Dalacin C 300mg Pfizer treat infections (2 blisters x 8 tablets)

Dosage form Box of 2 blisters x 8 tablets
Specifications Clindamycin
Ingredient Pfizer

Ingredient

Composition information	Content
Clindamycin	300mg

Uses

Indications

Clindamycin has the effect of treating the following infections due to anaerobic bacteria sensitive to drugs or Gram -positive bacteria sensitive to drugs such as streptococci (streptocci), staphylococci (staphylococci), pneumococcal (pneumococci), and sensitive Chlamydia tramydia tramydia tramydia tramydia strains Drugs.

The upper respiratory infections include A-Mianitis, sore throat, sinusitis, otitis media and heat pink disease.

Lower respiratory infections include bronchitis, pneumonia, pleural inflammation and lung abscess.

Skin and soft tissue infections include acne, boils, cellular inflammation, impetigo, abscesses and bacterial infections at the wound. For cases of skin infections and soft tissue such as circles and méaritium (Panaritium) have good response to treatment with clindamycin.

Bone and joint infections include osteomyelitis and bacterial arthritis.

Gynecological infections include endometritis, cellular inflammation, vaginal infections, hose abscesses and ovarian inflammation when combined with an appropriate antibiotic antibiotic gramic bacteria. In the case of cervicitis caused by chlamydia trachomatis, clindamycin treatment is simply a noticeable effect of this bacterium clean.

Infacelation in the abdomen includes peritonitis and abscess in the abdominal cavity when given with a suitable antibiotic Gram-negative bacteria.

Hemorrhage and endocarditis. The effectiveness of clindamycin has been recorded in the treatment of some specific endocarditis cases, when clindamycin at the appropriate concentration can be achieved in serum, which has a bactericidal effect in vitro for being infected.

Dacal infections such as abscesses around the teeth (periodontal abscess) and inflammation around the teeth (periodontitis).

pneumocystis jiroveci pneumonia (previously classified as Pneumocystis Carinii) on AIDS patients. In patients who are not tolerated with or not fully responded to normal treatment, Clindamycin can be used in combination with Primaquin.

Malaria: For this indication, please refer to the diagnostic and treatment instructions for malaria issued by the Ministry of Health.

Preventive treatment for pericarditis in patients sensitive/allergic to penicillin antibiotics.

On In vitro, bacteria sensitive to clindamycin include: B. Melaninogenicus, B. Disiens, B. Bivius, Peptostreptococcus spp.

Pharmacokic

microbiology: Clindamycin is seen as a effect against the isolated strains of the following microorganisms on in vitro.

Gram -positive bacteria, including:

Staphylococcus aureus (staphylococcus). Clindamycin.

Bacteroide species (including bacteroides fragilis and bacteroides melaninogenicus).

Fusobacterium. Peptostreptococcus; Most Clostridium perfringens are sensitive but different species C. Sportogenes and C. Tertium are often resistant to clindamycin.

Need to test for sensitive ability.

Diagonal resistance between Lincomycin and Clindamycin has been proven. The opposition between clindamycin and erythromycin has been proven.

Dynamic pharmacokinetics

Studies of drug concentration in serum on 24 ordinary mature volunteers when taking clindamycin hydrochloride 150mg shows Clindamycin is quickly absorbed after drinking. The average peak concentration in serum 2.50µg/ml is achieved in 45 minutes; The levels of serum concentration reached an average of 1.51µg/ml at 3 hours and 0.70µg/ml at 6 hours. The absorption of an almost complete oral dose (90%), and indicates the drug simultaneously does not significantly change the concentration of drugs in serum; The levels of drug concentration in serum are homogeneous and can be predicted by patients and dose.

Studies on serum drug concentration when using multi -dose clindamycin hydrochloride for up to 14 days shows no evidence of accumulation or change of drug metabolism. Clindamycin's waste time increased slightly in patients with significant renal function. Bloody and peritoneal discharge does not work to remove clindamycin from serum. Clindamycin concentration in serum increases linearly when increasing the dose.

Serum concentration exceeds the minimum inhibitory concentration (mic) of microorganisms for at least 6 hours after using the usual recommended dose. Clindamycin is widely distributed in fluid and body tissues (in both bones). The average biological disposal time is 2.4 hours. About 10% of biological metabolites are eliminated through urine and 3.6% in feces, the rest is eliminated in the form of inactive metabolism. Doses up to 2g Clindamycin per day for 14 days are well tolerated in healthy volunteers, except for the ratio of side effects on the gastrointestinal tract when increasing the dose. Clindamycin concentration into brain fluid is negligible, even when meningitis appears.

After using clindamycin hydrochloride by oral, the selling time increased to about 4 hours (about 3.4 - 5.1 hours) in the elderly compared to 3.2 hours (in about 2.1 - 4.2 hours) in young adults. The level of absorption, however, is not different from age groups and does not need to change the dose for the elderly with normal liver function and renal function (adjusted by age) normal.

Preceptic research:

Cancer toxicity

Long -term studies in animals have not been conducted with clindamycin to assess the potential for cancer.

toxicity causes teratogen

Properties with genome systems have been conducted, including small multiplication tests in rats and reverse Ames Salmonella tests. Both tests give negative results.

Perfect fertility

Studies on the ability to produce rats for oral culverts to 300mg/kg/day (about 1.1 times the largest recommended dose in adults based on Mg/m2) shows no influence on fertility or mating.

In studies on embryo development in mice after using oral medication and embryo development in rats and rabbits after using the medication under the skin, does not observe any progressive toxicity, except in the dosage of toxicity for the mother.

Before taking Dalacin C 300mg Pfizer treat infections (2 blisters x 8 tablets)

How to use

clindamycin hydrochloride capsules used orally. To avoid the ability to stimulate the esophagus should take clindamycin hydrochloride tablets with a full cup of water.

Dosage

Dosage for adults:

Use 300mg/time every 6, 8, 12 hours or 600mg/time every 8, 12 hours.

Dose for the elderly:

Clindamycin pharmacokinetic studies show that there is no clinical significance between young people and the elderly with normal liver function and renal function (adjustment by age) normal after drinking or injecting. Therefore, it is not necessary to adjust the dose in the elderly but normal liver function and renal function (adjustment by age) normal (see section of pharmacokinetic properties).

Dosage for patients with renal failure:

Unnecessary adjustment of clindamycin dose in patients with renal failure.

Dosage for patients with liver failure:

may have to consider adjusting the dose in patients with severe liver failure.

Dosage for special indications:

Hemorrhagic streptococcal infection:

Follow the specified dose above in the dosage section for adults. Should continue treatment for at least 10 days.

Cervical inflammation caused by Chlamydia Trachomatis

Clindamycin hydrochloride oral 600mg, 3 times/day for 10 - 14 days.

pneumocystis jiroveci pneumonia in AIDS patients

Take 300mg Clindamycin hydrochloride every 6 hours or 600mg every 8 hours in 21 days and Primaquin 15 to 30mg once a day for 21 days.

Treatment of A-Mi-danca/acute sore throat

Clindamycin hydrochloride dose capsules 300mg, taken 2 times a day for 10 days.

Treatment of malaria

Clindamycin hydrochloride capsules (oral).

With this indication, please refer to the latest diagnostic and treatment instructions for malaria issued by the Ministry of Health.

Prevention of endocarditis in patients sensitive to penicillin

Clindamycin hydrochloride capsules (oral).

Adults: 600mg 1 hour before surgery; Children: 20mg/kg 1 hour before surgery.

What to do when overdose?

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Dalacin C 300mg, you may experience unwanted side effects.

All undesirable effects are listed according to the classification of Medrra Soc (Medical Dictionary for Regualatory Activities System Organ Class). In each classification section by organ, unwanted effects are presented with the frequency listed in the order of severity gradually decreasing.

Table of unwanted effects

> 1/100 to

Less

> 1/10000 to

Rare> 1/10000 to Unknown frequency (not estimated from available data) Dao. Anaphylaxis, anaphylactic reaction, anaphylactic reaction, hypersensitivity. A steamed

vomiting

esophagitis, esophagus ulcer

jute diverse, itching epidermal necrosis caused by poisoning (ten), Stevens-Johnson syndrome (SJS), Eosin-loving medications and general symptoms (Dress), acute bodies of acne acne acne (AGEP), angioedema, peeling dermatitis, puffiness, measles. General disorders at the place of drug use Pain † †, abscess at the injection site †

annoying at the injection site †

↕DR only applies to oral drugs.

§ Rarely cases have been reported after intravenous injection too fast (see the dose and usage section).

Warnings

Contraindicated

Contraindicated Clindamycin in patients who had previously had a history of allergies to clindamycin or lincycin or any component in the formula.

Caution when taking drugs

Serious hypersensitivity reactions, including serious skin reactions such as drug reactions with eosine hyperlemen and systemic symptoms (dress), Stevens - Johnson syndrome (SJS), epidermal necrolysis caused by poisoning (ten), and foreign acne acne acne (AGEP) Clindamycin. If you have a serious hypersensory reaction or a skin reaction, Clindamycin should be stopped and treated with appropriate therapy (see the contraindication section and unwanted effect section).

Palm colitis is reported with most antibiotics including clindamycin with mild to life -threatening levels. Therefore, it is important to consider diagnosis in patients with signs of diarrhea after antibiotics.

Antibiotic treatment changes the biological system of the colon and can create opportunities for Clostridia to exceed the level. Studies have shown that the toxic produced by Clostridium difficile is the first cause of antibiotic colitis. After determining the initial diagnosis of fake colitis, it is necessary to consider the management of water and electrolytes, protein supplements, and treatment with an antibiotic with clinical effect with colitis due to Clostridium difficile.

Do clindamycin does not diffuse much into the cerebrospinal fluid, should not be used to treat meningitis.

If treatment is prolonged, liver and kidney function should be monitored and monitor the blood formula. Using clindamycin can lead to excessive proliferation of non -sensitive organisms, especially mushrooms.

diarrhea caused by Clostridium difficile (Clostridium Difficile Associated Diarrhea - CDAD) has been reported when used for most antibiotics, including clindamycin, and the level of mild diarrhea to colitis leads to death. Treatment with antibiotics will alter the natural microbiological population of the intestine leading to the excessive development of C. Difficile.

Clostridium difficile produces toxins A and B, contributing to CDAC development. The strains C. Difficile generate many toxins is the cause of increased incidence and death, because these infections can be difficult to treat when using antibiotic therapies and may need to remove the colon. It is necessary to think about CDAD disease in all patients who appear diarrhea after antibacterial use. The medical record should be carefully recorded because the CDAD report has occurred after more than 2 months from antibiotic treatment.

The ability to drive and operate machinery

The effect of clindamycin on driving and operating machinery has not been systematically assessed.

Pregnancy and lactation

Pregnancy

Study toxicity to organ fertility and subcutaneous injection in mice and rabbits does not detect any evidence of decreased fertility or harmful to fetal caused by clindamycin, except for the doses of toxic to the mother. Research on animal fertility does not always predict to meet people.

Clindamycin passes the placenta. After multi -dose use, the use of clindamycin in the whole body route during the second three months and the last three months of pregnancy is not related to increasing the frequency of birth defects. There are no appropriate and well -controlled studies on pregnant women during the first three months of pregnancy.

should only use clindamycin for pregnant women when really necessary.

Breastfeeding period

Clindamycin is reported to be excreted by breast milk with a concentration of 0.7 - 3.8µg/ml. Clindamycin should not be used for breastfeeding women because they can cause serious adverse reactions in babies.

Drug interaction

The antagonistic effect between clindamycin and erythromycin has been noticed in In vitro research. Due to significant clinical significance, these 2 drugs should not be used at the same time. Clindamycin is found to have neuromuscular properties, so it can increase the effects of neurotransmitter. Therefore, be careful in patients who are taking these drugs.

Vitamin K anticoagulant drugs: There have been reports on increased blood clotting test indicators (PT/INR) and/or hemorrhage in patients treated with clindamycin in combination with a anti -anticoagulant drug (such as Warfarin, Acenocoumarol and Fluindione). Therefore, it is necessary to regularly monitor blood clotting results in patients treated with anti -vitamin K drugs.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

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