Devodil Remedica medicine for short -term treatment of anxiety, serious behavioral disorders (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Sulpiride
Ingredient Conscious disorders, mental disorders, anxiety, autism

Ingredient

Composition information	Content
Sulpiride	50mg

Uses

indications

Devodil drug indications for treatment in the following cases:

Short -term treatment for adult anxiety in case of not responding to the usual regimen. Select Dopamine D2 receptors in the brain. Sulpidi can be considered as an intermediary between neurolysis and antidepressants. Sulpidi is mainly used to treat in psychosis symptoms such as schizophrenia. The mood increased after a few days of treatment and lost all the frantic symptoms of the disease.

High doses of high doses control the positive symptoms of schizophrenia, but at low doses, it is active and agile for indifferent schizophrenia, cowering without contact with society. Sulpidi is different from the structural orchestras and does not keep the posture, does not affect the adenylcyclase system sensitive to dopamine, does not affect the adjustment of noradrenalin and 5-HT, almost no anti-cholininalase effect, does not work on Muscarin or GABA receptors.

Pharmacokinetics

absorption

Sulpidi absorbs slowly through the gastrointestinal tract, low bioavailability and depending on the individual. The peak concentration of sulpides reaches 3-6 hours after taking a dose.

Distribution

Quick distribution into tissues, through breast milk but through poorly brain blood barriers. The drug is associated with low plasma proteins (

Metabolism, excretion

Elimination through urine and feces, mainly in the form of unprovered (about 95%). Selling time is from 8 to 9 hours.

Before taking Devodil Remedica medicine for short -term treatment of anxiety, serious behavioral disorders (2 blisters x 10 tablets)

How to use

Devodil 50mg oral drug.

Dosage

Adults

Short -term treatment for adult anxiety in case of not responding to normal regimen. The daily dose is 50 - 150 mg for up to 4 weeks.

Children

Children over 6 years of age: serious behavioral issues (agitated, self -hurting, disorders) especially in autism syndrome. The daily dose is 5 - 10 mg/kg.

In children, oral solution will be more suitable.

Elderly

Dosage as for adults, but the starting dose is always low and increases gradually. The starting dose of 50 - 100 mg/time, 2 times a day, then increases to the effective dose.

Renal failure

Must reduce the dose or increase the distance between drug use depending on the clearinine clearance.

Creatinine clearance 30 - 60 ml/min: taking a dose equal to 2/3 of the normal dose.

Creatinine clearance 10 - 30 ml/minute: use a dose equal to 1/2 of normal dose.

The clearance of less than 10 ml/minute: using a dose equal to 1/3 of the normal dose.

In case of medium and severe kidney failure, Sulpides should not be used, if possible.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Clinical symptoms vary depending on the dose.

1 - 3 g: The state of gloomy, restlessness and rare symptoms of foreign tower.

3 - 7 g: more agitated, confused and extracurricular syndrome.

Over 7 g: In addition to the above symptoms can also coma and hypotension.

In general, the above symptoms often take after a few hours, coma can last up to 4 days.

Management: Sulpidi has no specific antidote. If new use, gastric lavage, active carbon (drugs that cause no effect), alkaline urine to increase the discharge of the drug. If necessary, Parkinson's use and supportive treatments and treatment of other symptoms.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Devodil 50mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Endocrine: increased blood prolactin.

Mental: Insomnia.

Nervous system: sedation or drowsiness, percentage disorders (these symptoms can often be reversed and disappear after using Parkinson's treatment): Parkinson, Run, restless sitting.

Digestive system: constipation.

Skin and subcutaneous tissue: scales.

Other: Liver enzyme, weight gain, breast pain, lots of milk in women.

Uncommon, 1/1000

Blood and lymphatic system: leukopenia.

Nervous system: Increase muscle tone, dysfunction, muscle tone.

vascular blood: lower blood pressure.

Digestive system: Excessive salivation.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Devodil 50mg drug contraindicated in the following cases:

Hypersensitivity to sulpides or any ingredients of the drug.

Chromium -preferred cells (known or suspicious) and acute porphyrin metabolism disorders.

Tumors are related to prolactin secretion, for example: pituitary gland secretion and breast cancer.

Coordinate with levodopa or anti -Parkinson (including Ropinirol).

Be cautious when used

Sulpidi can cause a distance of doses dependent, increasing the risk of severe ventricular arrhythmias (vertices). Check patient before treatment:

Slow heart rate below 55 beats/minute.

electrolyte imbalance, hypotension.

congenital qt.

Simultaneous treatment with slow heartbeat agents, hypokalemia, reduction in the heart or extension of QT.

In patients with dementia, using sulpides increases the risk of cerebrovascular events. Caution should be used in patients at risk of stroke. If there is an increase in body temperature of unknown origin (neurological malignant syndrome), stop using sulpid.

After more than 3 months of taking medication can cause slow movement disorders, Parkinson's medication may not be effective or worsen symptoms.

Using anti -psychotic drugs in elderly patients with dementia may increase the risk of death.

There has been a venous thrombosis when using anti -psychotic drugs.

Be cautious in patients or have a history of breast cancer family (due to prolactin increase side effects).

In patients treated with an anti -psychotic drug that is not typical, hyperglycemia, so patients with diabetes or have risk factors for diabetes, blood glucose should be monitored. In case of renal failure, dose reduction should be reduced.

Sedative can reduce seizures and cause seizures. Therefore, patients with a history of epilepsy should be carefully monitored when treated with sulpid.

In elderly patients, sulpides and other neuroleptics should be used very carefully.

In aggressive or agitated patients with impulsive behavior, sulpides can be used with sedation.

leukopenia, neutrophils and grain leukocytes have been reported when using anti -psychotic drugs (sulpides ...).

Blood disorders can cause unexplained fever or bacterial infection, need to check blood immediately.

Sulpidi has anti -acetylcholin effect, so it must be used carefully in patients with glaucoma (beaded), intestinal obstruction, congenital gastrointestinal stenosis, urinary retention, prostate hyperplasia. Caution in patients with hypertension, especially in the elderly and patients at risk of hypertension crisis. These patients must be fully monitored.

In patients with acute disorders, sulpides should only be used if the indicator is required to use it.

Sudden stopping of anti -psychotic drugs can cause nausea, vomiting, sweating and insomnia. Symptoms of neuropathy and non -autonomous movements (sitting, restless, muscular disorders and movement disorders) may also reappear. Therefore, the drug should be stopped gradually.

The drug contains lactose monohydrate. Patients with rare genetic problems of galactose tolerance, lactase deficiency or absorbent Glucose –Galactose should not use this drug.

The ability to drive and operate machinery

Devodil 50mg medicine can cause chicken sleep and distraction, so do not drive and operate machinery during the use of the drug.

Pregnancy

In vivo studies show a decrease in fertility related to the pharmacological effects of sulpidi (Prolactin effect) but do not see direct or indirect harmful effects on pregnancy, embryo/fetal development or after birth.

Infants have been exposed to anti -psychotic drugs (including sulpides) in the last three months of pregnancy are at risk of side effects, including symptoms of foreign tower, detoxification symptoms.

These symptoms (agitation, increase tone, hypotension, vibration, drowsiness, respiratory failure or eating disorders) may vary over time and severity. Therefore, babies need to be carefully monitored.

Lactation period

Sulpidi distributes large amounts of breast milk, so do not breastfeed while using the drug.

Interactive drug

Levodopa is contraindicated in combination with sulpiders due to Sulpidi and sedative antagonists.

Sucralfate or antacids containing aluminum or Magnesi hydroxyd reduces sulpid absorption. So use Sulpidi after taking antacids about 2 hours.

Lithi causes the ability to cause sulpided alleviates. When the first signs of neurotoxicity appear, both drugs should be discontinued.

Alcohol increases the sedative ability of the drug, so avoid drinking alcohol and alcoholic beverages while using sulpides.

Hematoplastic drugs: Increases the effect of lowering blood pressure and can cause vertical hypotension, it should be noted when coordinated with treatment.

Other central neurological inhibitors (pain relievers, cough inhibitors, most antagonists H1, Barbiturat, Benzodiazepin, other anxiety, other stresses, clonidin and related substances): Increasing neurological inhibitor can cause bad consequences, especially for drivers and machinery operating, it is important to note when coordinated.

There is an antagonist between the effects of Levodopa or Parkinson treatment (Ropinirol) and sedative. Contraindications for this combination.

Do not encourage simultaneous use with drugs that extend QT or cause electrolyte imbalance should also avoid combining. Combined with the following drugs, can extend the QT or twist:

Heart rhythmic drugs: beta blockers, calcium channel blockers that cause slow heart rate (diltiazem, verapamil), clonidin, guanfacin, digitalis).

Medications that cause hypokalemia: Diuretics hypokalemia, irritable laxative, amphotericin B intravenously, glucocorticoid, tetracosacides. Lower blood calcium should be adjusted.

Anti -arrhythmia IA: Quinidin, Dispopyramid.

Anti -arrhythmia type III: amiodaron, sotalol.

Drugs: Pimozid, SultoPrid, Haloperidol, Thioridazin, Methadon, Imipramin, Lithi, Bepridil, Cisapid, erythromycin IV, Cincamin IV, Halofantrin, Pentamidin, Sparfloxacin.

SultoPrid: Increasing risk of ventricular arrhythmia, especially twisted.

Storage

Storage in closed packaging, no more than 30 ° C, avoid light.

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