DAYGRA 100 ABBOTT medicine for erectile dysfunction (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Sildenafil
Ingredient Glomed

Ingredient

Composition information	Content
Sildenafil	100mg

Uses

Indications

Daygra 100 drugs are indicated in the following cases:

Treatment of erectile dysfunction, is the inability to achieve or maintain erection in men. type 5 (pdes).

The physiological mechanism of the erection that leads to the release of nitric oxidation (NO) in the cave in the process of sexual stimulation.

After that, NO activated Ganylat Cyclase, this enzyme increases the level of CGMP, thereby relaxing blood vessel muscles in the cave form and allowing blood flow to flow.

Sildenafil does not have the effect of direct relaxation on the isolated cave in humans but it increases the effect of NO by inhibiting PDE5, this substance has the effect of decomposing CGMP in the cave. When sexual stimulation causes local release, PDE5 inhibitors because Sildenafil increases CGMP levels in the cave, thereby relaxing smooth muscles and increasing blood flow to the cave.

In the recommended dose, Sildenafil does not work if there is no sexual stimulation.

pharmacokinetic

After taking a dose of Sildenafil, the drug is quickly absorbed with bio -use about 40%. The peak concentration of plasma is achieved within 30 - 120 minutes. The level of absorption decreases when taking medicine with food.

Sildenafil is widely distributed throughout the tissues and about 96% associated with plasma proteins.

The drug is metabolized in the liver mainly by the cytochrom P450 3A4 enzyme. Main metabolites, N-Desmethylsildenafil, also have some effects. The last half life of Sildenafil and N-Desmethyl metabolites is about 4 hours.

Sildenafil is eliminated in the form of metabolites, mainly in stool, and a little in urine. The clearance may be reduced in the elderly and people with liver failure or severe kidney failure.

Before taking DAYGRA 100 ABBOTT medicine for erectile dysfunction (1 blister x 4 tablets)

How to use

take medicine for 1 hour before sex. Do not use more than once a day.

Dosage

Adults:

The usual dose is 50mg/day. The dose can be adjusted according to the patient's response. The maximum dose recommended is 100mg/day.

People over 65 years old:

The starting dose of 25mg.

Hepatogens:

The starting dose of 25mg.

People with kidney failure:

The starting dose of 25mg in people with severe renal failure (creatinine clearance below 30ml/minute).

People who are taking other drugs:

The starting dose must not exceed 25mg/day if you are taking Sildenafil with Cytochrom P450 3A4; Do not use more than 25mg every 48 hours when used with ritonavir; The starting dose of 25mg should be considered in patients to be stable with alpha blockers. Do not use higher doses within 4 hours of alpha blockers due to the risk of hypotension.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Symptoms of overdose may include dizziness, shock, or prolonged erection.

Management:

In case of overdose, standard support measures should be applied. Because Sildenafil is highly connected to plasma proteins and does not be eliminated in urine, renal fertilizer does not increase the clearance of the drug.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Daygra 100, you may experience unwanted effects (ADR).

Unwanted effects are usually just fleeting and mild to moderate. Penis spasticity can also occur. heart.

Instructions on how to handle ADR

Stop using and consulting your doctor if: Heart symptoms (such as dizziness, nausea, and chest pain) during sexual activity, or adverse effects become serious.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Daygra 100 contraindications in the following cases:

Hypersensitivity to any ingredients of the drug.

People who are using nitric oxidants, organic nitrates or organic nitrite. People with severe liver failure, hypotension, new stroke or myocardial infarction, unstable angina, heart failure, retinal disorders such as pigmentitis.

Precautions when using

should diagnose erectile dysfunction and identify potential causes before treatment with Sildenafil. Before the treatment of erectile dysfunction, the doctor should pay attention to the patient's cardiovascular condition, because the risk of cardiovascular disease is associated with sexual activity may occur.

Be cautious in patients with severe liver or kidney failure, and may reduce the dose of Sildenafil as needed.

Be careful when taking the drug for patients with deformations of penile anatomy or hematological disorders that cause penis erection.

Avoid using Sildenafil if there are heart problems that are heavy enough to endanger sex.

Use caution if you have been stroke, life -threatening stroke, hypertension or severe hypotension, heart failure, unstable angina (within 6 months earlier).

Safety and effectiveness of Sildenafil coordination with other erectile dysfunction drugs have not been studied, and these combinations are not recommended.

Use on children: Do not use this drug for children.

Used on the elderly: Due to the decrease in the clearance of Sildenafil in the elderly, the starting dose is lower.

The ability to drive and operate machinery

Those who have been dizzy or visual disorders should not drive or operate dangerous machines.

Pregnancy

Not used.

Breastfeeding period

Not used.

Drug interaction

Sildenafil may increase the effectiveness of hypotension of organic nitrates or organic nitrite, and control Sildenafil in those who are taking these drugs.

Sildenafil may also increase Nicorandil's hypotension and should avoid using these two drugs.

Symptomic hypotension may occur when using Sildenafil with Alpha blockers.

Cytochrom P450 3A4 enzyme inhibitors such as cimetidin, delavirdin, erythromycin, otraconazole, ketoconazole, and HIV-protease inhibitors can reduce Sildenafil's clearance.

Sildenafil's plasma concentration increased significantly by ritonavit.

Grapefruit juice can increase sildenafil levels in plasma.

Cytochrom P450 3A4 enzyme induction, like Rifampicin, is capable of reducing Sildenafil's plasma concentrations.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

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