Dexalevo Drop CPC1HN eye drops treat eye infections, conjunctivitis (5ml)

Dosage form Jar
Specifications Levofloxacin, dexamethasone phosphate

Ingredient

Composition information	Content
Levofloxacin	5mg
Dexamethasone phosphate	1mg

Uses

indications

Dexalevo Drop drugs are indicated in the following cases:

dexalevo-drop is indicated for eye inflammation in the response to steroids and is indicated for corticosteroids and when infected, conjunctivitis caused by bacterial strains sensitive to levofloxacin:

Gram -positive bacteria: Corynebacterium, Staphylococcus aureus, Staphylococcus Epidermidis, Streptococci Group C, F, and G, Viridans Streptococci or Streptococcus Pneumoniae. LWOFFII, Haemophilus Influenzae, Serratia. They are also indicated in the case of chronic pre -chronic dug and corneal damage due to chemicals, radiation or heat burns caused by foreign objects. The use of a mixture of anti -infection components is indicated when the risk of shallow infections in the eye is high or when it is possible to see some dangerous bacteria in the eye.

Pharmacology

Pharmacological group: Fluoroquinolon and glucocorticoid antibiotic group combination.

ATC: S01CA01.

Levofloxacin is a broad -spectrated synthetic antibiotic belonging to the Quinolon group (fluoroquinolon). Like other fluoroquinolon, levofloxacin has bactericidal effects due to inhibiting Topoisomerase II (DNA-GYRASE) and/or Topoisomerase IV are essential enzymes of the catalyst participating in the process of copying, code and repair of DNA of bacteria.

Levofloxacin is the isomorphic S-(-)-Isomer of Ofloxacin, it has a strong bactericidal effect of 8-128 times higher than the D-Isomer isomer and about 2 times the effect of Ofloxacin Racemic.

levofloxacin as well as other fluoroquinolones are broad -spectrum antibiotics, which act on many gram -negative and gram -positive bacteria strains. Levofloxacin (as well as sparfloxacin) works on gram -positive bacteria and anaerobic bacteria than other fluoroquinolon (such as Ciprofloxacin, Emoxacin, LomeFloxacin, Norfloxacin, Ofloxacin), however Levofloxacin and Sparfloxacin have In VitroSt on Pseudonas Aeruginosa is weaker than Ciprofloxacin.

The effect of levofloxacin:

In vitro sensitive bacteria and clinical infections:

Gram -negative bacteria: En Chlamydia pneumoniae, Mycopasma pneumoniae. Fusobacterium, peptostreptococcus, propionibacterium.

Gram -positive bacteria: Enterococcus Faecalis

Anaerobic bacteria: Bacteroides Fragilis, Prevotella

Levofloxacin resistant bacteria:
Gram-positive bacteria: Enterococcus Faecalis, Staphylococus aureus meti-r, Staphylococus coagulase negative meti-r. Due to the mechanism of action, there is usually no cross -resistant between levofloxacin and other antibiotics.
dexamethason is fluomethylprednisolon, synthetic glucocorticoid. Glucocorticoid works by binding to the receptor in the cell, transferring into the cell nucleus and there affects some code -translated genes. Glucocorticoids also have some direct effects without intermediaries. Dexamethasone has the main effects of glucocorticoids are anti -inflammatory, anti -allergic and immunosuppressive inhibitors, while electrolyte balance effect is very few .. In terms of anti -inflammatory activity, Dexamethasone is 30 times stronger than hydrocortison, stronger than prednisolone 7 times. Dexamethason is used on the spot to look up into the conjunctiva, outer ear canal or nasal mucosa to treat inflammatory or allergies in the outer ear or eye. Corticosteroid therapy does not cure the need to identify or eliminate the cause of inflammation if possible.
Dynamic pharmacokinetics

Levofloxacin plasma concentration measured over 15 healthy mature volunteers at different times in a 15 -day -eyed treatment with 0.5% levofloxacin that shows levofloxacin concentration in plasma 1 hours after the first dose in the first dosage from 0.86 ng/ml on the first day of the first day to 2.05 ng/ml/day. Maximum levofloxacin concentration is 2.25 ng/mL measured on the 4th day after 2 days of use of 2 hours apart in all 8 doses/day. Maximum levofloxacin concentration is from 0.94 ng/ml/day 1 to 2.15ng/ml/day 15th 1000 times lower reports after taking levofloxacin system. Levofloxacin concentration in tears measured in 30 mature and healthy volunteers in different times is from 34.9 to 221.14g/ml during 60 minutes after single dose.
After being used on the spot, dexamethasone is absorbed into the aquarium, cornea, iris, veins, lashes and retina. Absorption is entirely possible but only significant when using the dose is higher or in expanded pediatric treatment. Dexamethasone sodium phosphate is quickly transformed into dexamethasone after use. Up to 77% dexamethasone is linked to protein. More than 60% of dexamethasone is eliminated through urine within 24 hours. Dexamethason's semi -waste time is approximately 3.6 ± 0.9 hours.

Before taking Dexalevo Drop CPC1HN eye drops treat eye infections, conjunctivitis (5ml)

How to use

To avoid the infection into the tip of the small bottle and the solution, do not let the small tip touch the eyelids, the area around the eyes or any objects.

To prevent the drug absorbed through the nasal mucosa, especially in infants or young children by pressing with their fingers into the tears in the inner corner of the eye for 2-3 minutes after taking the drug to prevent the drug from giving the drug through tears. After opening the lid, it is necessary to remove the first drop before each medication.

If there is more than one in place used on the spot, the preparations must be used at least 5 minutes apart. Eintments should be used last. Compliance with the doctor's instructions on dosage, number of use and medication time. Do not stop using the drug without consulting the doctor. Do not use overdue drugs.

Dosage

Dosage in case of treatment:

Day 1 and 2: 1-2 drops/time into the eye 2 hours, 8 times a day.

From 3 to 7: 1-2 drops/time 4 hours apart, 4 times a day. Caution should not stop treating too early.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

Adultery effects when using steroid and antibacterial combination drugs may be due to steroid ingredients, antibacterial ingredients or mixed mixed. There is no accurate data on the frequency of adverse effects.

The side effects often occur with eye drops containing levofloxacin are: reduce temporary vision, fever, feeling of heterosexuals in the eyes, headache, hot eyes, pain or discomfort in the eyes, sore throat, fear of light. These side effects appear in about 1-3 % of patients using the drug. Cataract below the following; And slowly wound.

Fungal infections in the cornea especially occur after long -term steroids. Once treated with steroids must consider the possibility of fungal infections in any case with prolonged corneal ulcer.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dexalevo Drop drugs contraindicated in the following cases:

hypersensitively to quinolon, dexamethason or any ingredient of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Dexalevo-Drop solution should not be injected in the conjunctiva or should not be put directly into the eye room. Levofloxacin in dexalevo-des can make the eyes more sensitive to conventional light, should wear sunglasses and avoid direct light can reduce discomfort when used.

should be wary of corneal fungal infection after prolonged steroids. Like other antibiotic preparations, this long -lasting medication can lead to multiple sensitive microorganisms including mushrooms. If the superinfection occurs, the appropriate treatment should be started. When you need to prescribe many times, or whenever a clinical examination is needed, it is necessary to examine patients with the support of exaggerated tools such as slot lights and when needed to dye fluorescent.

The effect of the drug on the ability to drive and operate machinery

The drug causes temporary vision reduction and other side effects that affect the ability to drive and operate the machine, so be careful when used or should not be used when doing these jobs.

Use drugs for women during pregnancy and lactation

Pregnant women:

There is no safe studies when using eye drops containing levofloxacin and dexamethasone for pregnant women, so it is cautious when used for this object. The drug should only be used if it is more likely to be more beneficial than the risk for the fetus.

breastfeeding women:

Due to the ingredients excreted by breast milk, so it is necessary to be cautious when using dexalevo-des

Drug interaction

There is no accurate study of levofloxacin interaction in the form of eye drops with other drugs. However, when using a number of body quinolones, it causes anhophyllin concentration, interfering with caffeine metabolism, increasing the effects of warfarin oral anticoagulant drugs and its derivative, related to temporary increased plasma of creatinine in patients with cyclosporin oral patients when used simultaneously.

dexamethasone sodium phosphate is similar to daunorubicin, doxorubicin, vancomycin, not used in combination with these drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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