Daskin 81mg Domesco drugs for cardiovascular and cerebral vascular prophylaxis (100 tablets)
Dosage form Box of 100 capsules
Specifications Acetylsalicylic acid
Ingredient Stroke, myocardial infarction, psoriasis, thrombosis
Ingredient
| Composition information | Content |
| Acetylsalicylic acid | 81mg |
Uses
indications
Daspin drugs are indicated in the following cases:
There are two types of COX enzymes: COX-1 is often found in the normal cell tissue of the body (Cox-1 maintains normal stomach mucosa, kidney and platelet function) while COX-2 is mainly seen in the inflammatory position, stimulated to increase prostaglandin caused by cytokin and chemical intermediaries of inflammatory process.
Aspirin's enzyme inhibitor mechanism is different from other nonsteroidal anti -inflammatory drugs. Aspirin associated with both types of COX leading to non -reversible inhibition of this enzyme, so the acting time of aspirin is related to the metabolic cycle of cyclooxygenase. As for other nonsteroidal anti -inflammatory drugs, due to the competition only in the position of the COX, the effect time will be directly related to the time of the drug existed in the body. Aspirin has the effect of inhibiting platelets. The mechanism of COX inhibition of platelets leads to the synthesis of Thromboxan A as a substance that causes platelets.
Platelets are non -nuclei cells, unable to synthesize new COX, so unlike other nonsteroidal anti -inflammatory drugs, aspirin inhibits unfavorable platelet collection, this effect lasts the whole life of platelets (8 - 11 days). Thromboxan A inhibiting effects occur quickly and is not related to serum aspirin levels may be because the COX in platelets have been inactivated before entirely body week. The effect of inhibiting platelets has accumulated properties when using repeated doses.
Aspirin dose 20 - 50 mg/day may almost fully inhibit the thrombocytic thromboxan synthesis for a few days. High doses of 100 - 300 mg may immediately give maximum inhibition effects. Aspirin also inhibits prostaglandin production in the kidneys. Prostaglandin production in the kidneys is less physiologically important to patients with normal kidneys, but plays a very important role in maintaining blood circulation through the kidneys in people with chronic renal failure, heart failure, liver failure, or have plasma volume disorders. In these patients, prostaglandin synthesis effects in the kidneys of aspirin can lead to acute renal failure, water retention and acute heart failure.
Dynamic pharmacokinetics
When taken, aspirin is quickly absorbed from the digestive tract. A part of aspirin is hydrolyzed into salicylate in the intestinal wall. After the circulation, the remaining aspirin also quickly turned into salicylat, but in the first 20 minutes after drinking, aspirin remained in the plasma. Both aspirin and salicylat are active but only aspirin has the effect of inhibiting platelet gates.
Aspirin is attached to plasma proteins with a ratio of 80 - 90% and is widely distributed, with an integral distribution in adults is 170 ml/kg. When the drug concentration in plasma increases, there is a saturated phenomenon of site of plasma proteins and increased distribution. Salicylat is also highly attached to plasma proteins and widely distributed in the body, in breast milk and through the placenta fence.
salicylate is clearly cleared in the liver, with metabolites are salicyluric acid, salicyl phenolic glucuronid, salicylic acyl glucuronid, gentisuric acid. The main metabolites are salicyluric acid and salicylic glucuronide susceptible to saturated and pharmaceutical according to the equation of Michaelis Menten, the remaining metabolites in pharmacokinetics, leading to results in equilibrium state, Salicylate concentration in plasma increases non -linear with the dose.
After the dose of 325 mg aspirin, excretion of the first -order pharmacy and the sale time of salicylate in plasma is about 2-3 hours, with high doses of Aspirin, the sale time can increase to 15 - 30 hours. Salicylate is also eliminated in the form of unchanged urine, the amount of excretion increases according to the dose and depends on the urine pH, about 30% of the dosage excreted through alkaline urine compared to only 2% excreted through acidic urine. Eliminating through the kidneys associated with glomerular filtration processes, actively eliminating through the renal tubules and passive reabsorption through the renal tubules. Salicylate can be discharged through hemorrhage.
Before taking Daskin 81mg Domesco drugs for cardiovascular and cerebral vascular prophylaxis (100 tablets)
How to use
oral medication.
Dosage
Adults:
Clean the stomach by causing vomiting (pay attention to not inhale) or gastric lavage, drinking activated carbon. Monitor and support the necessary functions for life. High fever treatment; Infusion, electrolytes, acid -base imbalance; treatment of ceton accumulation; Keep the concentration of suitable blood glucose.
Monitor sericylate concentration until it is clear that the concentration is decreasing to the point of non -toxic. When taking a large dose of fast release, Salicylate 500 micrograms/ml (50 mg in 100 ml) 2 hours after oral showing a serious poisoning, salicylate concentration above 800 micrograms/ml (80 mg in 100 ml) 2 hours after oral shows can cause death. In addition, it is necessary to monitor for a long time if overdose is large, because the absorption may last long; If the test is performed before drinking 6 hours does not show the Salicylate poisoning concentration, it is necessary to repeat the test.
Causes the urinary tract with urine alkalinization to increase salicylate excretion. However, oral bicarbonate should not be used, as it can increase the absorption of salicylate. If using acetazolamid, it is necessary to carefully consider the risk of serious metabolic acid infection and Salicylate poisoning (caused by increased salicylate penetration into the brain due to metabolic acid infection).
Perform blood transfusion, hematoma, peritoneal clinical, if needed when overdose is serious.
Monitor pulmonary edema and seizures and perform appropriate therapy if needed. Blood transfusion or vitamin K if needed to treat bleeding.
What to do when you forget 1 dose? If you forget to take a dose, drink as soon as you remember. If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose.
Side Effects
Like other drugs, Doaspin can cause side effects, although not all patients encounter. Immediately notify the doctor or pharmacist the unwanted effects when using the drug. If the unwanted effect becomes serious or if you detect the unwanted effect that has not been mentioned in this tutorial, report to your doctor.
Unwanted effects are classified by organ systems. In each group of organ systems, the frequency of unwanted effects is defined as follows: Very common (ADR ≥ 1/10); Common (1/100 ≤ ADR Agencies Frequency Unwanted reactions Common Increased risk of bleeding. Platelet reduction, grain leukopenia, bone marrow failure. Unknown Cases of bleeding with prolonged bleeding time such as nose bleeding, root bleeding. Symptoms may last about 4-8 days after stopping using acetylsalicylic acid. Thus, it may increase the risk of bleeding during surgery. Vomiting blood, black stool or hidden gastrointestinal bleeding can lead to iron deficiency anemia (usually common in higher doses). immune system disorders Rare Hypersensitivity reactions, angels, allergies, anaphylactic reaction including shock. Unknown Hyper uric acid hyperkemis. Rare intracranial hemorrhage. Unknown Headache, dizziness. Unknown. Hearing loss, tinnitus. Rare Bleeding vasculitis. Rare Bronchospasm, asthma attack. Unknown Rhinitis, shortness of breath. Rare menstrual period. Common indigestion Serious gastrointestinal bleeding, nausea, vomiting. Unknown ulcer and puncture of gastric or duodenum, diarrhea. Unknown Hepatic failure Less urticaria. Stevens-Johnson syndrome, Lyell syndrome, hemorrhage, pink button, diverse roses. Unknown. Improving kidney function, salt stasis and water. ADR on the central nervous system can recover completely within 2 to 3 days after stopping the drug. If there are symptoms of dizziness, tinnitus, hearing loss or liver lesions, it is necessary to stop the drug. In the elderly, it is recommended to treat with the lowest aspirin doses and in the shortest possible time. Anaphylactic shock treatment due to aspirin with therapy is the same as when treating acute anaphylactic reactions. Adrenalin is a selective drug and often easily controlled angels and urticaria.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Doaspine drugs are contraindicated in the following cases:
Caution when using
Doaspin tablets are not suitable for fever, anti -inflammatory, analgesic indications.
Recommended use in adults and teenagers aged 16 and over. It is not recommended to use this drug for teenagers/children under 16, unless the benefits are greater than the risk. Salicylic acid can be a contribution factor causing Reye syndrome in some children.
Serious skin reactions, including Stevens-Johnson syndrome, is rarely reported when using acetylsalicylic acid (see unwanted effect section). Doaptin should be stopped when the symptoms are started such as skin rash, mucosal damage, or any other hypersensitivity signs.
Be cautious when treated simultaneously with anticoagulant drugs or when there is another risk of bleeding.
Do not combine aspirin with nonsteroidal anti -inflammatory drugs and glucocorticoids.
When treating people with mild heart failure, kidney disease or liver disease, especially when used simultaneously with diuretics, it is necessary to carefully consider the risk of water retention and the risk of reducing kidney function.
Elderly people may be prone to aspirin poisoning, which is likely to be reduced by renal function. Needs to use lower dose than conventional doses for adults.
Patients with galactose tolerance problems, patients with lapp lactase enzyme deficiency or glucose-galactose abutment should not be taken.
The drug contains tartrazin lake color, which can cause allergic reactions.
The ability to drive and operate machinery
The drug does not affect the ability to operate machinery, driving train, working on high and other cases.
Pregnancy
Low doses (up to 100 mg/day): Clinical studies show that the dose of up to 100 mg/day for limited use in obstetric is safe, but need special monitoring.
100 to 500 mg/day dose: There is no clinical experience in the use of the dose from over 100 mg/day to 500 mg/day. Therefore, the recommendations for the dose of 500 mg/day or more are also applied to this dose.
Dosage of 500 mg/day or more: Prostaglandin synthesis inhibitors can affect harmful to pregnancy and/or the development of the embryo/fetal embryo. Data from epidemiological studies shows an increased risk of miscarriage, heart defects and abdominal cracks after using Prostaglandin synthesis inhibitors in the early stages of pregnancy. The absolute risk of heart defects increases from less than 1% to about 1.5%. This risk is suggested that increased by dose and treatment time.
In animals, the use of prostaglandin synthesis inhibitors increases the likelihood of pregnancy before and after the embryo's nest and increased fetal/fetal death death. In addition, the increase in the proportion of many types of malformations, including the heart, is reported in animals that are used for general inhibitors of prostaglandin during the formation period of the fetus.
During the first 3 months and 3 months between pregnancy, acetylsalicylic acid should not be used if not really necessary. If you need to use acetylsalicylic acid for pregnant women, pregnant in the first 3 months or 3 months, low doses and treatment should be used in the shortest possible time.
During the last 3 months of pregnancy, all Prostaglandin synthesis inhibitors may cause the fetus to suffer the following effects:
The period of breastfeeding. Due to the harmful effects on young children have not been reported so far, the use of short -term recommendations does not require stopping breastfeeding. In case of long -term use and/or higher doses, should stop feeding again. Drug interaction
Food
Simultaneous use of alcohol and acetylsalicylic acid increases the risk of gastrointestinal bleeding.
Using other drugs
Information with your doctor lists all the drugs you are using.
Contraindicated combination with methotrexate (with a dose> 15 mg/week): A combination of methotrexate and acetylsalicylic acid can increase the blood toxicity of methotrexate due to acetylsalicylic acid that reduces the clearance of methotrexate in the kidney. Therefore, contraindicated use of methotrexate (at the dose> 15 mg/week) simultaneously with Daspin 81 mg.
It is not recommended to combine with uric acid hypertrophy, such as Probenecid: salicylate that reverses the effect of probenecid, so it is necessary to avoid combining these drugs. The combination needs to be used carefully or to pay attention
Anticoneal drugs such as Coumarin, Heparin, Warfarin and Phenindion: increase the risk of bleeding due to inhibition of platelet function, damage to the duodenum mucosa and replace oral anticoagulants at positions associated with plasma proteins. Need to monitor bleeding time.
Anti -platelets (such as clopidogrel and dipyridamol) and selective Serotonin recovery inhibitors (SSRIs; such as sertralin or paroxetin): increase the risk of gastrointestinal bleeding.
Diabetes treatments such as sulphonylurea: Salicylic can increase the hypoglycemic effect of sulphonylurea.
Digoxin and lithium: Acetylsalicylic acid reduces the secretion of digoxin and lithium through the kidneys, leading to increased concentration of these two drugs in plasma. It is recommended to monitor plasma concentrations of digoxin and lithium at the beginning and at the end of treatment with acetylsalicylic acid. The dose can be adjusted.
Diuretics and hypertension treatment: NSAID drugs can reduce the anti -hypertension effect of diuretics and other hypertension drugs. Like other NSAID drugs, simultaneous treatment with transferred enzyme inhibitors can increase the risk of acute renal failure.
Diuretics: The risk of acute renal failure due to reduced glomerular filtration through the effect of decreased prostaglandin synthesis. It is recommended that the water rehydration and the patient's renal function monitoring at the beginning of treatment.
ANHYDRASE carbon dioxide (acetazolamid): can lead to serious acidosis and increase the toxicity of the central nervous system.
Systemic corticosteroids: The risk of ulcer and gastrointestinal bleeding may increase when using Salicylic and Corticosteroid acid simultaneously.
methotrexate (with a dose of
Other NSAID drugs: Increasing the risk of ulcer and gastrointestinal bleeding due to the effect of synergies.
ibuprofen: Experimental data shows that ibuprofen can inhibit the effects of low -dose acetylsalicylic acetyls acetylsalicylic acid on platelet collection when using these two drugs simultaneously. However, the limitations of these data and uncertainty about the external external illness of EX Vivo data for clinical situations suggest that it is impossible to conclude firmly about regular and clinical use of ibuprofen, there is no clinical influence that needs to be considered for ibuprofen.
ciclosporin, tacrolimus: simultaneous use of NSAID and Ciclosporin or Tacrolimus drugs may increase the toxicity on the kidneys of ciclosporin and tacrolimus. Kidney function should be monitored when used simultaneously these two drugs with acetylsalicylic acid.
Valproot: There is a report on acetylsalicylic acid reducing the cohesion of valproot with serum albumin, thereby increasing the concentration in the stable state of the free valpress form in plasma.
Phenytoin (anti -epileptic drug): Salicylate reduces phenytoin's cohesion with plasma albumin. This may reduce the total phenytoin concentration in plasma but increase the free phenytoin composition. The concentration is not cohesive and the effect of treatment, not significantly changed.
Antacid drugs will reduce the effects of aspirin.
Basic cavalry substances are iron salts, carbonate and alkaline hydroxides.
Storage
In the dry place, temperatures below 30 ° C, avoiding light.
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