Deruff 8mg Davipharm Treatment Treatment of mild to moderate intellectual decline (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Galantamin
Ingredient Dat Vi Phu Pharmaceutical Company Limited - Davipharm

Ingredient

Composition information	Content
Galantamin	8mg

Uses

indications

Deruff is indicated in the following cases:

galantamin is used to treat mild to moderate dementia in Alzheimer's disease. Galantamin is inversely attached and active acetylcholininininininisterase, thus inhibiting acetylcholin hydrolysis, increasing acetylcholin levels at Synap Cholinergic. In addition, the drug also increases the activity of acetylcholin on nicotinic receptors.

The deficiency of acetylcholin in the cerebral cortex, fillings and horses is considered one of the premature pathological characteristics of Alzheimer's disease, causing intelligence and perceptions. Anti -cholinesterase such as galantamin increases acetylcholin content, which reduces the development of the disease. The effect of galantamin may decrease as the disease progresses and only few acetylcholine neurons are still active.

pharmacokinetics

galantamin is an alkaline compound with a liveli electric constant pKa = 8.2. Galantamin slightly oil body and distribution coefficient (log p) between n-octanol/buffer solution PH 12 is 1.09. Galantamin's water solubility (pH 6) is 31mg/ml. Galantamin has 3 carbon opposite. Form S, R, S are natural forms.

galantamin is partially metabolized by a lot of cytochrom, mainly CYP2D6 and CYP3A4. Some metabolites formed during the galantamin recession shows in vitro activity but does not have the important activity in vivo.

absorption

Galantamin absorbs fast, with TMAX about 1 hour after drinking. The bioavailability of galantamin 88.5 ± 5.4%. Using drugs with food reduces the absorption rate of the drug and reduces CMAX about 25%, but does not affect the absorption level (AUC).

Distribution

The average distribution volume is 175L. The drug is less associated with plasma proteins, the rate is 18%. Metabolic about 75% of galantamin dose is eliminated in the form of metabolites. In vitro research shows that CYP2D6 plays a role in the formation of O-Desmethylgalantamin and CYP3A4 plays a role in the formation of N-Oxyd-Galantamin. The total level of radioactive isotope is eliminated in feces and urine is not different between people with metabolism through CYP2D6 small and high.

In the plasma of people with metabolism through CYP2D6 small and high, galantamin is in a constant form and its glucuronid form occupies most of the radioactive marks. No metabolites have any activity (Norgalantamin, O-Desmethylgalantamin and O-Desmethyl-Norgalantamin) can be detected in non-conjugate forms in people with a small and small CYP2D6 transformer.

Norgalantamin was discovered in plasma in patients after repeated dose, but did not account for more than 10% of galantamin concentration. In vitro research shows that Galantamin's inhibition ability with the main types of Cytochrom P450 in humans are very low.

Elimination

Galantamin plasma concentration decreases according to level 2 function, with a half -life of 7-8 hours in healthy objects. The clearance of oral use in patients is about 200ml/minute with the difference between the objects is 30%. Seven days after taking a single dose of 4 mg 3H -Galantamin, 90 - 97% of the radioactive dose found in the urine and 2.2 - 6.3% were found in the feces. After intravenous and oral injection, 18-22% of the dose is eliminated in the form of galantamin unchanged in urine for 24 hours, with the clearance of the kidney is 68.4 ± 22.0ml/min, showing 20-25% of the total plasma clearance.

Before taking Deruff 8mg Davipharm Treatment Treatment of mild to moderate intellectual decline (4 blisters x 7 tablets)

How to use

You should use galantamin twice a day in the morning and evening, with water. You should take medicine with food. Drink plenty of water when using the drug to keep the body sufficient water.

Dosage

You will start galantamin at low doses. The starting dose is usually 4mg, used 2 times/day (the total dose is 8mg/day). The doctor will increase the dose slowly for you, every 4 weeks or more, until you achieve the right dose.

The maximum dose is 12mg, use 2 times/day (a total dose of 24mg/day). The doctor will tell you the starting dose and when the dose is needed. If you don't know what the problem, or feel the effect of galantamin is too strong or too weak, notify your doctor or pharmacist. The doctor will need to see you regularly to check the effects of the drug and discuss how you feel.

If you have liver or kidney problems, your doctor may reduce the galantamin dose for you or may decide that this drug is not suitable for you.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? If you overdose or children swallow the drug, contact the nearest doctor and medical center immediately. When overdose, you may vomit and vomit, myasthenia gravis, slow heart rate, seizures (epilepsy) and consciousness.

Stop taking medication and contact immediately with the nearest doctor or medical center. Carrying a pills along with the packaging so that the doctor knows what medicine you have taken and takes timely measures.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using deruff, you may experience unwanted effects (ADR).

Skin reactions include

Heavy rashes with rooms and peeling, especially in the area around the mouth, nose, eyes and genital organs (Stevens-Johson syndrome).

Red rashes covered by pustules can spread throughout the body, sometimes with a fever (acute pustules are acute).

You can bulge, with small spots. These reactions are rare in patients using galantamin (encountered at 1 to 10 of 100,000 users).

Heart problems, including changes in heart rate (such as slow heartbeat, additional beating) or irregular drumming). Heart problems may cause abnormal traces on the electrocardiogram, and may be common in patients with galantamin (encountered at 1 to 10 of the 100 users).

Scratch (epilepsy) is rarely found in patients using galantamin (encountered at 1 to 10 of the user).

Other undesirable effects

Very common (encountered in more than 1 of 10 users):

Nausea and vomiting. These unwanted effects usually occur in the first few weeks of treatment or when increasing the dose. These unwanted effects tend to disappear slowly from the time when the body is familiar with the drug and generally only lasts a few days. If you experience these effects, your doctor may recommend drinking more water and may give the medicine to reduce your symptoms.

Common, ADR> 1/100

Anorexia, weight loss.

See, feel, or hear things that are not real (hallucinations).

Depression, dizziness or fainting.

Run muscles or muscle spasms.

Headache.

Feeling very tired, weak and unwell body. The feeling is very sleepy and lack of energy.

Hypertension.

Abdominal pain or abdominal discomfort.

Diarrhea, indigestion.

falls, injured.

Uncommon, 1/1000

Allergic reaction.

Lack of water in the body.

Feeling numbness or stinging on the skin.

Change the taste.

Sleep during the day.

blurred vision.

tinnitus.

Hypotension.

flushed.

The feeling of wanting to vomit (vomiting).

Increase sweating.

weak muscle.

Increased liver enzyme levels.

Rare (ADR

Hepatitis.

The drug may have other unwanted effects, notify the doctor with unwanted effects when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Deruff drugs contraindicated in the following cases:

Hypersensitivity to galantamin or any ingredients of the drug.

There is liver disease or severe kidney disease.

Precautions when using

Talk to the doctor before taking the medication. Galantamin is only used to treat Alzheimer's disease and is not recommended in other forms of dementia or confusion. Serious unwanted effects Galantamin can cause serious skin reactions, heart problems, seizures (epilepsy). You must pay attention to these unwanted effects when using galantamin.

Before taking this medication, notify your doctor if you are having the following health problems:

Liver or kidney problems.

The condition in the heart (such as uncomfortable chest is often due to physical activity, stroke, heart failure, heart rate slow and irregular).

Change electrolyte levels (substances often in the blood, like potassium).

Stomach ulcer.

gastric or intestinal obstruction.

nervous system disorders (such as epilepsy or Parkinson's disease).

Respiratory or infections affect respiratory (such as bronchial asthma, pulmonary obstruction or pneumonia).

Difficult.

The doctor will decide whether Galantamin is right for you, or if you need to change the dose or not. You also need to notify your doctor if you have recent stomach, intestinal or bladder surgery. The doctor may decide that Galantamin is not suitable for you.

galantamin can cause weight loss, the doctor will check your weight regularly when you use galantamin. Deruff contains polysorbat 80 that can cause allergies and castor oil can cause nausea, vomiting, abdominal pain, diarrhea. Deruff contains erythrosin color, Sunset Yellow, Brilliant Blue color can cause allergies.

The ability to drive and operate machinery

galantamin can make you feel dizzy or drowsiness, especially in the first few weeks of treatment. If you are affected, do not drive or operate machinery.

Pregnancy

If you are pregnant, think you may be pregnant or intend to get pregnant, consult your doctor or pharmacist before taking the medication.

Breastfeeding period

You should not breastfeed while taking Galantamin.

Medicinal interaction

should not use galantamin with similar effects, including: Donepezil or Rivastigmin (treatment of Alzheimer's disease).

Ambenonium, Neostigmin or Pyridostigmin (treatment of severe muscle weakness).

pilocarpin (when used oral to treat dry mouth or dry eyes).

Some drugs may increase the unwanted frequency of galantamin, including:

paroxetin or fluoxetin (antidepressants).

quinidine (irregular heart rate treatment).

erythromycin (antibiotics).

ritonavir (HIV treatment).

Non -steroid anti -inflammatory (NSAID) (such as ibuprofen), these drugs may increase the risk of ulcer.

The drug is used to treat heart condition or hypertension (such as digoxin, amiodaron, atropin, beta blockers, or calcium channel blockers). If you are taking uneven heart rate treatment, your doctor can check your heart with an electrocardiogram. Your doctor may give you a lower doses of galantamin if you are taking the above medications. Galantamin may affect some anesthetic. If you are about to have surgery, you need all over the body, notify the doctor you are taking Galantamin.

Storage

Keep the drug in the original packaging of the manufacturer, covered.

Leave the drug in a dry place, avoid light, the temperature does not exceed 30 ° C, and out of the reach of children.

Do not use the drug after the expiry date indicated on the packaging (box and blister box).

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