Depo Medrol 40mg Pfizer injection anti -inflammatory and treat blood disorders, cancer (1 vial x 1ml)

Dosage form Box x 1ml
Specifications Methylprednisolone acetate
Ingredient Pfizer

Ingredient

Composition information	Content
Methylprednisolone acetate	40mg/ml

Uses

Indications

Depo Medrol 40mg drug is indicated in the following cases:

intramuscularly

anti -inflammatory treatment

rheumatism

Supplementary treatment (pain relief, motor therapy, physiotherapy ...) and short -term complementary treatment (to help patients control acute phase or play) in:

Psoriasis arthritis.

Againurgic spondylitis.

For the indications below, if possible, it is advisable to give priority to the spot:

osteoarthritis after injury.

Inflammation of the epidemic in osteoarthritis.

rheumatoid arthritis including rheumatoid arthritis in teenagers (some selective cases can be used in low doses).

Acute and acute epidemic inflammation.

Bone convex inflammation.

Non -specific acute tendonitis.

acute arthritis caused by gout.

Glue system disease

During the play or maintenance treatment in selective cases such as:

Lupus erythematosus.

Systemic dermatitis (muscular inflammation).

Low acute heart inflammation.

Skin disease

Pemphigus disease (autoimmune puffiness on skin and mucosa).

Severe diverse bodies (Stevens-Johnson syndrome).

Peeling dermatitis.

mushroom warts.

Herpes puffiness dermatitis (the top choice is sulfon and treatment with glucocorticoid -acting glucocorticoids to complement).

Allergic condition

Used to control severe or difficult allergic condition when it has failed with conventional treatments such as:

Bronchial asthma.

contact dermatitis.

Allergic dermatitis.

Serum disease.

Seasonal or year -round allergic rhinitis.

Hypersensitivity reactions to the drug.

Reaction of urticaria when transmitting.

Infectious laryngeal edema (the top choice is epinephrin).

Eye diseases

Serious processes of inflammation and allergic and acute allergies such as:

The corneal infection caused by herpes zoster in the eye.

irocytitis, iris inflammation - eyelashes.

Vascular inflammation - retina.

Rear diffuse vascular inflammation.

optic neuritis.

Gastrointestinal disease

To help patients overcome the crisis of the disease in:

Crohn's disease (body treatment).

The situation

To help the ureter or reduce proteinuria in nephrotic syndrome without hematoma of a spontaneous type or erythematoma.

Respiratory disease

Symptomatic sarcoid disease.

Berylii poisoning.

In spreading pulmonary tuberculosis or acute outbreaks when used simultaneously with appropriate tuberculosis chemotherapy.

Leeffler syndrome cannot be controlled by other methods.

Inhalation pneumonia.

Treatment of blood and cancer disorders

Blood disorders

Hematopoeia anemia (autoimmune).

Secondary platelets in adults.

Demonstration of red blood cells (red blood cell anemia).

congenital anemia (Red blood cell line).

Cancers

For treatment to decrease slightly in:

leukemia and lymphoma.

Acute leukemia in children.

Treatment of endocrine disorders

primary or secondary adrenal impairment.

Acute adrenal impairment (hydrocortison or cortison is a selected drug).

Synthetic homogeneous substances can be used with mineralcorticoids when necessary, for babies, the addition of mineralcorticoid plays an important role.

In congenital adrenal glands.

Hypercalcemia is related to cancer.

Pus -free thyroiditis.

Other indications

Meningococcal tuberculosis has clogged subarachia cavity or threatening to simultaneously use appropriate tuberculosis chemotherapy.

Nervous system: Acute phase of multiple sclerosis.

Injected into the epidemic, around the joints, into bags or soft tissue

Supplemented treatment when taking a short time (to help patients control acute phase or drama), in

rheumatoid arthritis.

Acute and acute epidemic inflammation.

acute arthritis caused by gout.

Bone convex inflammation.

Non -specific acute tendonitis.

osteoarthritis after injury.

Injected into wounds

Treatment of keloid scars, hypertrophic, dark, inflammatory localities of

Flat lichen diseases, psoriasis arrays.

granules.

Chronic single lichen (neuritis).

Lupus erythematosus.

Hair loss.

can also use Depo Medrol in cysts or tendons.

Pharmacokology

Methylprednisolon is a strong anti -inflammatory steroid. It has a larger anti -inflammatory effect than Prednisolon and is less tended to keep salt and water than Prednisolon.

Glucocorticoid has a strong impact on the immune process and inflammation, this property is related to many treatment indications of methylprednisolon, including allergy treatment. The anti-allergic effect includes the inhibition of many cytokines such as Interleukin, GM-CSF, TNF-α and other factors that promote the movement of leukemia and the formation of allergic and non-allergic reactions.

These anti -inflammatory properties, inhibitors include:

Prevent immune reactions including: reducing the number of lymphocytes and activities.

Preventing and inhibiting inflammatory processes includes: inhibiting production and releasing other cytokin and intermediate inflammatory substances, inhibiting vascular dilatation, mobilizing leukemia to the inflammatory position and other important processes for inflammatory reactions.

Pharmacokinetics

absorption

A internal study of 8 volunteers has identified the pharmacokinetics of the 40 mg doses of DEPO Medrol intramuscular injection. The average peak concentration in each patient is 14.8 ± 8.6 ng/ml, the average peak time of each patient is 7.25 ± 1.04 hours, and the area under the average curve (AUC) is 1354.2 ± 424.1 ng/ml x hours (dated 1 - 2 l).

Distribution

Methylprednisolon is widely distributed into tissues, through the bloody barrier, and excreted through breast milk. The apparent distribution of the drug is about 1.4 l/kg. The ratio of plasma protein bonds of methylprednisolon is about 77%.

Metabolism

In humans, methylprednisolon is metabolized in the liver into non -active metabolites, the main substances are 20α - hydroxymethylprednisolon and 20β - hydroxymethylprednisolon. The metabolism in the liver occurs mainly through CYP3A4.

Like many types of substrates of CYP3A4, methylprednisolon can also be a substrate of P -Glycoprotein transport protein attaching ATP (ATP - Binding Cassette, ABC), affecting the distribution of tissue and interacting with other drugs.

Elimination

Methylprednisolon's average disposal time is from 1.8 to 5.2 hours. The total clearance is approximately 5 - 6 ml/min/kg.

Before taking Depo Medrol 40mg Pfizer injection anti -inflammatory and treat blood disorders, cancer (1 vial x 1ml)

How to use

Medications used by injection should be tested by the naked eye to find out if there is sediment and change color before use. Strictly compliance with sterilized techniques to avoid infection due to treatment. The drug is not suitable for intravenous or internal injection and is not used as multiple -doses. After using the necessary dosage, remove the leftovers.

Instruction manual:

shake carefully to get a homogeneous mixture.

open the lid above. At this time, the syringe is ready to use. Do not reuse used pumps.

Injecting dose will vary depending on the disease being treated. When you want to have a prolonged effect, you can calculate the weekly dose by multiplying daily dose with 7 and intramuscularly 1 time.

It is possible to determine the dose for each individual depending on the severity of the disease and the patient's response.

For young children and children, the dose is needed, but the dosage will be dominated by the severity of the disease rather than the strict compliance with age and weight.

Hormone therapy is only auxiliary, not a replacement for regular therapy. Need to reduce the dose or stop slowly from the time of taking the drug for a few days. The severity, prognosis and extent of the disease and the patient's reaction to therapy are the main factors in determining the dose. If a spontaneous remission occurs in a chronic disease, it is advisable to stop treatment.

Referred tests in the laboratory, such as urine test, glucose - blood after meals 2 hours, identify blood pressure and weight, chest X -rays should be performed regularly in prolonged therapy. X-ray of the gastrointestinal tract is the need to do in patients with a history of ulcer or indigestion.

For patients with adrenal -genital gland syndrome, it is necessary to intramuscularly, maybe every 2 weeks is appropriate. For maintenance treatment for patients with rheumatoid arthritis, week intramuscular dose will vary from 40 to 120 mg. The common dosage for patients with skin damage is used for general corticosteroid therapy of 40 to 120 mg of methylprednisolon acetate week intramuscularly, lasting 1-4 weeks.

In severe acute dermatitis due to ivy toxic, the disease can support within 8 - 12 hours after an intramuscular injection of a dose of 80 - 120 mg. In chronic contact dermatitis, may need to be repeated at a distance of 5 - 10 days. In dermatitis increased sebum secretion, weeks of 80 mg may be sufficient to control the disease.

After intramuscularly 80 - 120 mg for asthma patients, the disease can support within 6 - 48 hours and this effect lasts for days to 2 weeks. Similarly, in patients with allergic rhinitis (colds), an intramuscular dose of 80 - 120 mg can mitigate the nose symptoms within 6 hours and this effect will last for several days to 3 weeks.

If signs of stress are in the time being treated, the dose increases. If it is necessary to have the highest intensity hormonal effect, it is possible to indicate intravenous methylprednisolon sodium sucinat with high solubility.

Take medication on the spot to have a local effect

When using treatment with Depo Medrol, it is still necessary to coordinate with other common therapies. Although this treatment will improve symptoms, it is not a cure for the disease and this hormone does not work on the cause of inflammation.

rheumatoid arthritis and osteoarthritis

Dosage for injection in joints depends on the size of the joint and the severity of the disease in each patient. In chronic cases, the injection can be reminded from 1 to 5 weeks or more, depending on the degree of remission of the disease achieved from the first injection.

The doses used in the table below are general instructions:

joint size example Scope of dose

Role

20 - 80 mg
wrist
10 - 40 mg
sternum - blow
The same shoulder - blow
4 - 10 mg
Should review the anatomical of the joints related before the injection in the joint.
To achieve adequate anti -inflammatory effects, it is important to be injected into the fluid compartment. Used with the same sterile technique such as poking the waist tube, a sterile needle of 20 - 24 gauge (on a dry syringe) is quickly brought into the epidemic compartment.
Injecting anesthesia with process is a choice. Test a few drops of joint fluid to check the needle into the joint. The injection site for each joint is determined by the location where the epidemic compartment is the most shallow and no large blood vessels or nerves.
With needles in the right place, remove the suction syringe and replace it with a second syringe containing a desired amount of Depo Medrol. Pull the pump up a bit to suck the epidemic and make sure the needle is still in the epidemic compartment. After the injection, the joint is moved gently several times to help mix the discharge into the hanging fluid. The injection site is tied with a small tape.
The appropriate places for injection in the joints are knee joints, ankles, wrists, elbows, shoulders, knuckles and groin. Because the needle into the hip is relatively difficult, it is necessary to be careful to avoid touching every large blood vessel nearby. The joints are not suitable for injections are unable to reach the surgery, such as spinal joints and joints such as the same joints - pelvis without containing the epidemic compartment. The failure of treatment is mostly a result of failure to bring the needle into the joint cavity.
There will be few or not effective if the surrounding tissue is injected. If it fails when the injections are determined to be in the epidemic compartment, determined by sucking joint fluid, then repeated injections often do not benefit. Local medication therapy does not change the basic process of the disease and anytime can be used, so it is recommended to use comprehensive therapy, including physical therapy and orthopedic.
After conducting corticosteroid injection therapy, be careful to avoid excessive exercise for joints that have achieved symptomatic treatment effects. The carelessness in this issue can increase joint destruction and lose the meaning of steroid treatment.
Do not inject unstable joints. In some cases, injecting in the joints may lead to unstable joints. Should take X -ray after injection to detect joint lesions.
If local anesthesia is conducted before the methylprednisolon acetate injection, you should read the anesthetic manual and follow all the alerts.
Bag inflammation
Prepare the area around the injection site on the principle of aseptic and create an burns in the injection site with 1%process hydrochlorid process. A needle of 20 - 24 gauge fitted into a dry syringe is inserted into the bag and the fluid is sucked out. Keep the needle on the spot and replace the suction syringe with a small syringe containing the desired dose. After injection, draw needles and tape with a small tape.
Other diseases: lymphadenopathy, tendonitis, bone convex inflammation
To treat diseases such as tendonitis or tendonitis, be careful, it is necessary to perform appropriate antiseptic on the skin surface before the injection is hung into the tendon instead of entering the substance of the tendon. It is easy to touch the ligaments when stretched out. When treating diseases such as bone -bone convex inflammation, it is necessary to carefully outline the area with the greatest pain sensitivity, then the suspension epidemic is infected into this area. For lymph nodes and tendons, it is necessary to be suspended directly into the follicle. In many cases, an injection causes significantly reduced size of the cyst, sometimes it can disappear tumor.
Dosage treatment of various symptoms of tendon structures or bags listed above will change with treated diseases; The dose changes from 4 mg to 30 mg. In recurrent or chronic diseases, it may be necessary to apply repeated injections.
Need to follow sterile careful measures often used for each injection.
Injecting dose for local effects in skin diseases
After cleaning with an appropriate antiseptic such as 70%alcohol, 20 - 60 mg injected into the lesion site. It may be necessary to divide into doses from 20 mg to 40 mg with repeated local injections in case of large lesions. Be careful to avoid injecting the amount of medicine that causes pale skin, as this can lead to small peeling.
Often use 1 to 4 injections, the distance between injections varies depending on the type of injury being treated and the time needed to improve symptoms after the first injection.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do
do when overdose?
Report on acute toxicity and/or death after corticosteroid overdose is very rare. In case of overdose, no specific antidote but only treatment support and symptomatic treatment.
methylprednisolon can be separated.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Depo Medrol, you may experience unwanted effects (ADR).

Unknown frequency

● Infection and parasitic infection: opportunistic bacterial infections, bacterial infections, peritoneal injections, infections at the injection site.

● Blood and lymphatic system: leukemia.

● The immune system: hypersensitivity reactions to drugs, anaphylactic reaction, anaphylactic reaction.

● Endocrine: Cushing syndrome, impaired pituitary function, steroid cessation syndrome.

● Metabolism and nutrition: Metabolic acidosis, sodium retention, water retention, metabolic alkaline reduction due to hypokalemia, blood lipid disorders, Glucose tolerance, increased demand for insulin (or oral hypoglycemic drugs in diabetes), fat accumulation, increased cravings (can lead to weight gain).

● Mental: emotional disorders (including depression, excitement, unstable emotions, drug dependence, suicide intentions), behavioral disorders (including manic, systemic paranoia, hallucinations, schizophrenia), mental disorders, personality changes, confusion state, anxiety, erratic mentality, irritability, irritability.

● Neurology: epidural fat, increased intracranial pressure (with thorny gai [hyperplation of benign intracranial pressure]), convulsions, memory loss, cognitive disorders, dizziness, headache.

● Eye: dark retinopathy, blindness, cataracts, glaucoma, protruding eyes.

● Ear and inner ear: dizziness.

● Heart: congestive heart failure (in sensitive patients).

● Blood vessels: thrombosis, hypertension, hypotension.

● Respiratory, chest and mediastinum: pulmonary embolism, hiccups.

● Gastrointestinal: Gastrointestinal ulcers (can be perforated due to gastrointestinal ulcers and hemorrhage due to gastrointestinal ulcers), perforation, stomach bleeding, pancreatitis, esophagitis causing ulcer, esophagitis, abdominal distention, abdominal pain, diarrhea, indigestion, nausea.

● Skin and subcutaneous tissue: angioedema, hemorrhoids, hemorrhagic spots, bruises, skin atrophy, erythema, increased sweating, striped skin, rash, itching, urticaria, acne, hyperpigmentation, loss of skin pigmentation.

● Bone muscles and connective tissue: muscle weakness, muscle pain, muscle disease, muscle atrophy, osteoporosis, bone necrosis, fracture due to pathology, neurological joint disease, joint pain, growth of growth.

● Reproduction and mammary gland: irregular menstruation.

● Common disorders and injecting status: Aseptic abscess, difficulty healing wounds, peripheral edema, fatigue, irritating, response at the injection site.

● Testing: glaucoma, decreased carbohydrate tolerance, reducing blood potassium, hypercalcemia in urine, increased alanine aminotransferase enzyme, increased aspartat aminotransferase enzyme, hyperplasia alkaline alkaline, hyper urea, reducing skin reactions during skin tests.

● Trauma, poisoning and complications due to procedures: spinal fractures due to pinched, tendon broken.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Depo Medrol Drugs Contraindicated in the following cases:

● Patients with systemic fungal infections.

● Hypersensitivity to methylprednisolon or any component in the formula.

● Used by internal injection.

● Used by epidural injection.

● Used by intravenously.

● Contraindications for live vaccines or live-reducing vaccines in patients who are taking immunosuppressive corticosteroids.

Be cautious when using

Inject corticosteroids into the condoms can cause systemic and local reactions.

It is necessary to check carefully when the fluid occurs in any joint to eliminate the bacterial process.

The level of pain is significantly increased with local swelling, limiting joint movement, fever and discomfort are signs of suggesting arthritis due to infection. If this complication occurs and the diagnosis of infection is confirmed, it is necessary to conduct appropriate antibiotic treatment.

Need to avoid local steroid injections to the previous infection.

Do not inject corticosteroids into unstable joints.

Need to perform aseptic technique to prevent infection or contamination.

Intramuscular absorption speed will be slower.

Immune -inhibiting effect/Increasing risk of infection

corticosteroids may increase the risk of infection, cover some signs of infection and some new infections may occur while using corticosteroids.

Effects on the immune system

may occur allergic reactions. Because some rare cases of skin allergies and anaphylaxis have occurred in patients with corticosteroids, appropriate preventive measures should be taken before using corticosteroids, especially when patients have a history of allergies to any drug.

Effects on metabolism and nutrition

Corticosteroids, including methylprednisolon, can increase blood sugar, worse the existing diabetes, and can lead to diabetes on prolonged corticosteroids.

Mental effect

Mental disturbances can appear when using corticosteroids, from refreshment, insomnia, mood change, erratic temperament and severe depression to real mental manifestations. In addition, emotional instability or mental trend may be worse by corticosteroids.

Effects on skeletal system

Although controlled clinical trials have shown that corticosteroids have the effect of rapidly reducing acute severity during the exacerbation of multiple sclerosis, those tests do not prove that corticosteroids affect the final treatment results or natural developments of the disease. Studies show that the relatively high corticosteroid dose is needed. There have been reports on epidural fat accumulation in patients with corticosteroids, typically when using high doses.

Effects on the eyes

The prolonged corticosteroid uses can cause cataracts under the posterity and cataract 2 in the center (especially in children), convex or increased intraocular pressure, which can lead to glaucoma accompanied by visual damage. The risk of fungal and secondary viruses may be increased in the eye in patients using glucocorticoids.

Effects on the heart

The undesirable effect of glucocorticoids on the cardiovascular system such as blood lipid disorders and hypertension, can cause patients to have cardiovascular risks to suffer from other cardiovascular effects if high doses and prolonged doses.

Effects on the circuit

thrombosis, including venous thrombosis, has been reported when using corticosteroids. Therefore, corticosteroids need to be used cautiously in patients who are or may be at risk of thrombosis.

Effects on the gastrointestinal tract

Corticosteroid high doses can cause acute pancreatitis.

Effects on the liver

Hepatoma has been reported may recur after treatment. Therefore the appropriate monitoring is necessary.

Effects on skeletal system

There has been a report on acute muscle disease when using high doses of corticosteroids, which often occurs in patients with neurotrotomic disorders (for example, severe muscle weakness), or on patients taking anti -chiolinergic drugs such as neurotransmitter (such as pancuronium). This acute muscle disease spreads, may be related to eye muscles, respiratory muscles and can lead to paralysis. The increase in creatinine kinase may occur. In order to have clinical or recovery progress, it is necessary to stop the drug within a few weeks to a few years.

Osteoporosis is unwanted effect but is less detected when using high and prolonged glucocorticoids.

Kidney and urinary disorders

Should be cautious when taking corticosteroids in patients with renal failure.

Research: The average or high dose of hydrocortison or cortison may cause hypertension, salt and water to keep potassium elimination. These effects are less common with synthetic derivatives unless high doses. The diet that limits salt and potassium supplements may be necessary. All corticosteroids increase calcium excretion.

Trauma, poisoning and complications due to surgery

corticosteroids are not indicated and therefore should not be used to treat brain injury.

Other warnings

Due to complications when using glucocorticoid depends on the dosage and treatment time, it is necessary to consider the benefits/risks on each patient about the dosage and daily treatment time or the use of Japan.

Be careful when using aspirin and nonsteroidal anti -inflammatory drugs in combination with corticosteroids.

Chrome -preferred cell tumor can be reported after using systemic corticosteroids. For patients suspected or have identified as chrome cell tumors, only corticosteroids should only be used after evaluating the appropriate benefits/risks.

This preparation contains sodium. Sodium concentration is less than 1 mmol/1 ml of the injection mixture, so it can be considered as "no sodium"

used in children

Need to closely monitor the growth and development of newborns and children when using prolonged corticosteroids. Growing slow growth can be seen in children using prolonged, daily glucocorticoids, with a dosage and the use of this therapy should be limited, should only be used with the most urgent indications.

Babies and children using long corticosteroids have a special risk of increased intracranial pressure.

Corticosteroid high doses can cause pancreatitis in children.

The ability to drive and operate machinery

Unwanted effects, such as dizziness, dizziness, visual disorders and fatigue may be encountered after corticosteroid treatment. If affected, patients should stop driving or operating machines.

Pregnancy

Animal studies have shown that corticosteroids impair fertility.

Animal research shows that corticosteroids when taking high doses for the mother can cause fetal deformities. However, corticosteroid does not seem to cause birth defects when used for pregnant women. Due to the satisfactory reproductive studies in humans that have not been conducted with methylprednisolone acetate, this pharmaceutical should only be used during pregnancy after careful assessment between benefits and risks for mothers and fetuses.

A few corticosteroids through the placenta fence. A rescue study shows that an increase in the proportion of infant infants born from mothers using corticosteroids. In humans, the risk of giving birth to a light weight seems to be related to the dose and can be minimized by using low corticosteroids.

Babies of mothers who have used corticosteroid dose significantly during pregnancy must be carefully monitored and evaluated about signs of adrenal functional impairment, although rare cases of adrenal insufficiency in infants are exposed to corticosteroids in the uterus.

cataracts have been observed in the newborns that mothers use corticosteroids during pregnancy.

Unknown effects of corticosteroids on labor and childbirth.

Breastfeeding period

corticosteroids are excreted through breast milk.

corticosteroids excreted through breast milk can inhibit growth and affect endogenous glucocorticoid production in infant. This pharmaceutical should only be used during breastfeeding after careful evaluation between benefits and risks for mothers and babies.

Drug interaction

methylprednisolon is the substrate of the enzyme cytochrom P450 (CYP) and is mainly metabolized by CYP3A4 enzyme. CYP3A4 is the main enzyme of most cyp sub -feces in the liver of adults. It catalyzes the process of 6β - hydroxylation steroids, phase 1 essential in the metabolism for both endogenous and synthetic corticosteroids.

There are also many other substances that are also the substrate of CYP3A4, some of these (as well as other drugs) that change the metabolism of glucocorticoid by causing induction (increased air conditioner) or inhibiting CYP3A4 enzyme.

CYP3A4 inhibitors

Including: Isoniazid, Aprilitant, Fosaprepitant, Diltiazem, Ethinylestradiol, Norethindron, Grapefruit juice, HIV - Protease inhibitors, Cyclosporin, Clarithromycin, erythromycin, troleandomycin.

CYP3A4 activated inhibitors generally reduce the liver clearance and increase the concentration of the drugs that are the substrate of CYP3A4 such as methylprednisolon in plasma. If there are CYP3A4 inhibitors, methylprednisolon should be prepared to avoid steroid poisoning.

CYP3A4 induction substances

includes: carbamazepin, phenobarbital, phenytoin.

CYP3A4 induction drugs generally increase the clearance of the liver, leading to reducing the concentration of the drugs as the substrate of CYP3A4. Methylprednisolon may be increased when used with these drugs to achieve the desired treatment results.

substances that are substrate of CYP3A4

Includes: Carbamazepin, Aprilitant, Fosaprepitant, HIV - Protease inhibitors, Diltiazem, Ethinylestradiol, Norethindron, Cyclosporin, Clarithromycin, Erythromycin, Cyclophosphamid, Tacrolimus.

When there is another substrate of CYP3A4, the liver clearance process of methylprednisolon may be affected, so the corresponding adjustment of the dose of methylprednisolon. It is possible that unwanted effects when used each drug will be more likely to occur when used simultaneously.

anticoagulant (oral form)

The effect of methylprednisolon on oral anticoagulants may vary depending on the case. There have been many reports on increasing as well as reducing the effects of anticoagulants when used with corticosteroids. Therefore, it is necessary to check the coagulation indicators to maintain the desired anticoagulant effect.

anti -cholinergic drug - Neuropathy

Corticosteroids can affect the effects of anti -cholinergic drugs.

antiviral drugs

Steroids can reduce the effects of anti -cholinesterase drugs used in the treatment of myasthenia gravis.

Diabetes treatment

Because corticosteroids may increase blood glucose levels, the dose may be adjusted for diabetes.

AROMATASE inhibitors (aminoglutethimid)

Causes the adrenal gland inhibitors, can worsen the hormonal changes due to prolonged glucocorticoid use.

NSAID (Aspirin) high doses

The ratio of bleeding and gastrointestinal ulcers may increase when using methylprednisolon along with NSAID drugs. Methylprednisolon may increase the clearance of high doses of aspirin, which can lead to reduced serum salicylate concentration. Stop treatment with methylprednisolon can lead to increased serum salicylate levels, which can lead to an increased risk of salicylate poisoning.

Medications increase potassium discharge

When using corticosteroids along with drugs that increase potassium emissions (for example, diuretics), should closely monitor the phenomenon of hypokalemia in patients. The use of corticosteroids with amphotericin B, Xanthin or Beta 2 leftovers also increases the risk of hypokalemia.

Storage

Store at a temperature not exceeding 30 ° C.

Other drugs

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