Detiatic drugs treat pain symptoms, intestinal disorders, intestinal discomfort (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Trimebutine
Ingredient Gastric, intestinal spasms, spasms, digestive disorders

Ingredient

Composition information	Content
Trimebutine	100mg

Uses

indications

Detiatic drug 100mg is indicated in the following cases:

Treatment of pain symptoms, intestinal disorders and intestinal discomfort associated with intestinal dysfunction.

Pharmacokology

trimebutin is a medication that changes the movement capacity of the digestive tract.

trimebutin has the intention of fortune on the Enkephalin system. Trimebutin stimulates the intestinal activity by causing the waves of phase III spread by moving complexes and inhibiting motor ability when there is a previous stimulation (in animals).

In vitro, trimebutin works by blocking sodium channels (IC50 = 8.4 µm) and inhibits the release of the chemical intermediate substance of pain (glutamate).

In the mouse, it inhibits the reaction of the colon and rectum of animals in different experimental models.

pharmacokinetics

absorption:

After drinking, trimebutin quickly absorbed from the digestive tract. The maximum drug concentration in plasma is achieved after 1-2 hours. Birth of 4-6%. The drug has the main effect of intestinal absorption.

Distribution:

The concentration of plasma protein bonds is about 5%low. The distribution volume (V) (d) is about 88 millimol/dl. Trimebutin through a small part of the placenta.

Metabolism:

Maximum metabolic drugs in the liver into trimebutin biotransormiretsa.

Era:

Trimebutin appears in urine mainly as metabolites (about 70% of the drug concentration is eliminated after 24 hours). T1/2 about 12 hours.

Before taking Detiatic drugs treat pain symptoms, intestinal disorders, intestinal discomfort (2 blisters x 10 tablets)

How to use

Take oral, before meals.

Dosage

Adults: The common dose is 1 tablet x 3 times/day.

In the exception, the dose may increase up to 6 tablets/ day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

No report on overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using detides, you may experience unwanted side effects (ADR).

Rare, ADR

Digestive: dry mouth, bad breath, diarrhea, indigestion, nausea and constipation.

Neurology: Dreaming tired, dizziness, headache.

Skin type - jute soft tissue.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Detiatic drugs are contraindicated in the following cases: hypersensitivity to trimebutin or any ingredients of the drug.

Be cautious when using

There is no data recorded at this time.

The ability to drive and operate machinery

Using the usual doses, there is no evidence that detides impaired these activities. Caution should be prudent if high doses, because the drug can cause dizziness, dizziness, drowsiness.

Pregnancy

should not be used for pregnant women.

Breastfeeding period

should not be used for nursing women.

Drug interaction

trimebutin can increase the unwanted effects of D-Tubocurarin.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

S.P.M Company is a manufacturer and distributor of pharmaceutical products, with a factory producing drugs and functional foods that meet quality standards and put into operation in Tan Tao Industrial Park, Ho Chi Minh City, Vietnam.

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