Coversyl 5mg Servier medicine for hypertension (30 tablets)

Dosage form Box of 30 tablets
Specifications Perindopril Arginine
Ingredient Coronary artery disease, psoriasis, heart failure, high blood pressure

Ingredient

Composition information	Content
Perindopril Arginine	5mg

Uses

indications

Coversyl 5mg drug is indicated in the following cases:

Treatment of hypertension.

Treatment of symptomatic heart failure. heart.

conversion enzyme, or kinase is an expeptidase that helps the conversion of angiotensin I into angiotensin II vasodilators as well as the bradykinin vasodilic chemicals into a non -active heptide.

Enzyme inhibition leads to reduction of angiotensin II in plasma this increases the activity of lenin in plasma and reduces aldosteron secretion.

Because the enzyme is transferred to Bradykinin, the inhibition of the enzyme transferred also leads to the increase in the activity of the locally -circulating Kinin (thus also causes activation of the prostaglandin system). It is possible that this mechanism contributes to the impact of lowering blood pressure and also causes unwanted side effects such as cough.

Perindopril works through metabolites with Perindoprilat activity. Other metabolites do not show the effect of inhibiting enzyme transferring angiotensin in vito.

Pharmacokinetics

absorption

After drinking, Perindopril is absorbed quickly and the peak concentration is reached for 1 hour. The half -life is 1 hour.

Perindopril is a precursor; 27% of the dose is circulating blood in the form of a active Perindoprilat metabolism. Perindoprilat's peak plasma concentration is achieved within 3-4 hours. Food reduces converts to Perindoprilat, which reduces the bioavailability of the drug, so it is advisable to take a single dose of the day in the morning before meals.

Distribution

The distribution volume is about 0.2 liters/ kg for non -combined Perindoprilat.

The combination of Perindoprilat on plasma proteins is 20%, mainly on the enzyme that changes the angiotensin form, but depends on the concentration.

Elimination

mainly through urine and the half -life of the segment does not combine about 17 hours, leading to stability within 4 days.

Disseatment in elderly, heart failure, kidney failure.

Dynamic may change in patients with liver failure, but the amount of Perindoprilat produces does not decrease and therefore does not need to adjust the dose.

Before taking Coversyl 5mg Servier medicine for hypertension (30 tablets)

How to use

Coversyl 5mg oral medicine, swallow pills with a cup of water, preferably at a certain hour before breakfast.

Dosage

The efficiency and safety of children under 18 years of age has not been established.

Always adhere to the drug's dose.

Dosage in case of hypertension treatment:

Often the starting dose and the maintenance dose are 5 mg daily, in the morning. If necessary, the dose can be increased to 10 mg after a month of treatment. The daily dose of 10 mg is the maximum dose recommended to treat hypertension.

If the patient is over 65 years old, the starting dose is usually 2.5 mg per day. After a month of treatment, the dose can be adjusted to 5 mg daily and then, if necessary, increase the dose to 10 mg daily.

Dosage in case of symptomatic heart failure:

The starting dose is 2.5 mg per day. After 2 weeks of treatment, the dose can be increased to 5 mg daily. This is also the maximum recommended dose to treat heart failure.

Dosage in case of stable coronary artery treatment:

Often the starting dose is 5 mg daily. After 2 weeks of treatment, the dose can be increased to 10 mg daily. This is also the maximum dose recommended for this indication.

If the patient is over 65 years old, the starting dose is usually 2.5 mg per day. After 1 week of treatment, the dose can be increased to 5 mg daily and then 1 week, increasing to 10 mg daily.

Dose adjustment in patients with renal failure:

Coversyl dose in kidney failure patients should be adjusted based on creatinine clearance as in the table below:

Creatinine clearance (ml/minute)

recommended doses

Clcr ≥ 60

5 mg/day CLCR 2.5 mg every 2 days

No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Management: intravenously 0.9%, if patients lower blood pressure should hold the patient in the posture. If possible, consider Angiotensin II transmission or intravenous intravenous. Perindopril may be removed from circulation by dialysis. The pacemaker is used in case of anti -treatment heart rate.

What to do when forgetting a dose? However, if you forget to use Coversyl, use the medicine as every day on the next day. Do not use double doses to compensate for the medicine you have forgotten.

Side Effects

When using CoverSyl 5 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

neurological disorders: dizziness, headache, abnormalities, dizziness, visual disorders.

Respiratory disorders: cough, shortness of breath.

Gastrointestinal disorders: abdominal pain, constipation, diarrhea, loss of taste, nausea, vomiting.

Skin and tissue disorders: itching, external rash.

musculoskeletal and connective tissue disorders: cramps.

Uncommon, 1/1000

Bloody and lymphatic disorders: leukemia.

Metabolic and nutritious disorders: Hypoglycemia, hyperkalemia (recovery when stopping the drug), hypoglyc sodium.

Mental disorders: mood disorders, sleep disorders.

Neurological disorders: Dreaming, fainting.

Respiratory disorders: bronchial spasm.

Skin and tissue disorders: light sensitivity, skin burns on the skin, severe psoriasis, polymorphic erythema.

musculoskeletal disorders and connective tissue: joint pain, muscle pain.

Kidney disorders and excretion: impaired renal function.

Very rare

Blood disorders and lymphatic systems: granulocytes, or all red blood cells, hemoglobolin reduction and solid red blood cell volume, leukopenia, neutropenia.

neurological disorders: confusing.

Respiratory disorders: Eosin leukemia pneumonia, rhinitis.

Gastrointestinal disorders: pancreatitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Coversyl 5 mg contraindicated drug in the following cases:

Hypersensitivity to the active ingredients or any ingredients of the drug, or any other transferred enzyme inhibitors. Aliskiren in patients with diabetes or renal failure (GFR Be cautious when using

Stable coronary artery disease has an unstable angina that appears in the first month when treating with Perindopril, so carefully evaluate the benefits and risks before continuing treatment.

Hypotension: The medications inhibitors can cause hypotension in patients who are being treated with diuretics, a diet of less salt, dance separation, diarrhea , vomiting, or hypertension with heavy blood pressure dependent on renin. Symptomatic hypotension is recorded in patients with heart failure (with renal failure or no), myocardial ischemia, cerebral infarction. These patients need to be closely monitored when they start treatment and dose correction.

If symptoms of hypotension should be placed on their backs and if necessary, the intravenous infusion of 0.9%sodium chloride solution should be contraindicated, without contraindications at the next dose if the hypotension reaction is transient.

Patients with congestion heart failure if hypotension when using coversyl, the dose should be adjusted or stop using coversyl.

Aortic stenosis and mitral valve/hypertrophic myocardial disease: Precautions when taking the drug.

Renal failure: Creatinine clearance

Patients with hemorrhage: Consider using hemolytic membranes or other types of hypotension.

Race: The enamel inhibitors cause more angel on black people.

Astonious cough is often recorded and out of the drug.

Patients with primary aldosteron increases do not recommend using enzyme inhibitors due to non -response.

The ability to drive and operate machinery

Coversyl does not directly affect the ability to operate machines but there are some symptoms of lower pressure at the beginning of treatment or combination of drugs that affect this ability.

Pregnancy

The use of enzyme inhibitors is not recommended in the first 3 months of pregnancy and contraindications during pregnancy over 3 months.

The period of breastfeeding

due to the lack of information about the use of coversyl during breastfeeding. Coversyl is not recommended to use and should use replacement therapy with safer data.

Interactive drug

Hemoto hyperki: Aliskiren, potassium salt, potassium -keeping diuretics, enzyme inhibitors, Angiotensin II receptor, nonsteroidal anti -inflammatory drugs, heparin, immunosuppressants such as ciclosporin or tacrolimus, trimethoprim.

Contraindicated when using simultaneously:

Aliskiren: In patients with diabetes or kidney failure, the risk of hyperkalemia, impaired renal function and cardiovascular risk, increased risk of death.

Sacubitril/Valsartan: Evaluation risk.

Simultaneous use of enzyme inhibitors and angiotensin receptor inhibitors: increased hypotension, fainting, hyperkalemia, impaired renal function.

Storage

Store drugs at temperatures below 30ºC. Keep the vials close to moisture.

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