Cyplosart 50 Remedica treat hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan Kali

Ingredient

Composition information	Content
Losartan Kali	50mg

Uses

indications

Cyplosart 50 drugs treat hypertension: can be used alone or in combination with other anti -hypertension drugs (for example, thiazid diuretics). Losartan should be used for patients who do not tolerate ACE inhibitors.

Pharmacological

Losartan is the first substance of the new anti -hypertension drug group, which is a receptor antagonist (Typo AT1) Angiotensin II.

angiotensin II, made up of angiotensin I in the reaction of the enzyme transferred Angiotensin (ACE) catalyzed, is a strong vascular contract; It is the main hormone that activates the Renin - Angiotensin system, and is an important component in the pathophysiology of hypertension. Angiotensin II also stimulates the adrenal glands of Aldosteron.

Losartan and the main metabolites have a clogged and aldosteron secretion of angiotensin II by preventing Angiotensin II selectively, not attaching to the AT1 receptor in many tissues (for example, blood vessel muscles, adrenal glands). In many tissues, there is also an AT2 receptor but it is unclear whether this receptor has nothing to do with the cardiovascular air conditioner. Both Losartan and the main active metabolites do not show the local dominant effect in the AT1 receptor and have a much larger AT1 receptor affinity (about 1,000 times) than the AT2 receptor. Losartan is a competitive, reversible inhibitor of the AT1 receptor. The metabolic substance has the activity of drugs 10 to 40 times stronger than Losartan, calculated by weight and is a non -competitive, reversible inhibitor of the AT1 receptor. Angiotensin II antagonists also have hemodynamic effects such as ACE inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

Dynamic pharmacokinetics

After drinking, Losartan absorbs well and initially metabolized through the liver thanks to the cytochrom P450 enzymes.Losartan's bioavailability is approximately 33%. About 14% of losartan dose taken into active metabolites, this substance is mostly opposing the Angiotensin II receptor resistance. Half lifetime of Losartan elimination is about 2 hours, and of metabolites about 6 - 9 hours. The average peak concentration of Losartan reaches within 1 hour, and of the metabolites with activity within 3-4 hours.

both Losartan and active metabolites are highly linked to plasma proteins, mainly albumin and they do not pass the blood -brain barrier. Losartan's distribution volume is about 34 liters and of metabolites with an activity of about 12 liters. The total clearance of Losartan's plasma is about 600 ml/minute and of the active metabolites of 50 ml/minute; Their clearance in the kidney corresponds to about 75 ml/min and 25 ml/min. After drinking Losartan marked 14C, collected about 35% of the radioactive in the urine and about 60% in feces.

Before taking Cyplosart 50 Remedica treat hypertension (3 blisters x 10 tablets)

How to use

Cyplosart 50 drugs for oral.

Dosage

Dosage depending on the patient and must be adjusted according to the blood pressure response.

Losartan's starting dose is usually used for adults of 50 mg daily; Lower starting dose may be used (for example, 25 mg per day) for patients who are likely to lose fluid in the heart, including people who are taking diuretics, or liver failure.

Normal maintenance dose is 25 - 100 mg, oral or taken once or divided into 2 times daily. There is no need to change the dose for elderly patients or kidney failure, including people who are hemolysis.

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common expression of overdose is probably hypotension and tachycardia; It is also possible to experience a slow heartbeat due to sympathetic stimulation (vagus nerve). If symptomic hypotension occurs, supportive treatment must be treated. Losartan and active metabolites cannot be removed with blood.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Most of the undesirable effects are light and lost over time.

Common, ADR> 1/100

Cardiovascular: Hypotension. Mechanical.

Cardiovascular: Hypotenary pressure, chest pain, A - V degree II, chest drum, sinus pace, tachycardia, facial edema, blushing. Bruises, Ban Ban. Cow, tremor, bone pain, muscle weakness, joint edema, muscle fibrosis. throat.

Other effects: Sweating.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CYPLOSART 50 contraindications in the following cases:

Too hypersensitivity to Losartan or any ingredients of the preparation.

Be cautious when using

Special monitoring and/or decreased dose in patients dehydrated, diuretic treatment and patients have other factors that can easily lead to hypotension. Patients with kidney stenosis on both sides or one side, only one kidney is also at high risk of unwanted effects (increased creatinine and blood urea) and should be closely monitored in treatment. Patients with liver failure must take lower doses.

The effect of the drug on the ability to drive and operate machinery

cautious while driving and operating machinery.

Use drugs for women during pregnancy and lactation

pregnancy:

Use drugs that directly act on the Renin - Angiotensin system in the middle and last three months of pregnancy can cause less amniotic fluid, hypotension, anuria, urinary discharge, face deformation and death in infants. Although, the use of drugs in the first three months of pregnancy has not seen the risk of the fetus, but when detected pregnancy, it must stop Losartan as soon as possible.

breastfeeding period:

It is unknown whether Losartan is secreted into breast milk, but because many drugs are excreted through human milk and due to the harmful effects for breastfed babies, it is necessary to decide whether to stop breastfeeding or stopping the drug, depending on the importance of the drug for the mother.

Drug interaction

Losartan does not affect the pharmacokinetics of Digoxin oral or intravenously.

Losartan drinks with cimetidine increases the area under the curve (AUC) of Losartan by about 18%, but does not affect the pharmacokinetics of the active metabolites of Losartan.

Losartan oral with phenobarbital reduces about 20% of Losartan and of active metabolites.

There is no pharmacokinetic interaction between losartan and hydrochlorothiazide.

Storage

Store at a temperature not exceeding 30 ° C in the original packaging, avoid moisture and avoid light.

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