Daikyner treatment of urinary and genital symptoms due to lack of estrogen (3 blisters x 5 tablets)

Dosage form Box of 3 blisters x 5 tablets
Specifications Estriol
Ingredient Ltd Farmaprim

Ingredient

Composition information	Content
Estriol	0.5mg

Uses

indications

Daikyn's drugs are indicated in the following cases:

Treatment of urinary - genital symptoms due to lack of estrogen: vaginal atrophy, dry and itching, painful intercourse, prevent recurrent vaginal and lower urinary tract, urinating and difficult urine. Usually (due to hormonal imbalance). Estriol is a product of Estradiol and Estron's reduction and is detected with high concentrations in urine, especially in pregnant urine. Unlike other estrogen, estriol works short because it is only shortened in the nucleus of endometrial cells, so it is less likely to increase endometrial proliferation when using the recommended daily dose.

Estriol is especially effective in treating symptoms during menopause, preventing vaginal atrophy and manifestations of vascular disorders (hot). Estriol is also used to prevent osteoporosis after menopause. Vaginal atrophy and urinary tract epithelium respond to a short course of Estriol applied to the vagina for a few weeks.

Estriol makes the vaginal epithelium return to normal and thus restores normal and physiological bacteria in the vagina, thus increasing the resistance of the urinary tract against bacterial and inflammation.

Pharmacokinetics

absorption

Set vaginal estriol to ensure optimal effectiveness. Estriol is also absorbed in the general circulation, shown by rapid increase in the concentration of estriol in non -combination form in plasma.

Distribution

Unlike other estrogen, estriol is very little attached to globulin global hormones (SHBG); Most estriol (90%) is attached to plasma albumin. The peak concentration achieved in plasma 1-2 hours after application.

Metabolism

Estriol is metabolized mainly by combined and eliminated in the cycle of intestinal circulation.

Elimination

The final metabolic product is excreted mainly in the form of a combination. Only a small amount (2%) is excreted in feces mainly in the form of an inexperienced estriol.

Before taking Daikyner treatment of urinary and genital symptoms due to lack of estrogen (3 blisters x 5 tablets)

How to use

vaginal placement in the evening.

Dosage

Put 1 capsule/day for the first few weeks, then gradually reduce the dose based on the decline of symptoms until the maintenance dose is reached (1 tablet/time x 2 times/week).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Overdose of estrogen can cause nausea and in women may have bleeding when stopping the drug.

Handling

Vaginal washing (if used by vaginal application), gastric wash (if used by oral).

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Daikyn, you may experience unwanted effects (ADR).

The unwanted effect of estrogen depends on the dose. Most serious ADRs of estrogen therapy first appeared from previous studies with higher dosage estrogen -containing contraceptives than those currently used or hormone replacement drugs for menopausal women.

Common, ADR> 1/100

Digestive: Nausea, vomiting, abdominal distention, abdominal muscles, diarrhea.

Skin: Skin tan.

Systemic: Excessive weight gain or restoration in the body.

Genital urinary: Replace menstruation, loss of menstruation (during use) or amenorrhea (after use), menstrual system, money -like syndrome, candidiasis vaginitis. nerve: headache, migraine, sexual change.

Eye: No contact lens tolerance. Vision disorders.

Uncommon, 1/1 000

Skin: Hairy or hair loss.

nerve: depression, dizziness, dance.

Endocrine metabolism: reducing glucose tolerance, increasing serum triglyceride concentration, folat deficiency.

Rare, ADR

Cardiovascular: Hypertension, blood vessel disease, increased blood clotting.

Cholestasis jaundice, liver tumor, liver function test.

Instructions on how to handle ADR

Nausea and vomiting is the first reaction of estrogen therapy in some people, but this effect may end over time and can be minimized by taking estrogen with food or right before going to bed.

Breasts may be painful and edema, but sometimes this symptom decreases when the dose is reduced.

If hypertension or any symptoms of congested thrombosis, jaundice, severe depression or severe migraine persistent or recurrent, must stop estrogen. Folic acid may be needed if there is a folat deficiency.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Daikynbeart is contraindicated in the following cases:

Too hypersensitivity to estrogen.

Patients suspected or pregnant.

Patients suspected or have cancer dependent estrogen.

Patients with a history of intravenous inflammation, thrombosis or vascular blockage related to the previous estrogen use.

Patients suspected or have breast carcinom.

Unusual and unknown vaginal bleeding.

Be cautious when using

Before starting estrogen therapy, the patient must be examined and asked for a thorough family history and then periodically re -examined. The use of estrogen to treat menopausal disorders must be considered in each specific case, considering the level of disorders, conditions, risks of each patient.

Usually estrogen must not be used for more than a year without the physician. Examination must pay special attention to blood pressure, breast, abdominal organs and sub -frames and make papanicolaou blade. Patients need to examine breasts once a month and be examined by a specialist at least once a year; If the patient is at high risk (age, family factor, with lymph nodes ...), it must be examined more often.

Because vasoconstrictor of thrombosis is at higher risk of postoperative surgery during the use of estrogen therapy, estrogen should be stopped when possible, at least 4 weeks before a surgery at risk of increased blood vessel thrombosis or must be immobile for a long time. Estrogen must be used carefully in people with impaired kidney or liver function or suffering from bone metabolic disorders with hypercalcemia. Estrogen must be used carefully in people with some diseases that may worsen due to retention in the body (eg migraine, heart failure, kidney failure or liver failure).

People with a history of depression must be carefully monitored during the time of using estrogen therapy.

The ability to drive and operate machinery

should be cautious when used for driving objects and operating machinery.

Pregnancy

estrogen can be severe toxic to the fetus when used for pregnant women. Not used during pregnancy.

The period of breastfeeding

Use estrogen for nursing mothers to reduce the number and quality of milk. Must decide or stop breastfeeding or stopping the drug, based on the importance of treatment requirements.

Drug interaction

rifampicin reduces estrogen activity when used simultaneously with estrogen due to liver's microsom enzyme induction. The same effect may occur with other liver enzyme induction drugs (barbiturat, carbamazepin, phenylbutazon, phenytoin and primidon). Estrogen can enhance the anti -inflammatory effect of hydrocortisone and can reduce corticosteroid metabolism in the liver and/or change serum corticosteroid protein. Corticosteroid dose must be adjusted when starting to use estrogen or corticosteroid stops.

Estrogen may reduce anticoagulant oral effects and may need an increase in anticoagulant dose.

Anti -enzyme anti -convulsions, reducing the effect of estrogen. Clinically monitoring and if necessary, the hormone dose must be adjusted in and after stopping anti -convulsions. Oxcarbazepine may reduce the effect of estrogen due to increased estrogen metabolism in the liver. Clinically monitoring and if necessary, the hormone dose must be adjusted in and after stopping oxcarbazepine.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Other drugs

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