Crestor 20mg Astrazeneca medicine for hypercholesterolic blood cholesterol (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Rosuvastatin
Ingredient Astra

Ingredient

Composition information	Content
Rosuvastatin	20mg

Uses

Indications

Crestor medicine 20mg is indicated in the following cases:

Crestor 20mg is indicated as a supplementary treatment for diet:

In adult patients with triglycerides.

In the treatment of patients with beta lipoprotein disorders (increased blood lipoprotein III).

Children from 7 to 17 years old and adults with hypertonic hypertension family type.

Bệnh nhi từ 8 đến 17 tuổi bị tăng cholesterol máu gia đình kiểu dị hợp tử (HeFH) nhằm làm giảm lượng cholesterol toàn phần, LDL - cholesterol và ApoB trên trẻ em và thanh thiếu niên 8 đến 17 tuổi bị tăng cholesterol máu gia đình kiểu dị hợp tử nếu những yếu tố sau vẫn còn tồn tại sau khi điều trị bằng chế độ ăn kiêng: LDL - C > 190 mg/dl hay > 160 mg/dl và có tiền sử Families with cardiovascular disease early or have 2 or more risk factors for cardiovascular disease.

To slow down the progression of atherosclerosis in adult patients as part of the treatment strategy to reduce total cholesterol and LDL - C to reach target levels.

Prevention of primary cardiovascular disease

In individuals without clinical evidence of coronary artery disease but at risk of cardiovascular disease, Crestor is indicated:

Reduce the risk of stroke.

Reduce the risk of myocardial infarction.

Reducing the risk of coronary rejection.

Pharmacokology

Mechanism of impact

Rosuvastatin is a selective and competitive inhibitor with HMG - CoA Reductase, is an enzyme catalyst in the conversion process 3 - Hydroxy - 3 - Methylglutaryl Coenzyme A into Meovalonate, a precursor of cholesterol. The main action position of rosuvastatin is the liver, the target organs reduce cholesterol.

Rosuvastatin increases the number of LDL receptors on the surface of the cell in the liver, thus increasing the absorption and catabolism of LDL and inhibits the synthesis of VLDL in the liver, thus reducing VLDL and LDL components.

Pharmaceutical impact

Crestor 20mg reduces increased LDL - cholesterol levels, total cholesterol and triglycerides and increases HDL - cholesterol. The drug also reduces APOB, Non HDL - C, VLDL - C, VLDL - TG and increases APOA - L. Crestor also reduces the ratio of LDL - C/HDL - C, C total/HDL - C, Non HDL - C/HDL - C and APOB/APOA - L.

pharmacokinetic

absorption

Rosuvastatin's peak plasma concentration is about 5 hours after drinking. Absolute bioavailability of 20%.

Distribution

Rosuvastatin widely distributed in the liver is the main place where cholesterol and LDL clearance synthesized - C. The distribution volume of rosuvastatin is about 134 l. About 90% of rosuvastatin combined with plasma proteins, mainly with albumin.

Metabolism

Rosuvastatin is less metabolized (about 10%). In vitro studies on metabolism use liver cells of the person who determines that rosuvastatin is a weak substrate for metabolism through cytochrome P450. The main metabolites are identified as N - Desmethyl and Lactone.

Elimination

About 90% of the dose of rosuvastatin is eliminated in a constant form and about 5% is excreted into a constant urine. Selling time in mineral plasma 19 hours. The sale time does not increase when using a higher dosage. The average plasma clearance is about 50 liters/hour.

Before taking Crestor 20mg Astrazeneca medicine for hypercholesterolic blood cholesterol (2 blisters x 14 tablets)

How to use

Crestor 20mg can be used anytime of the day, during or away from meals.

Dosage

Hyper cholesterol treatment

The recommended starting dose is 5 mg or 10 mg, orally once a day for both patients who have never used Statin groups and patients from the use of HMG - Coa Reductase inhibitors to Crestor. Adjusting the dose to the next dose can be done after 4 weeks if necessary.

Provisions of cardiovascular events

In studies reducing the risk of cardiovascular events, the dose is 20 mg daily.

Children

Hyperized blood cholesterol hyperplation: The recommended dose is 5 - 10 mg/day orally in patients 8 to 10 years old, dose 5-20 mg/day on patients from 10 to 17 years old.

Hyode hyperlested family -type blood cholesterol from: recommended dose is 20 mg/day orally on children from 7 to 17 years old.

Elderly

Should start at a dose of 5 mg once a day in people over 70 years old. No need to adjust the dose due to age.

Patients with renal failure

No dose adjustment in patients with mild to medium renal impairment.

The recommended starting dose for patients with medium renal failure (creatinine clearance

Patients with liver failure

The level of exposure to increased drugs has been recorded in patients with Child - Pugh 8 and 9 scores. In these patients, they should consider evaluating kidney function.

Asian patients

In Asian patients, consider starting with Crestoer 5 mg/day/day due to increased plasma rosuvastatin levels.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? When an overdose of the patient should be treated with symptoms and apply supportive measures when necessary. Should monitor liver function and ck concentration. Blood decomposition may not benefit.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Crestor 20 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system disorders: headache, dizziness.

Disorders of the digestive system: constipation, nausea, abdominal pain.

Disorders of musculoskeletal, connective tissue and bone: muscle pain.

General and on -site disorders: weakness.

Uncommon, 1/1000

Skin and subcutaneous tissue disorders: itching, rash and urticaria.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Crestor medicine 20 mg is contraindicated in the following cases:

Patients with hypersensitivity to rosuvastatin or any excipients of the drug.

Patients with progressive liver disease, including prolonged increased serum transaminase and unknown cause, and when serum transaminase concentration increases more than 3 times the upper limit of normal level (ULN).

Patients with severe renal impairment (creatinine clearance

Patients with muscle disease.

Patients are taking cyclosporin.

Pregnant and lactating women, women may be pregnant without using appropriate contraception.

Caution when using

Effects on the kidneys

proteinuria, recorded in patients with high -dose crestor treatment, especially at 40 mg. It is necessary to assess the kidney function during monitoring of patients who have been treated at a dose of 40 mg.

Muscle effects

The effects on skeletal muscle are recorded in patients treated with crestor at all doses and especially at the dose> 20 mg. If the test is repeated to determine the concentration of CK before treatment is still greater than 5x Uln, it is not advisable to start treatment with Crestor. Crestor should be stopped if the CK concentration increases significantly (> 5x ULN) or the symptoms of severe muscle and daily discomfort. If these symptoms are no more and the CK concentration returns to normal, it is advisable to consider the use of Crestor or use another HMG - Coa Reductase inhibitor at the lowest dose and closely monitor.

influence on the liver

Liver function tests are recommended before treatment and 3 months after starting Crestor. Crestor dose should be stopped if the serum transaminase concentration is three times the upper limit of the normal level.

The ability to drive and operate machinery

Studies to determine the influence of Crestor 20mg on driving capacity and operating the machine has not been performed. When driving or operating the machine, it should be noted that dizziness can occur during treatment.

Pregnancy

Crestor 20mg contraindicated in pregnant women. Women may be pregnant should use appropriate contraceptive measures. If the patient is pregnant during crestor treatment, the drug should be stopped immediately.

Breastfeeding period

Crestor 20mg contraindicated in nursing women. There is no data on milk excretion in humans.

Drug interaction

The effect of drugs on rosuvastatin when used simultaneously:

Transport protein inhibitors: Concomitance Crestor with these shipping protein inhibitors can increase the concentration of rosuvastatin in plasma and increase the risk of muscle pathology.

ciclosporin: Crestor is contraindicated in patients using ciclosporin. Simultaneous use does not affect the plasma concentration of cyclosporin.

Protease inhibitors: Concomitance Protease inhibitors may increase the concentration and contact time of rosuvastatin.

Gemfibrozil and other blood lipid medications: simultaneously use Crestor and Gemfibrozil, increasing 2 times AUC of Rosuvastatin, may occur in pharmacological interactions. Contraindications to simultaneously dose of 40 mg with fibrat.

Ezetimib: simultaneous use of 10 mg and Ezetimib 10 mg, which increases 1.2 AUC value of rosuvastatin in patients with hypercholesterol.

Antacids: simultaneously use crestor with aluminum anti -aluminum and Magnesi Hydroxyd chemes, leading to a reduction in Rosuvastatin levels in 50%mineral plasma.

erythromycin: simultaneous use of Crestor and Erythromycin, resulting in a 20% reduction in AUC value and 30% reduction of CMAX value of rosuvastatin.

Metabolic drugs through cytochrom P450: Rosuvastatin is not a inhibitor or an enzyme induction cytochrome P45O. Therefore, there is no drug interaction due to intermediate metabolism through Cytochrom P450.

Storage

Do not store over 30 ° C. Store in original packaging.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.