Dalekine 200mg danapha medicine for epilepsy (4 blisters x 10 tablets)

Dosage form Box of 4 blisters x 10 tablets
Specifications Sodium Valproat
Ingredient Epilepsy, a history of convulsions, convulsions

Ingredient

Composition information	Content
Sodium Valproat	200mg

Uses

indications

Dalekine drugs are indicated in the following cases:

Epilepsy. Mainly used on the central nervous system. The anti-epileptic effect of Valproat probably through neurotransmitter inhibitors is Gama-Aminobutyrie (GABA). Valproat may increase GABA levels due to GABA metabolism inhibitors or increase the activity of GABA after Sinap. Therefore, Valproat can be used in a variety of seizures.

Dynamic pharmacokinetics

Sodium Valproat sodium absorbs quickly after drinking. The peak of Valproat ions in plasma is 1-4 hours after taking the only dose of Valproic acid. When used with food, drugs are more slowly absorbed but does not affect the total absorption.

Half of Valproat in plasma is within 6 - 16 hours. Valproat binds a lot (90%) with plasma proteins at the dose of treatment, but the bond depends on the concentration and decreases when the high value of valproat.

Valproat metabolizes mainly in the liver. The main metabolic lines are glucuronids, oxidation beta in the laptop and oxidize in microsom. The main metabolites formed are: Glucuronid, acid 2 - Propyl - 3 - CETO - Pentanoic and acid 2 - Propyl - hydroxypentanoic. The main elimination line of these metabolites through the urine.

With the same dose, if the patient uses a single Valproat, generally half a life longer and higher concentration than patients using polymer therapy. This is mainly due to other anti -epileptic drugs that cause enzyme induction that increases Valproat clearance.

Before taking Dalekine 200mg danapha medicine for epilepsy (4 blisters x 10 tablets)

How to use

oral medication. Drink whole tablet. Do not chew or break.

Dosage

Used by a doctor's dose or a common dose:

daily dose varies depending on the age and weight of each patient. The optimal dose is determined based on the response of clinical patients. The starting dose is usually 10 - 15 mg/kg/day and gradually increases to the optimal dose. However, if the seizure is not controlled with this dose, it may increase to a dose of 50 mg/kg/day and the patient must be carefully monitored. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? There have been cases of death. Because Valproat is absorbed very quickly, the benefits of gastrointestinal or vomiting depend on the time after taking the drug. Need to apply general support measures, especially need to maintain the amount of urine output.

Naloxon loses the effect of inhibiting the central nervous system of Valproat overdose. But Naloxon can also make Valproate's anti -epilepsy eye, because it may be cautious when using naloxon.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Dalekine, you may experience unwanted effects (ADR).

Hepatic failure leads to death in patients with Valproic acid. This incident usually occurs in the first 6 months of treatment (0.05 - 0.1%).

Common, ADR> 1/100

Systemic: Dizziness, thinking, anorexia with weight or delicious food with weight gain.

Blood: plateletal reduction, platelet aggregation, prolonged bleeding, abnormal coagulation parameters. digestive: indigestion, abdominal pain, nausea, vomiting, diarrhea. liver: Change liver function such as increased transaminase and phosphatase. nerve: Run, sleep or insomnia.

Uncommon, 1/1000

Body: Scattered Red Red Ban.

Endocrine: loss of menstruation, irregular menstruation.

liver: Heavy toxicity to the liver (liver necrosis) for children under 3 years old.

Metabolism: hypernami blood, hypoglycemia.

Mental: Illusion.

Urinary tract: Environment, increase the number of urination.

Other: Hair loss.

Rare, ADR

Body: headache.

Blood: severe platelets, severe leukopenia, bleeding, anemia, eosinophilia, fibrinogen. digestive: pancreatitis, constipation.

Skin: Equipment under the skin.

Liver: Heavy toxicity for liver in children over 3 years old.

Neuroscope: Perception, loss of air conditioning.

Psychiatric: Mental disorder, confusion.

Instructions on how to handle ADR

Notice immediately to the doctor the unwanted effects encountered when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dalekine drugs contraindicated in the following cases:

Acute and chronic hepatitis, family history with severe hepatitis, especially drug hepatitis.

Hypersensitivity to sodium valproate.

Porphyrin metabolism.

Be cautious when using

before taking the drug, the doctor must be examined and monitored regularly.

Notice to the doctor the health status of the patient himself.

Perform biochemical tests on liver function before the beginning of treatment and must be performed periodically for 6 months, especially those with high risks.

In the case of renal failure, it is important to pay attention to the increase in the concentration of the free valproic acid in the serum and then the dose must be reduced.

In children under 3 years old, only Sodium Valproate monatlampon.

Caution in patients with a history of liver disease. Patients use many anti -convulsions, children with congenital metabolic disorders, severe seizures with intellectual growth, and physical enlargement, often may be at high risk.

Need to stop the drug as soon as there is a liver function change, whether suspected or clear.

Valproat excreted partially in the urine in the form of cetonic metabolites, so when testing ceton in the urine, it may be wrong.

Valproot can inhibit the central nervous system, especially when coordinated with other central nervous system inhibitors (such as alcohol), so patients should not participate in dangerous activities such as driving or operating machine.

The ability to drive and operate machinery

Valproat can inhibit the central nervous system, especially when coordinated with other central nervous system inhibitors (such as alcohol), so patients should not participate in dangerous activities such as driving or operating machinery.

Pregnancy

The drug can cause teratogenic. The risk of children with vertebrae is approximately 1-2%, other congenital malformations are face disability, cardiovascular deformities or blood clotting abnormalities. There has been a notice of liver failure leading to death in infants and young children when the mother uses Valproot during pregnancy.

The period of breastfeeding

The drug can enter breast milk with low concentrations (1 - 10% of serum concentration). People do not know if they are harmful to breastfeeding or not, but should stop breastfeeding when the mother takes medication.

Medicinal interaction

Valproot can enhance the effects of central nervous system inhibitors (such as alcohol, benzodiazepin, other anti -dynamic drugs). In the first phase of treatment, it is necessary to determine the plasma concentration of anti -epileptic drugs used simultaneously.

Simultaneous use of Valproat with strong associated drugs with protein (aspirin, carbamazepin, dicoumarol, phenytoin ...) can change the serum valproear levels. Salicylate inhibits metabolism, so it is not used for patients who are using Valproat.

Valproot may increase the concentration of phenobarbital in serum. Primidon is converted into barbiturat, thus also causing such interaction. Valproat may alter the serum phenytoin level: reduces the total phenytoin level in the serum and increases the free phenytoin level compared to phenytoin linked to protein.

Concentrated with Clonazepam can cause a state of constant consciousness in patients with a history of epilepsy in a consciousness. Valproat can affect the concentration of ethosuximid in serum.

When used simultaneously with drugs that affect blood clotting (aspirin, warfarin ...) symptoms of bleeding may occur.

Valproat loses the effect of birth control pills.

Storage

Leave the medicine in a dry, cool, and avoid light.

Building of children.

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