Deslornine 5mg Abbott medicine reduces symptoms of sneezing, nose, urticaria (1 blister x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 1 blister x 10 tablets
Ingredient Desloratadin

Ingredient

Composition information	Content
Desloratadin	5mg

Uses

Indications

Deslornine drugs are indicated for treatment for adults and children over 12 years old to:

Reduce the symptoms of allergic rhinitis such as sneezing, nose and itchy nose, as well as itchy eyes, tearing and red eyes, itchy throat.

ATC code: R06AX27

Desloratadin, the main and main metabolites of loratadin, is the antagonist with selective histamine in the peripheral H1 receptor, prolonged effect, does not cause drowsiness.

After drinking, desloratadin selectively inhibits H1 histamine receptors on the periphery, because the drug is completely absorbed into the central nervous system.

Desloratadin has been shown to have anti -allergic effects from in vitro tests. These effects include inhibiting the release of cytokine onset as IL-4; IL-6; IL-8 and IL-13 from alkaline moisturizer/white blood cells, as well as inhibit the exposure of p-selectin-adhesive molecules on endothelial cells.

Dynamic pharmacokinetics

can detect desloratadine concentration in plasma within 30 minutes after taking the drug. Desloratadine is well absorbed, reaching the peak concentration in plasma after about 3 hours; The last waste sale time is about 27 hours. The accumulation of desloratadine is suitable for the sale time (about 27 hours) and a dose once a day. In adults and adolescents, the bioavailability of desloratadin is proportional to the dose of about 5-20 mg.

Desloratadin is moderately linked to plasma proteins (83-87%). There is no evidence of clinical accumulation accumulation after taking a single dose of 5-20 mg daily, in 14 days.

It is not known that enzymes are responsible for metabolic of desloratadin, so it is not possible to completely exclude the interaction with some other drugs. In vivo studies with special inhibitors CYP34A and CYP2D6 show that these enzymes do not play an important role in the metabolism of desloratadin. Desloratadin does not inhibit CYP34A and CYP2D6 and nor is the substrate or inhibitor p-Glycoprotein.

Patients with renal impairment: Desloratadine pharmacokinetics in patients with chronic renal impairment (CRI) were compared to healthy people in a single -dose and multi -dose study. In a single dose study, the contact with desloratadin was 2 and 2.5 times higher in patients with mild to moderate and severe kidney failure in order compared to healthy people. In multi -dose study, stable state achieved after the 11th day and compared to healthy people, the level of contact with desloratadin is 1.5 times higher in patients with mild to medium to medium and 2.5 times chronic renal failure in patients with severe kidney failure. In both studies, changes in contact (AUC and CMAX) by desloratadine and 3-Hydroxydesloratadin are not clinically related.

Before taking Deslornine 5mg Abbott medicine reduces symptoms of sneezing, nose, urticaria (1 blister x 10 tablets)

How to use

Deslornine can take the same or not with food.

Dosage

Adults and children aged 12 and older: 1 tablet/time/day.

Non -continuous allergic rhinitis (symptoms that appear 4 days/week and last> 4 weeks), can be treated continuously during exposure to allergens.

Children: The safety and effectiveness of desloratadin 5mg in children under 12 years old has not been set up. No data on safety and efficiency.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Information on overdose is limited. In a multi -dose clinical trial in adults and adolescents with desloratadine doses up to 45 mg (9 times the normal dose of treatment), does not observe the clinical related effect.

Handling

In case of overdose, consider using standard measures to eliminate the active ingredient that has not been absorbed. Symptomatic and supportive treatment should be taken.

Desloratadin is not eliminated by hemolysis, it is unknown whether it is excreted by peritoneal.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Deslornine drugs often experience unwanted effects (ADR) such as:

The frequency is determined as follows:

Very common: ADR ≥ 1/10.

Common: 1/100 ≤ ADR

Nervous system disorders Common headache Breaking the chest drum flow

liver-dysfunction very rare high liver enzymes, increase bilirubin, hepatitis unknown In the morning, Disorders of musculoskeletal and connective tissue very rare Muscle pain Magnish, shortness of breath, itching, rash and urticaria)

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Deslornine drugs contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Be cautious when used

Use medication carefully in case of severe renal failure.

Need to reduce the dose of desloratadine in patients with liver failure.

Avoid drinking alcohol while taking the drug.

There has been a report on seizures that appear in patients taking antihistamine drugs, so they should be cautious when taking desloratadine for patients with epilepsy history.

Use for children: Desloratadin 5mg is not suitable for children under 12 years old.

The effect of drugs on driving and operating machinery

Desloratadin does not affect or affect the ability to drive and operate machinery based on clinical trials. Patients need to be informed that most people do not get drowsy. However, because there is a separate difference in response to all drugs, patients are advised not to participate in activities that require alertness such as driving or operating machinery, until they determine the body's reaction to the drug.

Use drugs for women during pregnancy and lactation

used for pregnant women

Many data on pregnant women (more than 1,000 results of pregnancy) shows that using desloratadin does not cause deformities and does not cause toxicity in the fetus/infant. Animal studies do not indicate direct or indirect harm to reproductive toxicity. As a preventive measure, avoiding the use of desloratadine during pregnancy.

used for breastfeeding women

Desloratadin is excreted into breast milk. It is unclear the impact of desloratadine on infants and young children. It is necessary to decide whether to stop breastfeeding or stop using desloratadin, consider the benefits of breastfeeding and the benefits of the mother's treatment.

reproduction

There is no data on fertility of men and women.

Drug interaction

There is no interaction of desloratadine in clinical studies.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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