Davibest 50mg Davipharm medicine reduces the symptoms of all forms of depression (30 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Trazodone
Ingredient DAVI

Ingredient

Composition information	Content
Trazodone	50mg

Uses

Indications

Davibest is indicated in cases of treatment that reduces the symptoms of all types of depression, including anxiety.

Pharmacokic

Trazodon is a strong antidepressant. The drug also has anxiety activity. Trazodon hydrochloride is the derivative of trazolopyridine not related to chemicals to 3 -round antidepressants, 4 rounds and other antidepressants. The drug affects the Noradrenalin reabsorption mechanism.

Although the mechanism of action of Trazodon Hydrochorid is unknown, the anti -depression effect of the drug may be related to the stimulation of Noradrenergic because of the absorption preventive mechanism. The effect of reducing anxiety of the drug may be due to central serotonin inhibition.

pharmacokinetic

absorption

Trazodon is absorbed quickly and almost completely from the digestive tract. CMAX in plasma is reached for about 1 hour after taking Trazodon hydrochloride at hunger and 2 hours if taking medicine with food.

Distribution

The distribution of trazodon in tissue and translation in humans has not been determined. Trazodon through animal blood barriers and the concentration of the drug in the brain is higher in plasma within the first 8 hours after drinking. Trazodon associated with plasma protein 85 - 95%.

Metabolism

Trazodon is metabolized in the liver. The metabolic path of Trazodone includes N - oxidation and hydroxylation. Metabolic m - chlorophenylpiperazin is active.

Elimination

trazodon eliminates through urine almost all in the form of metabolites, freedom or complex. Trazodon excretion consists of 2 stages with the last half -life from 5 to 9 hours of trazodon secreted through breast milk.

Before taking Davibest 50mg Davipharm medicine reduces the symptoms of all forms of depression (30 tablets)

How to use

Davibest drugs are used by oral.

Dosage

should take low doses and gradually increase slowly, record clinical response and any signs of intolerance. If you occur drowsiness, use a large dose of the day before going to bed or reducing the dose. Should take the medicine right after the meal.

Adults

The starting dose of 150 mg/day divided 2-3 times orally. May be an additional 50 mg/day after 3-4 days. The maximum dose for outpatient patients shall not exceed 400 mg/day, divided several times. Residential patients (severe depression patients) may take a higher dosage but not exceeding 600 mg/day divided several times.

Maintenance dose

Should use the lowest dose effectively. When achieved fully responded, the dose can be reduced slowly, then adjust the dose depending on the treatment response.

Treatment of adult anxiety

The starting dose of 75 mg/day may increase to 300 mg/day if necessary. Divide many times a day or drink once before going to bed.

Elderly or weakness

Starting dose 100 mg/day. The dose can be increased depending on the effectiveness and tolerance. Do not use more than 300 mg/day.

Children

Do not have enough information about safety when using trazodon for children.

Patients with liver failure, renal failure

Be cautious in patients with liver failure, especially severe liver failure. Monitor regular liver function.

No need to adjust the dose in patients with renal failure, caution with patients with severe renal impairment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? You can use activated carbon and gastric lavage after drinking 1 hour. Monitoring blood pressure, pulse, GCS and symptom support treatment such as seizures, hypotension ...

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

The case of suicide intentions and suicidal behavior has been reported while using trazodon or soon after stopping treatment.

unknown frequency

Blood and lymphatic system: Disorders of hematopoietic disorders (including granulocytes, thrombocytopenia, eosinophilia, leukopenia and anemia).

immune: allergic reactions.

Endocrine: The anti -hormone secretion syndrome is inappropriate.

Metabolism and nutrition: Lower sodium blood, weight loss, eat, increase appetite.

Mental: The intention of suicide or suicide behavior, confusion state, insomnia, disorientation, revival, anxiety, nervousness, excitement (more serious than delusion), delusion, agitation, hallucinations, nightmares, decreased sexual desire, cessation syndrome. Neurological: Serotonin syndrome, convulsions, malignant neuronal syndrome, dizziness, dizziness, headache, drowsiness, unable to rest, reduce reflexes, tremor, blurred vision, memory disorders, muscle vibration, loss of language, abnormalities, muscle disorders, change taste. Heart: arrhythmia (including torsion, chest drum, extra mind, external ventricular ventricular, ventricular tachycardia), slow heartbeat, tachycardia, electrocardiogram abnormal (extending QT).

blood vessels: Hypotenary pressure vertical, hypertension, fainting.

Respiratory, chest and mediastinum: stuffy nose, difficulty worship.

Digestive: Nausea, vomiting, dry mouth, constipation, diarrhea, indigestion, abdominal pain, gastritis, increased salivation, intestinal paralysis. liver - bile: abnormalities of liver function (including jaundice and liver cell damage), bile stasis in the liver.

Skin and subcutaneous tissues: skin rash, itching, increased odor secretion.

muscle and connective tissue: pain in the limb, back pain, muscle aches, joint pain.

Kidney and urinary: urination disorders.

Genital system and breast enrollment: penis.

Body and sugar used: weak, edema, symptoms like influenza, exhaustion, chest pain, fever.

Testing: Increased liver enzyme.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Davibest contraindicated in the following cases:

Hypersensitivity to Trazodon or any ingredients of the drug.

Alcoholic poisoning or poisoning.

Acute myocardial infarction.

Precautions when using

trazodon should be used cautiously in patients with urinary retention related to porphyrin metabolic disorders.

suicide/suicide thoughts and deteriorate the disease: Patients with depression and neurological disorders can see that their depression is worse or the thought of suicide, whether or not to use depression. However, antidepressants may play a role in severe depression and suicide ideas in some patients in the early stages of the treatment process.

Patients who use antidepressants for any indications should be closely monitored to quickly detect signs of more severe illness, suicide intentions and abnormal changes, especially in the first months of drug use, when changing the dose, whether it is increased or decreasing.

Be cautious about dosage and regular monitoring when taking the drug in the following patients:

Epilepsy, avoid sudden increase or decrease in dose.

Patients with liver and kidney failure. Especially cautious when liver failure, kidneys.

Patients with heart disease, such as angina, transmission disorder or atrial block of different levels and recent myocardial infarction.

Hyperthyroidism.

urination disorders, such as prostate hypertrophy, but the disadvantages may not be seen due to the low anti -cholinergic effect of Trazodon.

Patients with acute narrow angle increased, increased pressure in the eyes, although major changes may not be seen due to trazodon's little anti -cholinergic effect.

When jaundice occurs, Trazodon treatment must stop.

Using antidepressants in schizophrenia or other mental disorders can worsen symptoms of mental illness. Paranoid thinking may be increased. During the treatment of Hung - depression with Trazodon, the stage of depression can change to the stage of manic. At that time, Trazodon must be stopped using.

Due to clinical leukemia with symptoms such as flu, sore throat and fever, when the above symptoms should conduct hematology.

Hypotension, including hypotension and fainting, has been reported in patients who are used for trazodon. Concentrated medication to treat hypotension with trazodon may have to reduce the dose of antihypertensive drugs.

Elderly patients are often more sensitive to antidepressants, especially posture hypotension and other anti -cholinergic effects.

When treated with Trazodon, especially for a long time, recommend that the time should be increased from the decrease of the dose to stop the drug to reduce the symptoms of quitting, characterized by nausea, headache and discomfort.

There is no addictive trazodon evidence.

As with other antidepressants, in case of extending QT rarely report when using Trazodon. Be careful when prescribing Trazodon with drug products extending QT. Trazodon should be used carefully in patients with cardiovascular disease including diseases related to the QT range.

Similar to drugs that inhibit Alpha sympathetic effects, Trazodon rarely causes erections. It can be treated with an injection in the cave an alpha - adrenergic substance like adrenalin or metaraminol. However, there are reports of erectile complications due to trazodon that needs surgical intervention or leading to long -term sexual dysfunction. The patient discovered that the response reactions should be discontinued immediately.

Patients with rare genetics galactose, Lapp Lactase deficiency or malposure Glucose Galactose should not be taken.

to be out of reach of children.

The ability to drive and operate machinery

Trazodon has a small or medium impact on the ability to drive and operate machinery. Because the drug has an impact on the central nervous system, the patient should be cautious with the risk of driving operating machinery until it is definitely not sleepy, dizzy, mixed state, or blurred vision.

Pregnancy

trazodon should not be used during pregnancy or only use when the benefits for mothers are superior to the risk of pregnancy.

Breastfeeding period

low breast milk content. However, the content of metabolites through milk is unknown. The risk and benefits should be considered for treatment for breastfeeding women.

Medicinal interaction

can increase the sedative effects of neurological drugs, sleeping pills, sedatives, anti -anxious drugs; The dose should be reduced in the above cases.

The metabolism of depression increases due to the impact on the liver of oral contraceptives, phenytoin, carbamazepin and barbiturat. Metabolism of depression is inhibited by cimetidine and some other mental drugs.

In vitro test shows that Trazodon has the ability to interact with strong CYP3A4 inhibitors such as erythromycin, ketoconazole, iTraconazole, ritonavir, indinavir and nefazodon increases the plasma concentration of Trazodon.

Trazodon can increase the effects of muscle relaxants and volatile anesthesia, so it should be cautious when shared. Trazodon enhances sedative effects of sedatives, including alcohol. Do not use alcohol while in the process of treatment with trazodon.

Triple -round antidepressants: Shock should be avoided due to the risk of interaction causing serotonin syndrome and unwanted effect on the heart.

fluoxetin: rarely occur causing increased plasma concentrations of trazodon.

Monoamine inhibitors oxidase: Do not share imao drugs with trazodon and do not take one within two weeks after stopping the remaining drug.

Phenothiazin, chlorpromazin, fluuphenazin, levomepromazin, perphenazin: can cause serious standing hypotension when used with trazodon.The simultaneous use of trazodon with drugs that extend the QT range may increase the risk of ventricular arrhythmia, including torsion.

wafarin: may cause a change of prothrombin time.

Phenytoin, digoxin: Increased serum concentration of phenytoin and digoxin.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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