seen in the ratio of 1 part of trimethoprim with 20 parts of sulfamethoxazole. Cotrimxazon 960 is coordinated with a ratio of 1: 5, due to the pharmacokinetic difference of two drugs, so in the body the peak concentration ratio is approximately 1:20. However, it is unclear whether the drug can achieve the optimal rate in all positions, and if both drugs achieve the concentration of treatment, the contribution of the syllable to the effect of cotrimxazon In Vivo is still unclear. The following microorganisms are often sensitive to drugs: E. Coli, Klebsiella Sp. Sonnei, Pneumocystis Carinii.

Cotrimxazon 960 has a few effects on Plasmodium falciparum and toxoplasma gondii.

Micro -anti -drug microorganisms: Enterococcus, pseudomonas, campylobacter, anaerobic bacteria, brain tissue, gonorrhea, Mycoplasma.

Dynamic pharmacokinetics

After drinking, both trimethoprim and sulfamethoxazole are quickly absorbed and highly available. After 2 -hour taken at a dose of 800 mg of sulfamethoxazole and 160 mg trimethoprim, the average serum concentration of Trimethoprim is 2.5 mg/l and of sulfamethoxazole is 40–50 mg/l. The stable concentration of Trimethoprim is 4–5 mg/l, of sulfamethoxazole is 100 mg/l after 2–3 days of treatment with 2 doses per day.

Trimethoprim's waste sale time is 9–10 hours, of sulfamethoxazole is 11 hours. So for 12 hours apart is appropriate. 1: 5 ratio between trimethoprim and sulfamethoxazole is most suitable for tablets. However, in serum, this ratio is 1:20 by Trimethoprim diffuse better out of the blood vessels, entering the tissues.

Trimethoprim goes into tissues and secretions better than sulfamethoxazole. The concentration of drugs in urine is 150 times higher than the serum concentration.

Before taking Cotrimxazon 960 medicine for infections (10 blisters x 10 tablets)

How to use

cotrimxazon 960 drugs for oral.

Dosage

Dosage for urinary tract infections

Inhumantic urinary tract infections:

Adults: 1 capsule, 12 hours apart, for 10 days. Or 1 single dose: 2 tablets. But the minimum treatment in 3 or 7 days seems more effective.

Children: 8 mg trimethoprim/kg + 40 mg sulfamethoxazole/kg, divided into 2 times, 12 hours apart, for 10 days.

Chronic chronic urinary tract infection (adult female):

Low doses (200 mg of sulfamethoxazole + 40 mg trimethoprim per day, or an amount of 2–4 times the dose, drink 1 or 2 times per week) proved to be effective, reducing the number of recurrence.

Dosage for respiratory infections

Sacomatic chronic bronchitis:

Adults: 1–1.5 capsules 2 times/day x 10 days.

Acute otitis media, acute pneumonia in children: 8 mg trimethoprim/kg + 40 mg sulfamethoxazole/kg for 24 hours, divided into 2 times, 12 hours apart, for 5–10 days.

Sore throat due to streptococcal sore throat: Do not use this medication.

Dosage to treat gastrointestinal infections

dysentery:

Adults: 1 tablet, 12 hours apart, 5 days.

Children: 8 mg trimethoprim/kg + 40 mg sulfamethoxazole/kg for 24 hours, divided into 2 times, 12 hours apart, for 5 days.

pneumoeystis carinii pneumonia:

Children and adults: The recommended dose for patients is identified by Pneumocystis Carinii is 20 mg of trimethoprim/kg + 100 mg sulfamethoxazole/kg for 24 hours, divided evenly 6 hours apart, in 14–21 days.

Patients with renal function: When the kidney function is reduced, the dosage is reduced according to the following table:

Creatinine clearance (ml/min)

Dosage recommended

Common dose

15–30

1/2 of the usual dose

Unused

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Acidification of urine to increase trimethoprim elimination. If there are signs of marrow inhibition, patients need to use leucovorin (folinic acid) 5–15 mg/day until hematoma recovery.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cotrimxazon 9600, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Fever.

digestive: Nausea, vomiting, diarrhea, tongue inflammation.

Skin: itching, foreigner.

Uncommon, 1/1000

Blood: Eosin hypernagus, leukopenia, neutropenia, hemorrhage.

skin: urticaria.

Rare, 1/10000

Body: Anaphylaxis, serum disease.

Blood: huge red blood cell anemia, hemolytic anemia, decreased crane, granulocytosis and all bloody hemorrhage.

Neuroscope: Aseptic meningitis.

skin: Poisoned epidermal necrosis (Lyell syndrome), Stevens - Johnson syndrome, diverse erythematosus, angioedema, light sensitivity. liver: jaundice, cholestasis in the liver, liver necrosis.

Metabolism: hyperkalemia, hypoglycemia.

Mental: Illusion. genital - urinary tract: kidney failure, interstitial nephritis, kidney stones.

ears: tinnitus.

Instructions on how to handle ADR

Use folic acid 5–10 mg/immediately can avoid ADR due to folic acid deficiency without reducing antibacterial effects. It should be noted that the body's lack of folic acid is not fully reflected through serum folic acid levels.

Trimethoprim high dose in the treatment of pneumocystis carinii pneumonia increases the potassium but may return to normal. The risk of hyperkalemia also occurs in the common dose and should be considered, especially when used simultaneously other drugs that increase potassium or in the case of renal failure.

Patients need to be instructed to drink enough water to avoid crystallized drugs into gravel. Do not expose to avoid light sensitivity.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cotrimxazon 960 drug contraindicated in the following cases:

Severe kidney failure without monitoring plasma concentrations.

Patients are determined to be disgusted with pink anemia due to folic acid deficiency.

Sensitive to sulfonamide or with trimethoprim.

Children under 2 months of age.

Be cautious when using

impaired renal function, prone to folic acid deficiency such as elderly patients and when using cotrimxazon 960 high doses, dehydration, malnutrition.

Cotrimxazon 960 can cause hemolytic anemia in people with a deficiency of G6PD.

The ability to drive and operate machines

drugs do not affect the driver and operate machinery.

Pregnancy

sulfonamide can cause jaundice in children during the period of birth due to pushing bilirubin from albumin. Because trimethoprim and sulfamethoxazole can hinder folic acid metabolism, the drug is only used during pregnancy when necessary. If you need to take the drug during pregnancy, it is important to use folic acid.

breastfeeding period

Women during breastfeeding must not use cotrimxazon 960. Infants are very sensitive to the poisonous effect of the drug.

Drug interaction

Timultant with diuretics, especially Thiazide, increases the risk of thrombocytopenia in the elderly.

Sulfonamide can inhibit protein and excreted through the kidneys of methotrexate. So reduce elimination and increase the effects of methotrexate.

Cotrimxazon 960 is simultaneously used with Pyrimethamine 25 mg/week, increasing the risk of huge red blood cell anemia.

Phenytoin metabolic inhibitors in the liver, capable of increasing the effect of phenytoin.

Cotrimxazon 960 can extend prothrombin in patients using warfarin.

Storage

In a cool dry place, temperatures below 30 ° C, avoid light.

To be out of reach of children.

Other drugs

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