Dexamethason Kabi 4mg drug used in heavy allergies (10 tubes)

Dosage form 10 -tube box
Specifications Dexamethasone phosphate
Ingredient Fresenius Kabi Bidiphar Joint Stock Company

Ingredient

Composition information	Content
Dexamethasone phosphate	4mg

Uses

indications

Dexamethason Kabi 4mg drug is indicated in the following cases:

Use emergency use in cases of severe allergies, surgical shock, cerebral edema, adrenal insufficiency. Dexamethasone acts by connecting the receptor in the cell, transferring into the cell nucleus and there has affected some translated genes.

pharmacokinetics

dexamethason absorbed well at the position of the drug and then distributed into all tissues in the body. The drug through the placenta and a small amount of milk. After injection, dexamethasone sodium phosphate hydrolyzes quickly into dexamethasone. The drug is highly absorbed in the liver, kidneys and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine. The half -life of dexamethasone is 36 - 54 hours, so the drug is especially suitable for diseases that need glucocorticoid -acting glucocorticoids.

Before taking Dexamethason Kabi 4mg drug used in heavy allergies (10 tubes)

How to use

intravenously or intravenously, injection in joints.

Dosage

This drug is only used as prescribed by a physician.

intramuscularly or intravenously, injected in joints. The dosage depends on the disease and the response of the patient. The dosage of sodium phosphate dexamethasone is calculated according to dexamethasone base in the ratio: 1.1 mg of dexamethasone sodium phosphate corresponding to about 1 mg of dexamethasone phosphate; 1.2 mg dexamethasone phosphate corresponding to 1 mg of dexamethasone base.

allergies

The first day, intramuscularly dexamethasone phosphate 4 - 8 mg (corresponding to dexamethasone 3.33 - 6.66 mg); On the 2nd and 3rd day, drink dexamethasone 3 mg divided into 2 times; On the 4th day, taking 1.5 mg divided into 2 times; Day 5 and 6, take 1 single dose daily 0.75 mg and stop the drug.

Shock (for reasons)

dose of 1 - 6 mg/kg dexamethasone phosphate (equivalent to 0.83 - 5 mg/kg dexamethasone) intravenously once or 40 mg (equivalent to 33.3 mg dexamethasone) intravenously 2 - 6 hours/time, if necessary.

Alternatively, at first intravenously 20 mg (equivalent to 16.67 mg dexamethasone), then continuous intravenous infusion 3 mg/kg/24 hours (equivalent to 2.5 mg/kg/24 hours dexamethasone).

Severe shock treatment is used by 2-6 mg/kg dexamethasone phosphate (equivalent to 1.67-5 dexamethasone) intravenous intravenously, minimum injection time is 3-5 minutes. Continue to take high doses until the patient is stable (usually not more than 48 - 72 hours).

brain edema

Intravenous injection of 10 mg of dexamethasone phosphate (equivalent to 8.33 mg dexamethasone), followed by 4 mg intramuscular injection (equivalent to 3.33 mg dexamethasone) apart 6 hours/time, until the symptoms of cerebral edema. The response is usually clearly within 12 - 24 hours and the dosage may decrease after 2-4 days and stop gradually over 5-7 days.

When possible, replace intramuscularly with oral dexamethasone (1 - 3 mg/time, drink 3 times/day). For patients with brain tumors that cannot be operated or relapsed. The maintenance dose is 2 mg dexamethasone dexamethasone (equivalent to 1.67 mg of dexamethasone), intramuscular or intravenous, 2-3 times/day, may be effective to reduce the symptom of intracranial pressure.

injection in joints

knee joints 2 - 4 mg (equivalent to 1.67-3.33 mg dexamethasone).

Smaller joints: 0.8 - 1 mg (equivalent to 0.67-0,833 mg dexamethasone).

Animal bags: 2 - 3 mg (equivalent to 1.67-2.5 mg dexamethasone).

Ribbed: 0.4 - 1 mg (equivalent to 0.333-0,833 mg dexamethasone).

Soft tissue: 2 - 6 mg (equivalent to 1.67-5 mg dexamethasone).

Can be injected repeatedly 3-5 days/time (epidemic bag) or 2-3 weeks/time (joint). Need to ensure absolute sterility.

Children: intramuscularly, intravenously, 6 - 40 micrograms/kg (corresponding to 5 - 33.3 micrograms/kg dexamethasone), 1-2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

causes acute poisoning. There is no specific antidote.

Handling

Anaphylaxis or hypersensitivity reactions can be treated with ephedrine, artificial respiration and aminophylin. Patients should be kept warm and quiet.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Dexamethason Kabi 4mg, you may experience unwanted effects (ADR).

Unknown frequency ADR

Electrolyte disorders: Hypotension, sodium and water that causes hypertension and edema.

Endocrine and metabolism: Cushing syndrome, ACTH excretion, adrenal atrophy, glucid tolerance, menstrual disorders.

Muscle, bone: Muscle atrophy, osteoporosis, pathological fracture, spine cracking, sterile bone necrosis.

digestive: peptic ulcer, bleeding ulcer, barrel ulcer, acute pancreatitis.

Skin: Skin atrophy, erythema, bruising, him.

nerve: insomnia, refreshment.

How to handle

Be cautious when indicated and use the lowest dose to work, constantly stopping the drug suddenly or does not reduce the dose too fast when used for a long time or high doses, focusing on drug interaction when combined with other drugs.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dexamethason Kabi 4mg Contraindicated in the following cases:

Hypersensitivity to dexamethason.

Systemic fungal infections, local virus infections, or tuberculosis, gonorrhea infections have not controlled antibacterial and joints severely destroyed.

Be cautious when used

In patients with infections or suspected infections must be treated with specific antibacterial drugs is necessary first, due to immunosuppressive effects, dexamethasone can cause dramas and spread infections.

In people with meningitis, dexethasone must be used before taking specific antibacterial drugs.

In people with osteoporosis, or new surgery, mental disorders, stomach ulcers, duodenum, diabetes, hypertension, heart failure, kidney failure, tuberculosis should be closely monitored and actively treated those diseases if needed to use dexamethasone.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

dexamethasone can inhibit the adrenal glands in babies if the mother uses the medication for a long time. Using glucocorticoid before premature birth has shown to protect against the risk of neonatal respiratory insufficiency and pulmonary - bronchial disorders due to premature birth.

Breastfeeding period

Dexamethason into breast milk is at risk for breastfeeding.

Drug interaction

Barbiturat, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Ephedrine, Aminoglutethimide increases corticosteroid removal should reduce treatment effects.

corticosteroids against the effects of hypoglycemia (including insulin), hypotension and diuretics.

Salicylate clearance increases when used simultaneously with corticosteroids, so when corticosteroids are susceptible to salicylate poisoning.

Do not use in combination with daunorubicin, doxorubicin, vancomycin because dexamethasone sodium phosphate is corresponding to these drugs.

Storage

Storage in closed packaging, temperature below 30⁰C.

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