Dagocti 0.5mg Medboide medicine for treatment and prevention of the progression of prostate hypertension (30 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Dutasteride
Ingredient Prostate hypertrophy, urination disorders (bedwetting, night urination, urination)

Ingredient

Composition information	Content
Dutasteride	0.5mg

Uses

indications

Dagocti drug is indicated in the following cases:

Treatment and prevention of the progression of benign prostate hyperplasia (Benign Prostatic Hyperplasia). In so, dutasterid can be used for monomers or in combination with alpha tamsulosin. Dutasterid inhibits isoenzyme Alpha - Reductase both Type 1 and Type 2, these are enzymes responsible for turning testosterone into 5 alpha - dihydrotestosterone (DHT). DHT is Androgen that plays the main role in the increase in prostate tissue.

When using dutasterid daily, the maximum effect reduces DHT depending on the dose and is observed for 1-2 weeks of medication.

pharmacokinetic

absorption

Soft gelatin dutasterid capsules are taken orally. After taking a single dose of 0.5 mg, the peak concentration of dutasterid appears after 1 to 3 hours.

Absolute bioavailability in people is about 60% after 2 hours of intravenous infusion. Dutasterid's bioavailability is not affected by food.

Distribution

Pharmacokinetics data after taking single dose and repeat dose shows that dutasterids have a large distribution (300 to 500 l).

dutasterid is highly linked to plasma proteins (> 99.5%).

Metabolism

dutasterid is metabolized by the cytochrome p450 isoenzyme in people into two auxiliary metabolites in the form of monohydroxylate, but is not metabolized by CYP1A2, CYP2C9, CYP2C19 or CYP2D6.

Elimination

After taking dutasterids 0.5 mg/day to achieve a stable concentration in humans, 1.0% to 15.4% (average 5.4%) The oral dose is excreted in the feces as dutasterid. The rest is metabolized into the feces as the form of 4 main metabolites (with a ratio of 39%, 21%, 7%and 7%) and auxiliary metabolites (less than 5%per substance).

Only a very small amount of dutasterid (less than 0.1% of the dose) is found in urine.

Before taking Dagocti 0.5mg Medboide medicine for treatment and prevention of the progression of prostate hypertension (30 tablets)

How to use

should swallow the principle, do not chew or open the cyst because contact with the contained in the follicle can cause irritation of the oral mucosa.

dutasterid can be taken in or outside meals.

Dosage

Dutasterid's recommended dose is a capsule (0.5 mg) orally once daily.

Although it is possible to see early response, it may be necessary to treat at least 6 months to be able to assess whether or not to meet the desired treatment.

To treat benign hypertension, dutasterid can be used for monomers or in combination with alpha tamsulosin (0.4 mg).

kidney failure

There has been no research on the effects of kidney failure on dutasterid pharmacokinetics. However, there is no need to adjust the dutasterid dose in patients with renal failure.

Hepatic failure

There has been no research on the effects of liver failure on dynamic pharmacokinetics of dutasterid.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Dagocti, you may experience unwanted effects (ADR).

Rare, 1/10000

Feather and hair: hair loss (mainly hair loss), hairy hair.

Very rare, ADR

Systemic: allergic reactions, including rash, itching, urticaria, localized edema and veins.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dagocti drugs contraindicated in the following cases:

Patients are known to be hypersensitivity to dutasterid, with other inhibitors 5 - Alpha - Reductase or any component of the preparation.

Contraindicated dutasterid for women and children.

Be cautious when using

dutasterid is absorbed through the skin, so women and children must avoid contact with broken capsules. If contact with capsules broke, should wash the contact with soap and water immediately.

There has been no research on the effects of liver failure on Dutasterid's pharmacokinetics. Dutasterid should be used with caution in patients with dutasterid liver disease widely metabolized and has a sale time of 3 to 5 weeks.

affects the prostate antigen (PSA - Prostate Specific Atigen) and detect prostate cancer. Rectal examination should be performed by fingers as well as other assessments to detect prostate cancer before using dutasterid and then should be checked periodically. The concentration of prostate -specific antigen in the serum (PSA) is an important component in the screening process to detect prostate cancer. Dutasterid causes an average reduction in PSA in serum by about 50% after 6 months of treatment.

Powering and operating machinery

Based on Dutasterid's pharmacokinetics and pharmacokinetics, dutasterid treatment does not affect the ability to drive or operate machinery.

Pregnancy

Not used for pregnant women.

Breastfeeding period

Not used for breastfeeding women.

Medicinal interaction

In vitro transformation studies show that dutasterids are metabolized by isenzyme CYP3A4 of cytochrome P450 in humans. Therefore dutasteride concentration may increase when there is the presence of CYP3A4 inhibitors.

Database of phase II shows a decrease in dutasteride clearance when used simultaneously with CYP3A4 inhibitors such as Verapamil (37%) and Diltiazem (44%). In contrast, no reduction of clearance when using dutasterid and amlodipine or other calcium channel antagonists. Reducing the clearance and thereby increasing dutasterid's body concentration when the presence of CYP3A4 inhibitors is usually not clinical significance due to its wide range of safety (patients have been used up to 10 times the recommended doses in 6 months), so there is no need to adjust the dose.

In vitro, Dutasterid is not metabolized by the isoenzyme CYP1A2, CYP2C9, CYP2C19 and CYP2D6 of Cytochrome P450 in humans.

Dutasterid does not inhibit the drug metabolic enzymes of cytochrome P450 in people in the in vitro test, nor does it touch the isoenzyme CYP1A, CYP2B and CYP3A of Cytochrome P450 in large mice and dogs on In Vivo test.

Storage

Store in a cool dry place, avoid light, temperature not exceeding 30 degrees C.

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