Daivobet ointment climbing to treat chronic array psoriasis (15g)

Dosage form Tube x 15g
Specifications Betamethasone, Calcipotriol
Ingredient CLIMB

Ingredient

Composition information	Content
Betamethasone	0.5mg
Calcipotriol	50mcg

Uses

Indications

daivobet is indicated in on -site treatment initially, chronic psoriasis.

Pharmacokic

Calcipotriol is a substance similar to vitamin D. Data in the experiment shows that calcificationriol causes differentiation and preventing the increase of horny cells. This is the basis for psoriasis effects.

Like local corticosteroids, Betamethason dipropionate has anti -inflammatory, anti -itching, vasoconstrictor and immunosuppressive properties, however, the drug does not treat the cause of the disease. The effect of the drug may increase when bandaged due to increased permeability through the horny layer. The ratio of side effects will increase by this reason. In general, the anti -inflammatory mechanism of local steroids is not clear.

The effectiveness of the use of daivobet ointment once a day on the normal psoriasis has been surveyed in a double -clinical clinical study for 4 weeks including 1,603 random patients with normal psoriasis that follows local therapy. The comparison is betamethason dipropionate in ointment, calcableriol in ointment and single ointment, all used once a day. The main response criterion is that the disease is controlled according to the overall assessment of the researcher for the severity of the disease (IGA) at the end of the treatment and reduces the percentage of the severity and psoriasis area (PASI) from the beginning to the end of treatment. For patients whose severity of the disease is initially medium, severe or very severe, "controlled disease" is defined as "no more disease" or "very mild disease", while for patients who have the severity of the initial disease is mild, "controlled disease" is defined as "no longer sick".

% of patients with controlled diseases daivobet ointment (n = 490)

Betamethason

dipropionate

(n = 476)

Calcipotriol

(n = 480)

Ostoplastics

(n = 157)

end of the treatment (week 4) 48.0% 26.3% 16.5% 7.6% The average percentage of percentage in PASI (SD) Daivobet ointment (n = 490)

dipropionate

(n = 476)

Calcipotriol

(n = 480)

Ostoplastics

(n = 157)

ending the treatment (week 4) 71.3 (25.7) 57.2 (29.8) 46.1 (30.6) 22.7 (33.5) Daivobet fat (p

pharmacokinetic pharmacokinetics

Clinical studies, with ointment marked with radio isotope, shows the systemic absorption of Calcipotriol and Betamethasone of Daivobet lower than 1% of the dose (2.5) when applied to normal skin (625cm2) for 12 hours. Apply to the psoriasis area and under the bandage can increase the absorption of corticosteroids.

The damaged skin absorption is approximately 24%. The protein bond is approximately 64%. The time for selling plasma discharge after intravenous injection is from 5 to 6 hours. The sale time after applying skin takes a few days because the drug is still stored in the skin. Betamethasone is metabolized mainly through the liver, but it must also be through the kidneys through a combination with glucuronic acid and sulfate. Excretion through urine and feces.

Before taking Daivobet ointment climbing to treat chronic array psoriasis (15g)

How to use

Apply daivobet to infected skin once a day. The recommended time for treatment is 4 weeks. After this time, it is possible to repeat treatment with the monitoring of health supervision.

Dosage

Maximum daily dose should not exceed 15g, maximum weekly dose should not exceed 100g, and treated skin should not be more than 30% wide body surface.

There is no recommendation for daivobet for children and teenagers under 18 years old.

What to do when overdose?

Over the spot of excessive long -term corticosteroids can inhibit the pituitary and adrenal function, leading to secondary adrenal gland deficiency, usually reversed. In such cases, symptomatic treatment is indicated.

In case of chronic toxic toxicity, corticosteroid treatment is slowly.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Daivobet, you may experience unwanted side effects.

Very common> 1/10

or meet> 1/100 and

not meet> 1/1000 and

rare> 1/10000 and

very rare

DAIVOBET ointment test program up to 2500 patients with approximation 10% of patients are said to have had serious adverse effects. Based on data from clinical trials and drug use on the market, the common adverse effects are itching, rash and burning sensation. The unknown adverse effect is skin pain or irritation, dermatitis, erythema, severe batch of psoriasis, folliculitis and changing skin pigmentation in the topical position. Pustulent psoriasis is an unwanted effect.

The individual adultery effects are listed according to the most reported frequency:

Skin and dysfunction of soft tissue under the skin

Common: itching, rash and hot skin. The following:

Calcipotriol:

Unwanted effects include topical reactions, itching, skin irritation, hot and painful sensations, dry skin, erythema, rash, dermatitis, eczema, psoriasis increased, light sensitive and sensitive reactions including some rare cases of angioed and face edema.

Systemic effects after application can rarely appear causing hypercalcemia - blood or calcium - urine.

betamethason (like diproprionat):

Local reactions may occur after topical medication, especially when applying for atrophy, including skin atrophy, capillary dilatation, skin zebra, folliculitis, hair, dermatitis around the mouth, allergic contact dermatitis, pigment loss and glue acne. When treating psoriasis may be at risk of pustules.

Systemic effects due to topical corticosteroids rarely occur in adults, however, it may be more serious. Inhibiting adrenal glands, cataracts, infections and increased internal pressure may occur, especially after long -term treatment. Systemic effects occur more often when applied under the bandage (plastic, skin folds), when applied on a large scale and during long -term treatment.

When encountering any unwanted effects that have not been recorded in the instruction sheet, report it to your doctor.

Warnings

Before using the drug, you need to read the instructions carefully and refer to the information below.

Contraindicated

daivobet contraindicated with the following cases:

Hypersensitivity to the active ingredient or any excipient. Herpes and chickenpox) Damage to the skin, fungus or skin infection, parasitic infections, manifestations of skin related to tuberculosis or syphilis, red acne, dermatitis around the mouth, regular acne, skin atrophy, striped skin atrophy, fragile skin veins, red acne, ulcers, wounds, itchy psoria pustules.

Caution when using drugs

Patients need to follow the proper use to avoid applying and spreading to the face, mouth and eyes. Need to wash your hands clean after each application.

Do not apply more than 30% of the body surface area.

To minimize the risk of hypercalcemia, it is recommended to thoroughly implement the recommendations for using calcium.

Due to calcorriol, hypercalcemia may occur when the maximum dose exceeds the week (100g). However, calcium concentration in serum quickly returns to normal when stopping treatment.

daivobet contains group III - steroid (strong) and must be avoided with other steroids.

Side effects are seen in relation to the treatment of corticosteroids such as adrenal inhibition or impact on diabetes metabolism can also occur when treated with local corticosteroids due to systemic absorption.

It is necessary to avoid applying on a wide area for the injured and bandaged skin or applying it on the mucous membrane or folding skin because it increases the body absorption of corticosteroids. Do not apply daivobet to the face and genital area, damaged skin. When the lesions become secondary infection areas, it is necessary to treat with anti -bacterial therapy. However, when the infection is worse, it is necessary to stop treating with corticosteroids.

Topicide treatment of corticosteroids for psoriasis can be at risk of puu psoriasis with a whole body or a reverse effect when stopping treatment. Therefore, it is necessary to continue medical supervision after treatment.

Long -term treatment will increase the risk of unwanted and unwanted effects. Treatment should be stopped in case of unwanted effects related to long -term treatment of corticosteroids.

There may be a risk of reversing when stopping long -term treatment with corticosteroids.

There is no experience for using this drug for the scalp. There is no experience when using simultaneously with other psoriasis drugs used on the spot or systemic effects or light treatment.

During the treatment of daivobet, the doctor may recommend that patients limit or avoid excessive sun exposure under natural or artificial light. Only use at the spot Calcipotriol with UV radiation when the doctor considers superior risks.

Daivobet ointment contains butylhydroxytoluen (E321). It can cause local skin reactions (such as contact dermatitis), or irritation to the eye and mucosa.

The ability to drive and operate machinery

No or negligible effect on the ability to drive and operate machinery.

Pregnancy and lactation

Pregnancy

There is no adequate data on use daivobet for pregnant women. Animal studies with glucocorticoids have shown reproductive toxicity, but some epidemiological studies show that there is no congenital abnormalities among newborns of mothers who have treated corticosteroids during pregnancy. The potential risk for pregnant women is uncertain. Therefore, during pregnancy should only use Daivobet when the benefits are out of risk.

Breastfeeding period

betamethason secretes through breast milk but the risk of side effects for newborns does not seem to occur with the treatment. There is no data on the excretion of Calcipotriol into breast milk. Be careful when prescribing daivobet for breastfeeding women. Patients should be instructed not to use daivobet during breastfeeding.

Drug interaction

unknown.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

Do not use overdue drugs in the packaging.

Can be used after opening a 12 -month pipe.

Other drugs

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