Dewom Atrazeneca treats large liver fluke disease, lung flukes (4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Triclabendazole
Ingredient Infections / infections, liver fluke infection, lung fluke, parasites, virus infections (viral diseases), fungal infections

Ingredient

Thành phần cho 1 viên

Composition information	Content
Triclabendazole	250mg

Uses

indications

Dewom drugs are indicated in the following cases:

Treatment liver fluke (SLGL) is caused by Fasciola Hepatica/Fasciola Gigantica.

triclabendazole and its sulfoxide metabolites are easily absorbed into the skin's skin. Reducing the movement of adult and immature form of parasites monitored after 24 hours in test tubes when in contact with triclabendazole. This phenomenon is related to an important change in the skin's voltage.

Sulfoxide metabolism seems to be used differently but more effectively on bacterial movement rather than the original triclabendazole. Therefore, it is likely that this drug is mainly effective through sulfoxide metabolites that are the majority in human plasma.

triclabendazole propionate and acetate are formed from glucose. It inhibits the production of protein hydrolysis from mature worms and has not matured, because of the function of the function of the sub -trailer. Therefore, the drug inhibitors conducting skin cell transmission on the surface of the skin. Triclabendazole does not work on the circular worm.

pharmacokinetics

absorption:

Oral

, triclabendazole is absorbed through the stomach; Absorption increased two to three times when Triclabendazole was used after a fat -rich meal.

Distribution:

triclabendazole and metabolites it reaches high concentrations in the bile ducts, thereby it excreted in the intestine for a few days; At least 1 % triclabendazole orally excreted in breast milk.

Biology:

triclabendazole is oxidized into sulfoxide (main metabolites) and sulfone (less than the first 24 hours after drinking.

Time to reach the peak concentration: approximately 8 hours.

Era:

approximately 95% triclabendazole orally (constant or main metabolic form) is eliminated through feces. Approximately 2% is eliminated through urine.

Before taking Dewom Atrazeneca treats large liver fluke disease, lung flukes (4 tablets)

How to use

oral drugs, only for adults and children over 4 years old.

Dosage

Large liver fluke:

10 mg/kg can take a single dose. If necessary, the dose can be repeated after 2 weeks or after 6 months.

Lung flukes:

20 mg/kg body weight divided into two doses.

Triciabendazole absorption may increase if used after meals, especially when food is fat.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Dewom, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache .

digestive: shrinking, disease diarrhea .

Uncommon, 1/1000

No information.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dewom drugs contraindicated in the following cases:

Patients are known to be hypersensitively to any ingredients of the drug.

Be cautious when used

Treatment of anti -spasms for 5 to 7 days after treatment with triclabendazole causes analgesic due to increased excretion through the bile duct of dead parasites.

Be careful to use medication for patients with extension of QT or a history of long -term QT symptoms due to drug use capable of acting on the QT range.

In the study conducted on dogs, extending the QT range on the electrocardiogram was recorded in a few animals. This effect is likely to be related to the metabolism of triclabendazole. This phenomenon does not see the research performed in humans. However, it is advisable to continue vigilant, especially for those who are at risk (including the elderly, the impaired person of the liver and kidney function).

triclabendazole is also used carefully in the subject of glucose-6-phosphate-dehydrogenase enzyme deficiency due to hemolytic ability.

Due to the containing lactose, this drug is not recommended in congenital galactose hyperemia, poorly absorbent glucose and galactose syndrome or lactase deficiency.

The ability to drive and operate machinery

should notify all subjects at risk of dizziness during treatment that can reduce driving ability or use machinery.

Pregnancy

There is no monster when conducting research on rats and rabbits with triclabendazole.

Other benzimidazols such as Mebendazole, Flubendazole and Albendazole cause teratogenicity in some animals.

Clinically, there has not been a reliable data to assess the ability to cause defects or fetal toxins when the drug is used during pregnancy.

triclabendazole is only used in pregnant women when it is really necessary and preferably after the first quarter of pregnancy.

The period of breastfeeding

is not sure whether triclabendazole will be secreted into breast milk, need to be cautious when using triclabendazole during breastfeeding. Recommendation should only be breastfeeding after 72 hours of medication.

Drug interaction

cisapride, pimozide, quinidine: The risk of increased ventricular rhythmic disorders, especially twisted (inhibits metabolism through the liver of this drug). Make sure at least 24 hours when stopping the triclabendazole and start taking this medicine and vice versa.

Storage

Store in a cool, dry place below 30 ° C. Avoid light.

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