Dalekine 500mg danapha medicine for epilepsy (4 blisters x 10 tablets)

Dosage form Box of 4 blisters x 10 tablets
Specifications Sodium Valproat
Ingredient Epilepsy, a history of convulsions, convulsions

Ingredient

Composition information	Content
Sodium Valproat	500mg

Uses

indications

Dalekine drugs are indicated in the following cases:

Corruption treatment. Use alone or auxiliary in some types of attacks: Awareness of consciousness, muscle seizures, comprehensive seizures (large epilepsy), muscle loss and complex attacks. nursery. The anti -epileptic effect of Valproat probably through neurotransmitter inhibitors is Gamaaminobutyric Acid (GABA). Valproat may increase GABA levels due to GABA metabolism inhibitors or increase the activity of GABA after Sinap. Therefore, Valproat can be used in a variety of seizures.

pharmacokinetic

absorption

Sodium Valproat absorbs quickly after drinking. The concentration of Valproat ion peaks in plasma is 1-4 hours after taking the only dose of Valproic acid. When used with food, drugs are more slowly absorbed but does not affect the total absorption.

Distribution

Valproat binds a lot (90%) with plasma proteins at the dose of treatment, but the bond depends on the concentration and decreases when the high value of valproat.

Metabolism

Valproat specializes in the liver. The main metabolic lines are glucuronids, oxidation beta in mites and oxidation in microsom. The main metabolites formed are: Glucuronid, 2-Propyl-3-Cetanoic acid and 2-Propyl-hydroxypentanoic acids.

Elimination

The main elimination of these metabolites through the urine. The half -life of Valproat in plasma is within 6 - 16 hours. With the same dose, if the patient uses a lone Valproat, generally half a lifetime longer and higher concentration than patients using polymer therapy. This is mainly due to other anti -epileptic drugs that cause enzyme induction that increases Valproat clearance.

Before taking Dalekine 500mg danapha medicine for epilepsy (4 blisters x 10 tablets)

How to use

Take oral use.

Dosage

daily dose varies depending on the age and weight of each patient. The optimal dose is determined based on the response of clinical patients.

The starting dose is usually 0.2ml/kg/day and gradually increases to the optimal dose. The optimal dose is about 0.4 - 0.5ml/kg/day. However, if the seizure is not controlled with this dose, it may be increased to a dose of 0.8ml/kg/day and the patient must be monitoring the kidneys.

Children

The usual dose is 0.5ml/kg/day.

Elderly

as directed by the doctor (the usual dose in the elderly is lower than the adult dose).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There have been cases of death. Because Valproat is absorbed very quickly, the benefits of gastrointestinal or vomiting depend on the time after taking the drug.

Need to apply general support measures, especially need to maintain the amount of urine output. Naloxon loses the effect of inhibiting the central nervous system of Valproat overdose. But Naloxon can also lose the anti -epileptic effect of Valproat, so be cautious when using naloxon.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Dalekine, you may experience unwanted effects (ADR).

Hepatic failure leads to death in patients with Valproic acid. This incident usually occurs in the first 6 months of treatment (0.05 - 0.1%).

Common, ADR> 1/100

Systemic: Dizziness, weakness, anorexia with weight or eat well with weight gain.

Blood: plateletal reduction, platelet aggregation, prolonged bleeding, abnormal coagulation parameters. digestive: indigestion, abdominal pain, nausea, vomiting, diarrhea. liver: Change liver function such as increased transaminase and phosphatase. nerve: Run, sleep or insomnia.

Uncommon, 1/1000

Body: Scattered Red Red Ban.

Endocrine: loss of menstruation, irregular menstruation.

liver: Heavy toxicity to the liver (liver necrosis) for children under 3 years old. Metabolism: increased blood ammonium, hypoglycemia.

Mental: Illusion.

Urinary tract: Environment, increase the number of urination.

Other: Hair loss.

Rare, ADR

Body: headache.

Blood: severe platelets, severe leukopenia, bleeding, anemia, eosinophilia, fibrinogen. digestive: pancreatitis, constipation.

Skin: Equipment under the skin.

Liver: Heavy toxicity for liver in children over 3 years old.

Neurological: Perception, air conditioning.

Mental: Disruptive body, confusion

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dalekine drugs contraindicated in the following cases:

Acute and chronic hepatitis, family history with severe hepatitis, especially drug hepatitis.

Hypersensitivity to sodium valproat.

Porphyrin metabolism disorder

Precautions when using

before taking the drug, the doctor must be examined and monitored regularly.

Notice to the doctor the health status of the patient himself.

Perform biochemical tests on liver function before the beginning of treatment and must be performed periodically for 6 months, especially those with high risks.

In the case of renal failure, it is important to pay attention to the increase in the concentration of the free valproic acid in the serum and then the dose must be reduced.

In children under 3 years old, only Sodium Valproat should be used.

Caution in patients with a history of liver disease. Patients use many anti -convulsions, children with congenital metabolic disorders, severe seizures with intellectual growth, and physical enlargement, often may be at high risk.

It is necessary to stop the drug as soon as there is a change in liver function, whether suspected or clearly manifest.

Valproat excreted partially in the urine in the form of cetonic metabolites, so when testing ceton in the urine, it may be wrong.

Valproot can inhibit the central nervous system, especially when coordinated with other central nervous system inhibitors (such as alcohol), so patients should not participate in dangerous activities such as driving or operating machine.

The ability to drive and operate machinery

Valproat can inhibit the central nervous system, especially when coordinated with other central nervous system inhibitors (such as alcohol), so patients should not participate in dangerous activities such as driving or operating machinery.

Pregnancy

The drug may cause teratogenic. The risk of children with vertebrae is approximately 1-2%, other congenital malformations are face disability, cardiovascular deformities or blood clotting abnormalities. There has been a notice of liver failure leading to death in infants and young children when the mother uses Valproot during pregnancy.

Breastfeeding period

The drug can enter breast milk with low concentrations (1 - 10% of serum concentration). It is not known whether or not the harmful to breastfeeding, but should stop breastfeeding when the mother takes medication.

Medicinal interaction

Valproat can enhance the effects of central nervous system inhibitors (such as alcohol, benzodiazepine, other anti -epileptic drugs). In the first phase of treatment, it is necessary to determine the plasma concentration of anti -epileptic drugs used simultaneously.

Simultaneous use of Valproat with strong associated drugs with protein (aspirin, carbamazepin, dicoumarol, phenytoin ...) can change the serum valproear levels. Salicylate inhibits metabolism, so it is not used for patients who are using Valproat.

Valproot may increase the concentration of phenobarbital in serum. Primidon is converted into barbiturat, thus also causing such interaction. Valproat may alter the serum phenytoin level: reduces the total phenytoin level in the serum and increases the free phenytoin level compared to phenytoin linked to protein.

Concentrated with Clonazepam can cause a state of constant awareness in patients with a history of epilepsy in a consciousness. Valproat can affect the concentration of ethosuximid in the bar.

When used simultaneously with drugs that affect blood clotting (aspirin, warfarin ...) symptoms of bleeding may occur.

Valproat loses the effect of birth control pills.

Storage

Leave the medicine in a cool dry place, avoid light, the temperature does not exceed 30 ° C.

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