Coversyl Plus medicine 5mg/1.25mg Servier treat hypertension (30 tablets)

Dosage form Box of 30 tablets
Specifications Perindopril, indapamide
Ingredient High blood pressure

Ingredient

Composition information	Content
Perindopril	5mg
Indapamide	1.25mg

Uses

Indications

Coversyl Plus drugs are indicated in the following cases:

Treatment of hypertension and is used in the case of high blood pressure (hypertension). chlorosulphamyl).

The rational properties of this drug are a combination of pharmacological properties of each component form forming Coversyl Plus Arginine 5mg/1.25mg, in addition, due to the increase in the effects of the level and the community of the two components mentioned above.

Pharmacological effects

Regarding Coversyl Plus Arginine 5mg/1.25mg

Coversyl Plus Arginine 5mg/1.25mg creates a hypotension effect of the two upper fertilizers.

Related to Perindopril

Perindopril is the inhibitor of enzyme (UCMC), this enzyme transfers angiotensin I to angiotensine II (is vasoconstrictor). In addition, this enzyme stimulates the secretion of Aldosterone from the upper shell and also stimulates Brandykinin's Christmas (which is a vasodilator) to form the hepteptide inactive.

Due to this inhibitor, the result is Perindopril:

Reduce Aldosterone secretion.

Increases plasma renin activity, because Aldosterone no longer has a negative feedback effect.

Reduce the total peripheral resistance that the priority on the blood vessel system of the muscle and the kidneys, without accumulating salt and water or reflected tachycardia when used for a long time.

Anti -hypertension effect is achieved in patients with low or normal renin concentrations. Perindopril is valid for the amazing Perindoprilat metabolites. Other metabolites are no longer active.

perindopril reduces the heart due to:

Stretching vessel may be due to changing the metabolism of prostaglandin: reducing the burden.

Reduce the total peripheral resistance: Reduce the burden.

Studies conducted in patients with heart failure shows:

There is a decrease in the filling pressure of the right and left ventricle.

Reducing the total resistance of peripheral blood vessels.

Increase cardiac supply and improve heart index.

Increase blood flow in the muscle region.

Practice test also improves results.

Related to indapamid

indapamid is a sulfonamid derivative with an indol nucleus, which is related to the reason for the thiazid. Indomamid inhibits the reabsorption of sodium through the dilution of the kidney shell. This drug increases the secretion of sodium and chlorid in the urine and also increases the excretion of a part of potassium and magnesi, thereby increasing the amount of urine secretion and has the effect of lowering blood pressure.

pharmacokinetics

related to Coversyl Plus Arginine 5mg/1.25mg

Perindopril combination with indapamid does not change the pharmacokinetic properties of both drugs compared to when used separately.

Related to Perindopril

After oral use, the absorption of Perindopril grinds out quickly, the maximum concentration is reached within 1 hour. Perindopril's waste sale time in plasma is 1 hour.

Perindopril is a precursor medicine. Twenty -seven percent of Perindopril orally transferred into the blood in the form of active metabolites, Perindoprilat. In addition to the active Perindoprilat, Perindopril also produces 5 other metabolites that are not active.

Perindoprilat's maximum concentration appears within 3 to 4 hours.

Eating food and taking medicine reduces the convert into Perindoprilat. Therefore, to increase bioavailability, Perindopril Arginine should be used by oral once a day in the morning before meals.

I have proven I have a linear relationship between the dose of Perindopril and this concentration in plasma.

The distribution volume is about 0.2L/kg with non -linked perindoprilat. Perindoprilat ratio is linked to plasma proteins of 20%, mainly with angiotensine conversion enzymes, but depends on Perindoprilat concentration.

Perindoprilat is eliminated through urine and the remaining half -life (Life) of the fertilizer is not linked to the protein for 17 hours, creating a stable state lasting for 4 days.

Perindoprilat elimination decreases in elderly people and in patients with heart failure or kidney failure.

The adjustment of the dose in case of renal failure is necessary, and the level of adjustment depends on the degree of renal failure (creatinine clearance).

Perindoprilat clearance is 70ml/min.

Perindoprilat's

dynamics are changed in cirrhosis patients. The clearance of the liver of this substance drops to half. However, the amount of perindoprilat formed is not reduced, and therefore there is no need to adjust the dose.

Related to indapamid

indapamid absorbs quickly and completely through the digestive tract.

Peak plasma concentration in humans is about an hour after drinking indapamid.

Nearly 79% into plasma proteins.

Selling time is about 14 and 24 hours (average 18 hours). Continuous use does not cause accumulation of drugs. Elimination mainly through urine (70% of the dose) and feces (22% of the dose) in the form of active metabolites.

MDAPAMID pharmacokinetics does not change in patients with renal failure.

Before taking Coversyl Plus medicine 5mg/1.25mg Servier treat hypertension (30 tablets)

How to use

Coversyl Plus medicine for oral, should take the medicine in the morning and before meals. Swallowing the whole pill with a cup of water.

Dosage

always drink Coversyl Plus Arginine 5mg/1.25mg in accordance with the doctor's instructions. If anything is unknown, find and ask the doctor or pharmacist immediately.

The usual dose is a tablet once a day. The doctor may decide to change the dose in case of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The most common effect when using overdose is lower blood pressure. If the blood pressure is significantly lowered (the common symptom is dizzy, tired, fainting), lying on the high foot is useful.

What to do when forgetting a dose? However, if you forget to take a remedy for Coversyl Plus Agrinine 5mg/1.25mg, you still use the next dose on time. Do not double the dose to compensate for the forgotten dose.

Side Effects

When using Coversyl Plus, you may experience unwanted effects (ADR).

According to regular levels, unwanted effects include:

Popular ( 1/100)

Headache, dizziness, dizziness, cow ant, market disorders, tinnitus (heard noise in the ears), dizziness due to lower blood pressure, cough, gasping, stomach -intestinal disorders (nausea, vomiting, sore throat, taste disorders, dry mouth, indigestion, diarrhea, constipation), allergic reactions (such as skin rashes, muscle tenses).

Not popular ( 1/1000)

Change mood, sleep disorders, bronchospasm (have a sense of congestion in the chest area, shallow and panting), angioedema (including symptoms such as wheezing, swelling of the face and tongue), urticaria, hemorrhage (with many red spots on the skin), kidney disorders, impotence, sweating.

Very rare (

Confusion, cardiovascular disorders (abnormal heart rate, angina, heart attack), Eosin -preferred pneumonia (a form of rare pneumonia), rhinitis (nose or nose), serious skin rash such as polymorphic erythema.

If you are suffering from systemic lupus erythematosus (a form of glue system disease), this disease may become more serious. Cases of reactions that are too sensitive to light (changing on the skin) after direct contact with sunlight or UVA rays have been reported.

Unknown (frequency cannot be estimated from existing data)

Fainting, abnormal heartbeating heartbeat (Torsade de Pointes), abnormal electrocardiogram, increased liver enzymes.

Renal, liver, or pancreatic disorders and changes in test parameters (blood tests) have also been recorded. The doctor may ask you to do some blood tests to monitor.

In the case of liver failure, brain disease may appear, (serious neurological disorders are seen in case of severe liver failure).

Instructions on how to handle ADR

If you encounter one of the following side effects, stop using Coversyl Plus Arginine 5mg/1.25mg immediately and contact your doctor immediately:

Swelling of the face, lips, mouth, tongue or throat, shortness of breath.

A lot of dizziness or fainting.

abnormal or abnormal heart rate.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Coversyl Plus drugs are contraindicated in the following cases:

allergies to Perindopril or with any other transfer inhibitors, or with any sulphonamid or any other component of Coversyl Plus Arginine 5mg/1.25mg.

There are symptoms such as shortness of breath, swelling of the face or tongue, itching, severe skin rash (this condition is called angioedema) when using enzyme inhibitors (UCMC) or if a family member has these symptoms in any situation.

Severe liver disease or cerebrovative cerebr, degenerative brain disease).

Severe kidney disease or dialysis.

Low or high blood potassium concentration.

Suspected unsatisfactory heart failure (severe water stasis, shortness of breath).

Pregnant for more than 3 months (also avoid using Coversyl Plus Arginine 5mg/1.25mg in the early stages of pregnancy).

breastfeeding.

Be cautious when using

If any of the following conditions occur, it is necessary to immediately notify the physician before using Coversyl Plus Arginine 5mg/1.25mg:

Aortic stenosis (blood artery stenosis from the heart) or hypertrophic myocardial disease (myocardial disease) or kidney artery stenosis (artery stenosis is brought to the kidneys), there are heart or kidney problems, there are liver problems, collagen disease (acacia) (skin disease) such as systemic erythema lupus or stiffness, atherosclerosis, hyper thyroid, hyper thyroid, hyper thyroid disease, hyper thyroid disease, hyper thyroid, hyper thyroid disease) Dedained by a low salt diet or using salt -containing salt substances, taking lithium pills, or potassium diuretics (spironolactone, triamterene) because it should not be combined with these drugs with Coversyl Plus Arginine 5mg/1.25mg.

You also need to notify your doctor if you are pregnant (or may be pregnant). Coversyl plus arginine should not be used in 5mg/1.25mg during the early stages of pregnancy and do not use this drug if pregnant for more than 3 months, because the drug can be serious in pregnancy if used in this period.

You also need to notify the doctor you are using Coversyl Plus Arginine in the following cases: about to use anesthetics or surgery, recently suffered from diarrhea or vomiting, or if you are dehydrated, the LDL filtration is about to be removed (this is how to cholesterol from blood by machine), conduct sensitive solutions to mitigate a mitigation of honey bee and bee testing, which is about to take a medical examination. iodine (chemicals that make the organs such as kidneys, stomach can be observed when projection, X -ray).

Athletes should note that Coversyl Plus Arginine 5mg/1.25mg contains an active substance that can make a positive doping test reaction.

Coversyl Plus Arginine 5mg/1.25mg is not used for children.

The ability to drive and operate machinery

Coversyl Plus Arginine 5mg/1.25mg does not affect alertness when driving and operating machinery, but there are some side effects such as dizziness, weakness related to the phenomenon of reducing blood pressure may occur in some patients. In this case, the ability to drive and operate machinery will be affected.

Pregnancy

consult your doctor if you think you are pregnant (or may be pregnant). The doctor will advise you to stop drinking. Coversyl Plus Arginine 5mg/1.25mg before you get pregnant or as soon as you start pregnant and will guide you to take other pills instead of Coversyl Plus Arginine 5mg/1.25mg.

Do not use Coversyl Plus Arginine 5mg/1.25mg in the early stages of pregnancy and should not be used Coversyl Plus Arginine 5mg/1.25mg during pregnancy for more than 3 months because the drug can be harmful to the fetus if you use it during this period.

Breastfeeding period

Do not use Coversyl Plus Arginine 5mg/1.25mg during breastfeeding.

Alert immediately to the doctor if you are breastfeeding or planning to breastfeed. Meet your doctor right away.

Medicinal interaction

immediately report to the doctor or pharmacist if you are taking or tendon here are taking other drugs, including non -prescription drugs.

Avoid using Coversyl Plus Arginine 5mg/1.25mg with:

Lithium (Treatment of depression).

Potassium diuretics (spironolactone, triamterene), potassium salt.

Some other drugs may affect the treatment results with Coversyl Plus Arginine 5mg/1.25mg. It is necessary to notify the doctor when taking one of the following drugs for special monitoring:

other medications for hypertension.

Procainamide (treatment of heart disorders).

allopurinol (treat gout).

Terfenadine or Astemizole (antihistamine drugs to treat allergies or seasonal fever).

Cortionosteroid, treating many types of diseases including severe asthma, rheumatoid arthritis.

Immunodive inhibitors are used to treat autoimmune or waste diseases (such as eielosporine).

Cancer treatments.

erythromycin injected (an antibiotic).

halofantrine (treatment of some malaria forms).

pentamidine (treatment for pneumonia).

Gold injecting (treating rheumatoid arthritis).

Vincamine (drugs treat cognitive disorders in the elderly, especially dementia).

beepridil (treat angina).

Sultopride (sedative).

Medications for heart disorders (such as quinidine, hydroquinidine, disopyramide, amiodarone, sotalol).

digoxin and other glycosides treat heart disease (heart disease treatment).

Baclofen (Medication for muscle hardening in scattered sclerosis).

Medications for diabetes, such as insulin or metformin.

calcium and calcium supplements.

irritable laxatives (such as Senna acacia).

Non -steroid anti -inflammatory drugs (such as ibuprofen) or high -dose salicylate drugs (such as aspirin).

amphotericin b injected form (serious fungal treatment).

Medicines to treat mental illnesses such as depression, anxiety, schizophrenia ... (such as three -round antidepressants, sedatives).

tetracosactide (Crohn treatment).

Storage

Close the vial to avoid moisture. Store at temperatures below 30 ° C.

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