Cttprozil 500 Medisun treat acute otitis media, sore throat, tonsillitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefprozil
Ingredient Me Di Sun Pharmaceutical Joint Stock Company - Vietnam

Ingredient

Composition information	Content
Cefprozil	500mg

Uses

indications

Cttprozil drug indicated treatment in the following cases:

used in the treatment of acute otitis media (Aom). II.

On In vitro, Cefprozil inhibits many gram-positive and gram-gram bacteria strains by inhibiting the synthesis of bacterial cells. Under the hydrolysis of beta lactamase, Cefpozil is more stable than Cefaclor.

cefprzil has the following anti -bacterial effects:

Aerobic Gram: Staphylococcus aureus (including beta latamase production strains). Streptococcus Pneumonia, Streptococcus Pyogenes, Enterococcus Dansan, Enterococcus Faecalis, Listeria Monocytogenes, Staphylococcus Epidermidis, Staphylococcus SaproPhyus, Staphylococcus Wamen, Streptoccus Agalactia, Streptococci (Group C, D, F, VA G).

Note: Cefprozil does not work on Enterococcus Faecharm resistance methicilin, and most of the strains of Acinetobacter, Entobacter, Morganella Morganit, PROFEUS VULGARIS. Providencia, Pseudomonas and Serratia Staphylococci Methicillin are considered as Cefpozil resistance.

Aerobic grams: Herophilus Influenza (included in Teta-Lactamase production strains), Moraxella (Barnharrella CatVrhalis (including production strains of Beta Lactamase), Citrobacter Diverus, Escherichia Coli, Klebsiella Phuoria, Nissein Renerhoee Lactamase). Proteus Mirabilis, Salmonella spp., Shigella spp.

Anaerobic bacteria: Prevotella (Bacteroides) Melaninogenicus, Clostridium difficile, Clostridium perfringens, Fusobacterium spp., Peptostreptoccus spp., Propionibacterium acnes.

Medicinal resistance mechanism:

Caphalosporin resistance is the result of many different mechanisms:

Due to the change of bath of the cell membrane for gram-negative bacteria. Cefprozil. Haemophilus Influenza ampicilin is considered as Cefpozil resistance.

Dynamic pharmacokinetics

After drinking, Cefpozil is quickly absorbed through the gastrointestinal tract. Birth in adults is about 90 - 95%, the peak concentration of plasma is about 1.5 hours. Food does not affect the absorption and peak concentration of the drug in plasma, but the time to reach the peak concentration in plasma can be 15 - 45 minutes long.

The drug is allocated into tissue and fluid including gastric juice, middle ear fluid, tonsils, and adenoidual tissue (V.A).

The drug is distributed into milk at low concentrations.

About 35 - 45 % Cefprozil in the circulatory system linked to plasma proteins. The sale time of the drug in plasma is about 1 - 1.4 hours in adults with normal kidney function. Children 6 months to 12 years old, the sale time of the drug in plasma is about 0.94 - 2.1 hours.

Cefprozil is excreted in the urine through the glomerular filtration and excreted the renal tubules about 54 - 70% of the doses of use are eliminated through the urine in the form of unchanged within 24 hours.

Special subjects

Elderly: Leaving clearance and increase AUC.

Semi -waste time of mild drugs in patients with impaired liver function (about 2 hours).

Semi -exhaust time of prolonged drugs (about 5.2 - 5.9 hours) in patients with impaired renal function.

Before taking Cttprozil 500 Medisun treat acute otitis media, sore throat, tonsillitis (1 blister x 10 tablets)

How to use

Cttprozil drugs for oral use. Take whole tablets with lots of water without meals.

Dosage

Children from 2 years old to 12 years old

Skin infection and skin structure: 20 mg/kg every 12 hours in 10 days.

Children from 6 months old to 12 years old

otitis media: 15 mg/kg every 12 hours in 10 days.

Acute sinusitis (for medium and weighing infections of 15 mg/kg every 12 hours in 10 days.

Children ≥ 13 years

Sore throat or tonsillitis: 500 mg x 1 time/day for 10 days.

Respiratory infections:

Acute sinusitis: 250 mg every 12 hours for 10 days. Average to serious to 500 mg every 12 hours in 10 days.

Secondary infections of acute bronchitis: 500 mg every 12 hours for 10 days.

Skin and non -complicated skin and skin infections 250 mg or 500 mg every 12 hours for 10 days.

Adults

Acute otitis media: 500 mg every 12 hours for 10 days.

Sore throat or tonsillitis 500 mg x 1 time/day for 10 days.

Respiratory infections.

acute sinusitis: 250 mg every 12 hours in 10 days. Average to width: 500 mg every 12 hours in 10 days.

Secondary infections of acute bronchitis: 500 mg every 12 hours, for 10 days.

Exacerbats of chronic bronchitis: 500 mg every 12 hours, for 10 days.

Infoliate skin and skin infections: 250 mg or 500 mg every 12 hours, for 10 days.

Patients with liver failure

No dose adjustments for patients with liver failure.

Patients with renal failure

No dose adjustment for patients with creatinine clearance 290 ml/min. In patients with creatinine clearance

Elderly

No need to adjust the dose in the elderly, except for serious liver and kidney function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects (ADR) when using Cttprozil that you may encounter:

Common ADR> 1/100

Digestive: diarrhea, nausea, vomiting, abdominal pain

Liver: Increase alkalin phosphatase and bilirubin.

Allergic reactions: Red rash, urticaria

Blood hoc: leukemia.

Cefprozil treatment stops at allergies or hypersensitivity, need to conduct supportive treatment (ensure the password when and use epinephrin, oxygen, intravenous corticosteroids).

Notify the doctor with unwanted effects when using the drug.

When experiencing side effects of the drug, patients need to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

CTTProzil drugs contraindicated in the following cases:

There is a history of sensitivity to the ingredients of the drug.

Be cautious when using

colitis and diarrhea related to Clostridium Difficele/Botanical

may appear and overdue of bacteria or fungi that are not sensitive when used for prolonged Cefprozil. Appropriate treatment should be taken when superinfection occurs.

Antibacterial treatments that change the normal microorganism households of the colon and may allow the excessive growth of Clostridium difficile bacteria.

C. Difficile (CDI) and diarrhea related to C Difficile, colitis (CDAD), also known as diarrhea related to antibiotics and fake colitis or colitis reported almost with all antibacterial drugs, including ceprozil, and even in the severity of mild diarrhea to colitis that can cause death C. CDAD, C. Difficile production produces hypertoxin associated with increasing the rate of diseases and deaths because they can be resistant to drugs and may require sand surgery to remove colon. Be careful to monitor CDAD if diarrhea develops during or after treatment with the drug. Caution for patients with a history of CDAD that has been reported for at least 2 months or longer after the anti -infection treatment.

If suspected or diagnosed with CDAD, stop using antibiotics without an antique effect against C. difficile as soon as possible use appropriate supportive therapy (such as procession and electrolyte, protein supplement), treatment with anti -bacterial drugs that are resistant to C. difficile (for example, Metronidazol, Vancomycin), and consider the surgical surgery.

Hypersensitivity reaction

Hypersensitivity reactions (such as anaphylaxis, bar theory, red charcoal, Stevens-Johnson syndrome) have been reported when using the drug. If the hypersensitivity reaction occurs, stop immediately CFProzill and take appropriate treatment (eg, using epinephrin, corticosteroids, maintain oxygen and adequate ventilation).

Cross reaction

There is a cross-response part between cephalosporin diseases and other beta-lactam antibiotics, including penicillin and cephamycins.

Before starting treatment, it is necessary to carefully understand the money and the exempted reactions that happened earlier with cephalosporin, penicillin, or other drugs. Avoid use in people who have a hypersensitivity reaction (anaphylaxis) and respectfully in those who have had side effects (for example, rash, fever, eosin monks)

Cautions

Select and use antibacterial drugs:

To reduce the growth of anti -drug bacteria and effective treatment of CFFProzil and other minerals, only used to treat or prevent infections that have been shown by the bacteria sensitive to drugs.

History of gastrointestinal diseases

Celphalosporin is used cautiously in patients with a history of gastrointestinal diseases, especially colitis.

Exoder castor in the film formula can cause abdominal pain and diarrhea when used orally.

Can give Tet CoB’s results directly positively.

The risk of drugs may occur if used in non -bacterial or prolonged chiefs. For people with kidney failure, developing non -sensitive pathogens.

Drug interaction

cefprozil should not be used simultaneously with the following drugs:

Ariroglycosid antibiotics: Kidney toxicity.

Glucose test: may appear fake positive when checking urine glucose.

Probenecid: Increasing AUC (area under the curve) Cefprozil.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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