Devastin 20 Bidiphar medicine for hypercholesterolemia, mixed blood lipid disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rosuvastatin
Ingredient High blood fat, high blood cholesterol

Ingredient

Composition information	Content
Rosuvastatin	20mg

Uses

Indications

Devastin indicated treatment in the following cases:

Increasing cholesterol (IIA type, including hyperlested hyperlly heterozygous family) or mixed blood lipid disorders (type IIb): is a supportive therapy for diet when the patient does not fully respond to diets and other non -drug therapies (such as exercise, weight loss). Increasing household blood cholesterol type: Use to support diets and other lipid reduction treatments (such as blood ldl excerpts) or when these therapies are not appropriate.

Pharmacokological

Rosuvastatin is a selective and competitive inhibitor on HMG-CoA Reductase, is the catalyst of the 3-hydroxy-3-methylutaryl coenzyme a into Meovalonate, a precursor of cholesterol.

pharmacokinetics

The peak concentration of plasma of rosuvastatin reaches about 5 hours after drinking. Absolute bioavailability is about 20%, widely distributed in the liver is the main place for cholesterol and LDL-C clearance. The distribution of rosuvastatin is about 134 L. About 90% of rosuvastatin combined with plasma proteins, mainly with albumin.

Rosuvastatin is less metabolized (about 10%). About 90% of the dose of rosuvastatin are eliminated in a constant form (including the active ingredient that is absorbed and not absorbed) and the rest is excreted into urine. About 5% are excreted into unchanged urine. Selling time for plasma is about 19 hours. The sale time does not increase when using a higher dosage. The average plasma clearance is about 50 liters/hour.

Before taking Devastin 20 Bidiphar medicine for hypercholesterolemia, mixed blood lipid disorders (3 blisters x 10 tablets)

How to use

Drug tablets for oral film.

Dosage

The recommended starting dose is Rosuvastatin 10 mg, taken once a day and most patients are controlled at this starting dose. If necessary, the dose can be increased to 20 mg after 4 weeks. The increase in the dose to 40 mg should only be used for patients with severe blood cholesterol hyperplation that is at high risk of cardiovascular disease (especially patients with household blood cholesterol) without achieving treatment goals at a dose of 20 mg and these patients need to be monitored regularly.

Rosuvastatin can be used at any time of the day, during or away from meals.

When used simultaneously with Atazanavir, Atazanavir + Ritonavir or Lopinavir + Ritonavir, limit the dose of rosuvastatin up to 10 mg/time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Blood decomposition may not benefit.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Devastin often has unwanted effects (ADR) such as:

Common: headache, dizziness, constipation, nausea, abdominal pain, itching, rash and urticaria, muscle aches, weakness.

Rare: Hypersensitivity reactions including angioedema, muscle disease, muscle pattern, tend to depend on the dose.

There are also some other unwanted effects such as: perception decline (dementia, confusion ...), hyperglycemia, HBA1C.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Devastin drugs contraindicated in the following cases:

Patients with hypersensitivity to rosuvastatin or any excipients of the drug.

Patients with active liver disease, including prolonged increase in serum transaminase and have no cause, and when serum transaminase concentration increases more than 3 upper limits of normal levels (ULN).

Patients with severe renal failure (creatinine clearance

Patients with muscle disease.

Patients are taking cyclosporin.

Pregnant and lactating women, women may be pregnant without using appropriate contraception.

Be cautious when using

need to do liver enzyme test before starting statin treatment and in case of clinical indications require testing later.

History of muscle toxicity due to other HMG-CoA Reductase inhibitors or fibrates.

Conditions can cause increased drug concentration in plasma.

When using high doses, the Creatine Kinase (CK) enzyme is required because the risk of influence on the muscle.

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to the use of statin or fibrat before, a history of liver disease and/or drinking lots of alcohol, elderly patients (> 70 years old) have risk factors for muscle pattern, special patients and some patients. In these cases should consider benefits/risks and monitor patients clinically when treated with satatin. If the results of CK test> 5 times the upper limit of normal levels, do not start treatment with statin.

During statin treatment, patients need to notify when there are muscle manifestations such as muscle pain, muscle stiffness, muscle weakness ... When there are these manifestations, patients need to do CK test to take appropriate interventions.

Simultaneous use of rosuvastatin with HIV and hepatitis C (HCV) can increase the risk of muscle damage, the most seriousness is muscle pattern, kidney damage leading to kidney failure and can be fatal.

Medicinal interaction

Increased risk of muscle lesions when using rosuvastatin simultaneously with: gemfibrozil, other fibrat blood cholesterol medications, high doses of niacin (> 1g/day), Colchicin.

Do not use rosuvastatin with cyclosporin, vitamin K antagonists, antacids, erythromycin, contraceptive pill/hormone replacement therapy.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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