Danapha - Trihex 2 treatment supports Parkinson's syndrome, reduces the surgeon syndrome (5 blisters x 20 tablets)

Dosage form Box of 5 blisters x 20 tablets
Specifications Trahexyphenidyl
Ingredient Parkinson

Ingredient

Composition information	Content
Trahexyphenidyl	2mg

Uses

indications

Danapha-Trihex 2 medicine is indicated in the following cases:

Treatment of Parkinson's syndrome support (the forms of vascular sclerosis, after encephalitis or unknown cause). A synthetic amino, Muscarin resistance, Parkinson's syndrome treatment.

As other antacarins, trihexyphenidyl has the effect of inhibiting the nervous system of the Atropin -style peripheral sympathetic, including smooth muscles.

trihexyphenidyl has a direct effect against smooth muscle spasms, mild pupils, reducing saliva secretion and inhibiting vagus nerves of the heart. The exact mechanism of Trihexyphenidyl in Parkinson's syndrome has not been clear, may be due to the sealing of centrifugal pulses and inhibiting the mobility center in the brain.

with low doses, central neurological inhibitors, but with high doses, it stimulates the same as atropine poisoning sign. Currently, Trihexyphenidyl is used to support Levodopa.

For a long time, trienxyphenidyl does not significantly affect blood pressure, respiratory, liver, kidney and bone marrow.

pharmacokinetics

Trihexyphenidyl is well absorbed through the gastrointestinal tract.

The effect begins after 1 hour, the highest in 2-3 hours and lasts 6 - 12 hours. Elimination mainly through urine in non -change form.

Semi -selling time of Trihexyphenidyl varies depending on the testing method. With radioactive immune testing method, the first phase selling time is 5.33 hours, the last phase is 32.7 hours.

Before taking Danapha - Trihex 2 treatment supports Parkinson's syndrome, reduces the surgeon syndrome (5 blisters x 20 tablets)

How to use

Danapha-Trihex 2 medicine is taken orally.

bend 3 times a day at meals, if you need another 4th dose at bedtime. If you cause too dry mouth, should be used before meals or peppermint candy, sugar -free gum or water. It is also possible to use additional saliva replacement drugs. Trihexyphenidyl dose must be carefully adjusted according to the response of each patient, especially the person over 60 years old.

Dosage

Parkinson syndrome

1 mg orally, then 3-5 days to increase 2 mg until 6 - 10 mg per day. Patients with Parkinson's syndrome after encephalitis can be used 12-15 mg/day (can be up to 20 mg/day).

Periodic psychotic disorders

Take 5 - 15 mg/day. The first dose of 1 mg was able to control some reactions, but if the outsider manifest is not controlled within a few hours, it is necessary to increase the dose to meet the requirements. It is also possible to adjust by reducing the dose of the drug that caused these reactions, then adjust the dose of both drugs.

Once controlled these disorders for several days, it is possible to stop using or reducing the dosage of trahexyphenidyl.

If used in combination with levodopa, the dose of 2 drugs must be reduced and adjusted to suit the response and tolerance of each patient.

When trihexyphenidyl is used to replace all or part of other Muscarin antiviral drugs, the doses of trahexyphenidyl should increase gradually, while the other drug should decrease.

Elderly

Should only use Trihexyphenidyl combined with Carbidopa to treat Parkinson for the elderly, maintenance dose 2 - 6 mg/day, divided into small doses.

Children

Not recommended.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The rash may be on the face or upper body.

Symptoms of central nerve stimulation such as restlessness, confusion, hallucinations, paranoia, mental reactions, coordinated eyes, delirium and sometimes convulsions.

Cases of severe overdose, coma, circulatory failure, respiratory failure and death.

Handling

Causes vomiting, gastric lavage, supportive treatment, maintenance of ventilation.

Can use Diazepam to control excessive excitement and seizures.

Anti -arrhythmia is not recommended if the arrhythmia occurs.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Danapha-Trihex 2, you may experience unwanted effects (ADR).

ADRs are mainly excessive acetylcholin resistance. The effects of dry mouth, constipation, blurred vision, dizziness, slight nausea or nervous tension have been reported in 30-50 % of patients. These effects tend to decrease when continuing to use the drug. To help patients adapt to unwanted effects, the initial dose can be used smaller and gradually increasing to effective dose.

Common, ADR> 1/100

Eye: blurred vision due to anti -acetylcholin effect.

Digestive: dry mouth, constipation.

The immune system disorder: Hypersensitivity reaction. The progression of mental disorders may be forced to stop treatment. Can happen suspense. There has been a report on the abuse of Trihexyphenidyl due to its excitement and hallucinations side effects. Impaired temporary and short -term memory function has been reported. - Gut: dry mouth with difficulty swallowing, constipation, nausea, vomiting.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Danapha-Trihex 2 drugs contraindicated in the following cases:

Hypersensitivity to Trihexyphenidyl or any component of the drug.

Caution when using

Elderly and children are easily sensitive to unwanted effects of the drug.

Be cautious when it is hot and when exercising.

Be cautious with people with heart palpitations, prostate hypertrophy, open -angle glaucom, urinary retention.

Regularly checking and evaluating periodic advance room.

The drug contains lactose, so it must be cautious with patients with and metabolic disorders related to lactose.

trihexyphenidyl is associated with the worsening of myasthenia gravis, should avoid or need to use the medication carefully for myasthenia patients.

Except for serious complications, it is recommended to avoid sudden stop use of the drug.

trihexyphenidyl may be abused (based on illusion) if the dose is large enough.

The ability to drive and operate machinery

The drug can cause side effects such as blurred vision, fatigue, dizziness, drowsiness. Therefore, warn patients not to operate machines, work on high or drive while taking the drug.

Pregnancy

has little clinical experience for drugs for pregnant women, not yet recorded harmful effects. Do not use drugs for pregnant women, should only be used when benefits are greater than harmful risks.

Breastfeeding period

whether Trihexyphenidyl is unknown whether or not distributed into breast milk or not. Breastfed babies can be very sensitive to Muscarin resistant drugs. Avoid using trihexyphenidyl when breastfeeding.

Medicinal interaction

Need to monitor carefully when using trihexyphenidyl simultaneously with phenothiazine, clozapine, antihistamine, disopyramid, nefopam and amantadine because it can increase Muscarin -resistant side effects.

The dong -shipping effect has been reported between Trihexyphenidyl and 3 -round antidepressants, which may be due to the impact of the collection at the receptor. This can cause dry mouth, constipation and blurred vision.

In the elderly, there is a risk of urinary retention, acute glaucoma or intestinal paralysis. Monoamine oxidase inhibitors (IMAOS) may interact when used simultaneously with anti -cholinergic drugs including trihexyphenidyl. This can cause dry mouth, blurred vision, urinary retention and constipation. Overall, anti -cholinergic drugs should be used carefully in patients who are taking 3 -round antidepressants or imaos. Trihexyphenidyl dose should be reduced and patient monitoring regularly.

trihexyphenidyl can be opposed to the effects of metoclopramid and domperidon on the stomach function.

trihexyphenidyl reduces the absorption of levodopa, digoxin when used together.

trihexyphenidyl may be opposed to the effects of sympathetic neurological medications.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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