Deslora 5mg medication reduces seasonal allergies and allergic rhinitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Desloratadine

Ingredient

Thành phần cho 1 viên

Composition information	Content
Desloratadine	5mg

Uses

Indications

Allergic rhinitis: reduce the symptoms of allergic rhinitis (seasonal and chronic) in patients 12 years old or older: sneezing, nose, itching, stuffy nose, with eye irritation, watery and red eyes.

Chronic spontaneous urticaria: Reducing the symptoms of itching, erythema for patients aged 12 and older suffering from chronic hunting.

Pharmacokological

Desloratadin is a loratadin -active metabolic substance, which has a selective antagonistic effect with the peripheral H1 receptors. The effect of desloratadine due to inhibits the cohesion of histamine in the cycle of the receptor position. The drug does not prevent the release of histamine. Desloratadin inhibits the smooth muscle contraction of the respiratory system, circulatory system, digestive system, reducing the secretion of active histamine from the salivary glands and the thus and therefore anti -inflammatory effects. The drug also reduces capillary permeability, so it reduces itching and allergic inflammation. Because desloratadin does not pass through the bloody barrier and has the effect of selecting the peripheral receptor - histamine, the sedative and sympathetic effect of the desloratadine is low.

pharmacokinetic

absorption

After giving healthy people volunteering to drink 5mg Desloratadin once a day, the maximum concentration in plasma reaches 3 hours after drinking and the maximum concentration in plasma in an average stable state is 4NG/mL, the area under the curve (AUC) is observed as 56.9ng/hour/ml.

Food and grapefruit juice does not affect the bioavailability of desloratadin.

Distribution

Desloratadin and 3 - Hydroxy Desloratadin attached to plasma protein corresponding to about 82 - 87% and 85 - 89%. In patients with renal failure, this ratio does not change.

Metabolism

desloratadin (Loratadin's main metabolites) are strongly metabolized to 3 - hydroxy desloratadin, an active metabolite and then glucuronicization. The enzymes play a role in forming 3 - Hydroxydesloratadine.

Elimination

The average disposal time of desloratadin is 27 hours. The maximum concentration in plasma and AUC increases in proportion to the oral dose of 5 - 20mg. The concentration accumulated after 14 days of treatment depends on the sale time and the dose distance.

A study has found that 87% of 14C - Desloratadin has been exported evenly in urine and feces as metabolic products.

Before taking Deslora 5mg medication reduces seasonal allergies and allergic rhinitis (3 blisters x 10 tablets)

How to use

Because the food does not affect the bioavailability of the drug, the patient can take Desloratadin pills without depending on the meal.

Dosage

Adults and children ≥ 12 years: 1 capsule 1 time/day.

Patients with liver failure, kidney failure: The starting dose is 1 tablet/day, drinking day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Information about acute overdose is limited. In a test with a dose of about 10 - 20mg/day, the phenomenon of sleeping chicken has been reported.

In case of an overdose, the drug must be removed immediately without being absorbed from the body. Need symptomatic treatment and support. In a clinical test when using Desloratadin 45mg many times (9 times the clinical doses) does not see harmful effects. Desloratadin cannot be removed from the body with a hemorrhage.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Safety records

In clinical trials for indications including allergic rhinitis and chronic hunting, with the recommended dose of 5mg daily, the undesirable effect of the desloratadin is reported in more than 3% of patients compared to the placebo -treated group. The most common unwanted effect is reported more than the placebo group is tired (1.2%), dry mouth (0.8%) and headache (0.6%).

Children

In a clinical trial with 578 minor patients 12-17 years old, the most unwanted effects are headaches, occurs in 5.9% of patients treated with desloratadine and 6.9% of placebo patients. Other undesirable effects have been reported during the circulation of drugs in children with unknown frequency including extension, arrhythmia, slow heart rate.

Unwanted effects

The frequency is determined as follows: Very common (ADR ≥ 1/10), common (1/10> ADR ≥ 1/100), less encountered (1/100> ADR ≥ 1/1000), rare (1/1000> ADR ≥ 1/10000), very rare (ADR

Mental disorders

Very rare: illusion.

Nervous system disorders

Common: headache.

Very rare: tachycardia, chest drum.

Common: dry mouth.

Very rare: increased liver enzyme, increased bilirubin, hepatitis.

Unknown: Jaundice.

Unknown: light sensitivity.

Very rare: muscle pain.

General disorder

Common: fatigue.

Warnings

Contraindicated

Patients with hypersensitivity to loratadin, desloratadin or any ingredients of the drug.

Be cautious when taking drugs

Before using Deslora, you should note some of the following:

Notify the doctor and pharmacist if you are allergic to Deslora, any other drug or any ingredients in the drug. You can also ask the pharmacist for a list of ingredients.

Be cautious when used for people with liver failure, severe kidney failure, elderly.

Pregnant and lactating women.

Children under 12 years old.

The ability to drive and operate machinery

Desloratadin can cause some unwanted effects on the central nervous system such as headache, dizziness, drowsiness. Therefore, it is necessary to be cautious when using the drug for patients while driving and operating machinery.

Pregnancy and lactation

Pregnancy

Data on pregnant women (more than 1,000 pregnant women) shows no deformities as well as no toxicity on the fetus/infant when using desloratadin. Animal research does not see direct or indirect harm related to reproductive toxicity. To prevent it, avoid using desloratadin during pregnancy.

Breastfeeding period

Desloratadin has been found in infants raised with breast milk of women being treated with desloratadin. It is unclear the influence of desloratadine on newborns. Therefore, you should decide to stop breastfeeding or stop using desloratadin after considering the benefits of breastfeeding and the benefits of the mother's treatment.

Other special subjects (elderly, children, allergies)

Not for children under 12 years old.

Drug interaction

There is no clinical interaction when using the drug in combination with erythromycin or ketoconazole. However, enzymes that play the role of metabolism of desloratadine have not been determined, so it is not possible to completely eliminate the interactions that may occur with other drugs.

In a clinical trial when the desloratadin is used in combination with alcohol, the result does not increase the effects of alcohol.

In controlled clinical studies, simultaneous use of desloratadine with fluoxetin (Serotonin selective reabsorption inhibitor) or with cimetidine (H2 huistamine resistant), showing an increase in the concentration of desloratadine and 3 - hydroxydesloratadln in plasma, but there is no clinical change in clinical profile in the safety profile of the safety profile of the safety profile Desloratadin.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer.

You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

Expiry date: 36 months from the date of manufacture.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.