Denesity 200mg CPC1 Hanoi Treatment of sensory disorders (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Alpha Lipoic acid
Ingredient CPC1 Pharmaceutical Joint Stock Company Hanoi - Vietnam

Ingredient

Composition information	Content
Alpha Lipoic acid	200mg

Uses

Indications

Denesity drugs treat sensory disorders caused by diabetic polygonitis.

Pharmacokology

Alpha Lipoic acid (Thioctic acid) is a strong antioxidant coenzyme, showing impact in both water and oil environment.

After attacking free radicals, alpha lipoic acid (thioctic acid) is capable of returning to the active self. Alpha Lipoic acid (thioctic acid) also helps restore the activity of some other antioxidants such as vitamin E, vitamin C, glutathion, coenzyme Q10.

Alpha Lipoic acid (Thioctic acid) also plays an important role in glutathion biosynthesis.

After being absorbed, alpha lipoic acid (thioctic acid) converts into dihydripoic acid, this substance helps convert cystin into cysteine and stimulate glutathion biosynthesis.

In a controlled random study, the combination of lipoic acid and omega-3 acid has shown the effectiveness in slowing down the process of cognitive decline and functional activity related to Alzheimer's disease.

On Vivo, lipoic acid has an increased production effect of acetycholin and against the accumulation of peroxy lipid products. It also protects nerve cells through cellular transmission mechanisms including extracellular signals related to the Kinase path.

Research shows that lipoic acid significantly reduces neurodimumation with improvement of observations of nerve cells and rehabilitation.

Lipoic acid stimulates the production of Camp through the Prostanoid EP2 and EP4 receptors, inhibits the synthesis of interferon gamma and inhibits the ability to poison cells in NK cells, lipoic acid treatment reduces the symptoms of multiple sclerosis (MS), autoimmune syllable in the animal model.

Initial research on animals also shows that lipoic acid is capable of promoting the wound process.

Lipoic acid increases new collagen biosynthesis in fibroblasts in normal human skin, research shows that lipoic acid tng effectively the expression and deposition of collagen eliminated in fibroblasts.

Lipoic acid also facilitates the expression of the Collagen Prolyl-4-Hydroxylase enzyme.

In addition, lipoic acid enhances collagen synthesis by activating SMAD signals.

In an in Vivo study, Tigid Lipoic is the inhibitor of Chrysen's beneficiaries (a cigarette smoke element) on Müller cells (Miom1). Research shows that lipoic acid has the effect of reducing or preventing müller cell comfort in retinal degeneration diseases.

On Vivo, lipoic acid shows the effectiveness of preventing and improving the function after mutations, stroke, artery fibrosis.

Dynamic pharmacokinetics

Alpha Lipoic acid (thioctic acid) is easily absorbed by oral, allocated into the liver and converted into dihydro lipoic acid in body tissue. Absolute bioavailability of alpha lipoic acid (thioctic acid) (compared to the injection) is approximately 20%. Alpha acid lipoic acid thioctic) through the blood barrier.

Maximum drug concentration in plasma is achieved after about 30 minutes.

Metabolism occurs mainly due to short oxidation of b-oxidation or S-Methylation chains.

The waste time of the drug in plasma is about 25 minutes. The drug excreted mainly through the kidneys, which is mainly in the form of metabolic (80-90%). Only a small amount of pure excreted drugs through urine.

There is no information on the pharmacokinetics of the drug in patients with liver failure and patients with renal impairment. No need to adjust the dose of the drug in these objects.

Before taking Denesity 200mg CPC1 Hanoi Treatment of sensory disorders (2 blisters x 15 tablets)

How to use

Denesity tablets soft tablets for oral.

Dosage

Dosage recommended: Take 3 capsules a day only 30 minutes before breakfast.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: Causing vomiting or using activated carbon to eliminate the amount of drugs that have not been absorbed from the digestive tract.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects (ADR) when using Denesity you may encounter:

Very popular:> 1/10, Normal:> 1/100 and 1/1000 and 100, rare:> 1/10000 and

Gastrointestinal disorders:

Very rarely gastrointestinal disorders such as nausea, vomiting, stomach pain, diarrhea,

Hypersensitivity reaction:

Very rarely occur skin allergies, urticaria and itching.

Disorders of the nervous system:

Very rarely changes or taste dysfunction.

blood glucose concentration.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Denesity drugs in the following cases:

Hypersensitivity to Alpha Lipoic acid (Incid Thioctic) or any ingredient of the drug.

Be cautious when used

Alpha Lipoic acid (thioctic acid) has unwanted effects, though very rare, is to reduce blood sugar.

Should check blood sugar and adjust the dose of medications for proper diabetes in case of necessity.

The product contains sorbitol, if the patient has a diseases without tolerance with some normal, careful types and should consult a doctor before use.

Products containing sodium methyle-raben, sodium propylparaben can cause some allergic phan.

It is necessary to consult a doctor in case of a history of allergies to their parabens and salt.

Products containing soybean oil. Contraindicated for patients with a history of allergies to soy or peanuts.

Women during pregnancy and lactation

do not recommend the use of alpha lipoic acid (thioctic acid) for pregnant women and nursing women because there are still no full studies on the safety of the drug when used for these subjects.

affects the ability to drive and operate machinery

Due to some unwanted effects such as dizziness, sweating, headache and visual disorders, be careful when using drugs for driving patients and operating machinery.

Interactive drug

The reduction effect when used with cisplatin.

Causes hypoglycemia when used with insulin or other hypoglycemic drugs.

Limitations are used with drugs containing hard -soluble compounds of iron, magnesium and calcium.

Take the drug with Valproic acid and/ or sodium valproat that reduces bioavailability.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.