Decolgen ND United medicine treats common symptoms, allergic rhinitis (12 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 12 blisters x 10 tablets
Ingredient Paracetamol, phenylephrine

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	500mg
Phenylephrine	10mg

Uses

Indications

decocolen nd is indicated to treat common symptoms, allergic rhinitis, vascular rhinitis, influenza mucous membrane, sinusitis and upper respiratory disorders.

Pharmacokology

Paracetamol is a nonsteroidal antipyretic analgesic.

Paracetamol (acetaminophen or N - acetyl - P - Aminophenol) is a substance that metabolism has the activity of phenacetin, an effective antipyretic analgesic that can replace aspirin, however, unlike aspirin, paracetamol is not effective for inflammatory treatment. With equal dose in grams, paracetamol has analgesic and antipyretic effects similar to Aspirin.

Paracetamol with a low dosage that affects the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on body cycloxygenase, only affect cycloxygenase/prostaglandin of central nervous system. Paracetamol does not work on platelets or bleeding time. Paracetamol does not work on platelets or bleeding time.

pharmacokinetic

absorption

Paracetamol is quickly absorbed and almost completely through the digestive tract. Foods can cause long -lasting release pellets to be partially absorbed and carbohydrate -rich foods reduces the absorption rate of paracetamol. The peak concentration of plasma is within 30 to 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is quickly and evenly distributed in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism

Paracetamol metabolizes in Cytocrom P450 in the liver N - Acetyl Benzoquinonimin is an intermediate substance, this substance continues to be associated with the glutathion sulfydryl group to create non -active substances.

Elimination

Mainly metabolic excretion pills are metabolized, the clearance is 19.3L/hour. Selling time is about 2.5 hours.

When using high -dose paracetamol (> 10 g/day), there will be many N - Acetyl BenzoquinoneMin, which depletes the liver glutathion, then N - Acetyl Benzoquinonimin will react with the sulfydrid group of the liver protein that causes liver damage, liver necrosis, which can be deadly if not emergency in time.

Before taking Decolgen ND United medicine treats common symptoms, allergic rhinitis (12 blisters x 10 tablets)

How to use

Take 3 or 4 times a day, after eating.

Dosage

Adults: 1 - 2 capsules/time.

Children:

Children from 2 - 6 years old: 1/2 tablets/time.

Children from 7 - 12 years old: 1/2 - 1 capsule/time. Or according to the instructions of the physician.

Not recommended for children under 2 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The liver necrosis depends on the most serious acute toxic effect due to overdose and may cause death. Nausea, vomiting, abdominal pain usually occur within 2-3 hours and significant symptoms of liver damage within 2-4 days after taking the poisonous dose of the drug. Treatment includes stomach lavage; Acetylcystein is the most effective antidote if started within 10 - 12 hours after overdose; However, Acetylcystein still works if treated within 24 hours.

Overdose of phenylephrine increases blood pressure, headache, convulsions, brain hemorrhage, chest drums, extra mind, restlessness. Slow heart rate usually occurs early. When an overdose occurs, the method of causing vomiting and/or stomach lavage should be taken as soon as possible. In case of significant hypertension can use α - adrenergic blockers like phentolamine.

What to do when forgetting a dose? If the doctor appoints you to use acetaminophen regularly but you forget the dose, take the dose as soon as you remember. However, when you forgot the dose that is almost time for the next dose you can skip the forgotten dose and continue the schedule of your use of decolgen medication. Do not use double dose to compensate for missing dose.

Side Effects

paracetamol (acetaminophen):

Uncommon: skin rash, hematuria, anemia, kidney disease.

Rare: Hypersensitivity reaction.

Phenylephrine can cause restlessness, anxiety, stress, weakness, dizziness, chest pain, tremor, respiratory failure, cyanosis, hair -building reaction.

Please notify your doctor the unwanted effects when using the drug decocolen nd.

Warnings

Before using the drug, you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications Using Decolgen ND in the following cases:

Sensitive to the ingredients of the drug. Alcoholism. Hepatic failure or severe kidneys. Hepatitis progressed by viruses.

Precautions when using

paracetamol (acetaminophen)

Be careful when using paracetamol (acetaminophen) in the following cases: Urinary phenylceton disease, patients who are taking antifreeze drugs, patients who are taking alcohol for a long time, severe kidney failure.

Paracetamol (acetaminophen) is relatively non -toxic to the dose of treatment. Sometimes there are skin reactions including rash, itchy and urticaria. Other sensitive reactions include larynx edema, angioedema, and anaphylactic reactions that may rarely occur.

Ophthalmology, leukopenia, and all bloody hemorrhage occurred with the use of p - aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Be cautious with people with impaired liver or kidney function.

Paracetamol (Acetaminophen) is associated with the risk of serious skin reactions rare. The doctor should warn the patient about signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, and acute overseas pustules syndrome (AGEP). When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug.

phenylephrine

Patients should stop the drug containing phenylephrine and need advice to the doctor if the symptoms last more than 7 days; Or there are symptoms such as high fever, symptoms of restlessness, dizziness, insomnia. Patients should not use drugs containing phenylephrine while being treated or just terminated (for 2 weeks) with Mao inhibitors.

The ability to drive and operate machinery

does not cause drowsiness.

Pregnancy or nursing mothers

Pregnancy

Using phenylephrine for patients at the end of pregnancy or labor can cause deficiency of oxygen and slow the heart rate for the fetus due to increased uterine muscle contraction and reducing uterine perfusion.

Breastfeeding period

Phenylephrine does not appear in breast milk, but should be careful when used for nursing women.

Medicinal interaction

Long -term oral high doses of Paracetamol (Acetaminophen) increases slightly anticoagulant effects of anticoagulants (such as Coumarin, Indandion derivatives).

Out of too much and long -term alcohol can increase the risk of toxicity on the liver of paracetamol (acetaminophen).

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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