Devastin 10 Bidiphar medicine for hypercholesterolemia, mixed blood lipid disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rosuvastatin
Ingredient High blood fat, high blood cholesterol

Ingredient

Composition information	Content
Rosuvastatin	10mg

Uses

Indications

Devastin drugs are indicated in the following cases:

Increased primary cholesterol (IIA type including hyperlested hyperlly heterozygous family) or mixed blood lipid disorders (Lib type): is a supportive therapy for a diet when the patient does not fully meet the diet and other non -drug therapies (such as exercise, weight loss). Diets and other lipid reduction treatments (such as blood enlightenment) or when these therapies are not appropriate. Coenzyme A Thanh Mevalonate, a precursor of cholesterol.

pharmacokinetics

The peak concentration of plasma of rosuvastatin reaches about 5 hours after drinking. Absolute bioavailability of about 20%, widely distributed in the liver is the main place where cholesterol synthesis and LDL clearance - C. The distribution of Rosuvastatin is about 134L. About 90% of rosuvastatin combined with plasma proteins, mainly with albumin. Rosuvastatin is less metabolized (about 10%). About 90% of the dose of rosuvastatin are eliminated in a constant form (including the active ingredient that is absorbed and not absorbed) and the rest is excreted into urine. About 5% are excreted into unchanged urine. Selling time for plasma is about 19 hours. The sale time does not increase when using a higher dosage. The average plasma clearance is about 50 liters/hour.

Before taking Devastin 10 Bidiphar medicine for hypercholesterolemia, mixed blood lipid disorders (3 blisters x 10 tablets)

How to use

Take oral use. Rosuvastatin can be used anytime of the day, during or away from meals.

Dosage

How is Rosuvastatin dose for adults?

The recommended starting dose is Rosuvastatin 10mg, taken once a day and most patients are controlled at this starting dose. If necessary, the dose can be increased to 20mg after 4 weeks. The dose increasing to 40mg should only be used for patients with severe hypercholesterolemia that is at high risk of cardiovascular disease (especially patients with household blood cholesterol) without achieving treatment goals at a dose of 20mg and these patients need to be monitored regularly.

When used simultaneously with Atazanavir, Atazanavir + Ritonavir or Lopinavir + Ritonavir, limit the dose of rosuvastatin up to 10mg/time/day.

What do rosuvastatin dose for children?

Dosage for children has not been reported.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Using more drugs will not improve your symptoms; Instead they can cause poisoning or serious side effects. If you suspect that you or anyone else may have overdosed Devastin, please go to the emergency room at the nearest hospital or hospital. Bring a box, shell, or pharmacy with you to help doctors have the necessary information. Do not give your medicine to others even though you know they have the same disease or look like they may have the same disease. This can lead to overdose.

There is no specific treatment when using an overdose. When an overdose, patients should be treated with symptoms and applied supportive measures when necessary. Should monitor liver function and ck concentration. Blood decomposition may not benefit.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Devastin, you may experience unwanted effects (ADR). Some of the side effects recorded in research on users of this drug are:Common

headache, dizziness, constipation, nausea, abdominal pain, itching, rash and urticaria, muscle pain, weakness.

Rare

Hypersensitivity reactions including angioedema, muscle disease, muscle pattern, tend to depend on the dose.

This is not a full portfolio of all side effects and may occur other side effects. If you encounter any unwanted effect, stop taking the medication and immediately notify your doctor or immediately go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Rosuvastatin drugs are contraindicated in the following cases:

Patients with hypersensitivity to rosuvastatin or any excipients of the drug.

Patients with severe renal impairment (Creatinine clearance

Patients with muscle disease.

Patients who are taking cyclosporin.

Pregnant and lactating women, women may be pregnant without using appropriate contraception.

Be cautious when using the drug

Notify the doctor and pharmacist if you are allergic to Losartan, any other drug or any ingredients in the drug. You can also ask the pharmacist for a list of ingredients.

Need to do liver enzyme test before starting statin treatment and in case of clinical indications require later testing.

History of muscle toxicity due to other HMG - Coa Reductase inhibitors or fibrates.

Conditions can cause increased drug concentration in plasma.

When using high doses, the Creatine Kinase (CK) enzyme is required because the risk of influence on the muscle.

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to the use of statin or fibrat before, a history of liver disease and/or drinking lots of alcohol, elderly patients (> 70 years old) have risk factors for muscle pattern, special patients and some patients. In these cases, the benefits/risks should be considered and monitor patients clinically when treated with statin. If the results of CK test> 5 times the upper limit of normal levels, do not start treatment with statin.

During statin treatment, patients need to notify when there are muscle manifestations such as muscle pain, stiffness, muscle weakness ... When these manifestations, patients need to do CK test to take appropriate interventions.

Simultaneous use of rosuvastatin with HIV and hepatitis C (HCV) can increase the risk of muscle damage, the most seriousness is muscle pattern, kidney damage leading to kidney failure and can be fatal.

The ability to drive and operate machinery

drugs have side effects that cause dizziness, headache so be careful when driving and operating the machine.

Pregnancy and lactation

Pregnancy

Do not use rosuvastatin during pregnancy.

Breastfeeding period

Do not use rosuvastatin during breastfeeding.

Special subjects (elderly, children, allergies)

No report.

Medicinal interaction

What drug can Rosuvastatin interact with?

Medication interactions may change the ability of the drug or increase the effects of side effects. It is best to write a list of drugs you are taking (including prescription, non -prescription and functional foods) and for doctors or pharmacists. Do not arbitrarily take the drug, stop or change the dosage of the drug without the permission of the doctor, especially:

Increased risk of muscle damage when using rosuvastatin simultaneously with: gemfibrozil, other fibrat blood cholesterol medications, high -dose niacin (> 1g/day), Colchicin. France replaces hormones.

Does the food and alcohol interact with rosuvastatin?

Please consult your doctor about taking medicine with food, alcohol and tobacco.

What health condition affects Rosuvastatin?

Your health status may affect the use of this drug. Tell your doctor if you have any health problems.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer.

You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

Expiry date: 24 months from the date of manufacture.

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