Dexamethason Kabi injection solution is used in case of severe allergy, shock due to surgery (50 tubes)

Dosage form Box of 50 tubes x 1ml/tube
Specifications Dexamethasone phosphate

Ingredient

Composition information	Content
Dexamethasone phosphate	4mg/ml

Uses

Indications

Dexamethason Kabi 4 mg drug is indicated in the following cases:

Use emergency use in cases of severe allergies, surgical shock, cerebral edema, adrenal insufficiency. Dexamethasone acts by connecting the receptor in the cell, transferring into the cell nucleus and there has affected some translated genes.

Pharmacokinetics

absorption

The drug is well absorbed through the gastrointestinal tract, also well absorbed at the position of the drug. The drug is highly absorbed in the liver, kidneys and adrenal glands.

Distribution

The drug is distributed into all tissues in the body, the drug can be given the placenta and a small amount through breast milk. The drug is also linked to plasma proteins up to 77% and mainly albumin.

Metabolism

Metabolic drugs in the liver slowly.

Elimination

Eliminating drugs through urine, mostly in the form of non -conjugated steroids. Selling time is about 36 - 54 hours.

Before taking Dexamethason Kabi injection solution is used in case of severe allergy, shock due to surgery (50 tubes)

How to use

intravenously or intravenously, injection in joints.

Dosage

This drug is only used as prescribed by a physician.

Intramuscularly or intravenously, injected in joints: The dosage depends on the disease and the response of the patient. The dosage of sodium phosphate dexamethasone is calculated according to dexamethasone base in the ratio: 1.1 mg of dexamethasone sodium phosphate corresponding to about 1 mg of dexamethasone phosphate; 1.2 mg dexamethasone phosphate corresponding to 1 mg of dexamethasone base.

allergies

First day: Intramuscularly Dexamethasone Phosphate 4 - 8 mg (corresponding to dexamethasone 3.33 - 6.66 mg). Drugs.

dose of 1 - 6 mg/kg dexamethasone phosphate (equivalent to 0.83 - 5 mg/kg dexamethasone) intravenously or 40 mg (equivalent to 33.3 mg dexamethasone) intravenously 2 - 6 hours/time, if needed.

Other ways, at first intravenously 20 mg (equivalent to 16.67 mg dexamethasone), then continuous intravenous infusion 3 mg/kg/24 hours (equivalent to 2.5 mg/kg/24 hours dexamethasone).

Severe shock treatment is used 2 - 6 mg/kg dexamethasone phosphate (equivalent to 1.67 - 5 dexamethasone) intravenous intravenous injection, minimum injection time is 3 - 5 minutes. Continue to take high doses until the patient is stable (usually not more than 48 - 72 hours).

Cerebral Phu

Intravenous injection of 10 mg of dexamethasone phosphate (equivalent to 8.33 mg dexamethasone), followed by 4 mg intramuscular injection (equivalent to 3.33 mg dexamethasone) apart 6 hours/time, until the symptoms of cerebral edema. The response is usually clearly within 12 - 24 hours and the dosage may decrease after 2-4 days and stop gradually over 5 -7 days. When possible, replace intramuscularly with oral dexamethasone (1 - 3 mg/time, drink 3 times/day).

For patients with non -surgical or recurrent brain tumors: The maintenance dose is dexamethasone phosphate 2 mg (equivalent to 1.67 mg dexamethasone), intramuscular or intravenous, 2-3 times/day, can be effective reducing symptoms of intracranial pressure.

injection in joints:

knee joints 2 - 4 mg (equivalent to 1.67 - 3.33 mg dexamethasone).

Smaller joints: 0.8 - 1 mg (equivalent to 0.67 - 0.833 mg Dexamethasone).

Animal bags: 2 - 3 mg (equivalent to 1.67 - 2.5 mg dexamethasone).

Ribbed: 0.4 - 1 mg (corresponding to 0.333 - 0.833 mg Dexamethasone).

Soft tissue: 2 - 6 mg (equivalent to 1.67 - 5 mg dexamethasone).

Can be injected repeatedly 3-5 days/time (epidemic bag) or 2-3 weeks/time (joint). Need to ensure absolute sterility.

Children

intramuscularly, intravenously, 6 - 40 micrograms/kg (corresponding to 5 - 33.3 micrograms/kg dexamethason), 1-2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

causes acute poisoning. There is no specific antidote.

Handling

Anaphylaxis or hypersensitivity reactions can be treated with ephedrine, artificial respiration and aminophylin. Patients should be kept warm and quiet.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The reactions encountered

Electrolyte disorders: Hypotension, sodium and water causing hypertension and edema. Thick duodenum, bleeding ulcers, barrel ulcers, acute pancreas.

Be cautious when indicated and use the lowest dose to work.

Stop sudden or not decrease the dose too fast when long -term use or high doses. Focus on drug interactions when combined with other drugs.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dexamethason Kabi 4 mg is contraindicated in the following cases:

Hypersensitivity to dexamethasone.

Be cautious when used

In patients with infections or suspected infections: First, need to be treated with specific antibacterial drugs. Due to immunosuppressive effects, dexamethasone can cause drama and spreading infections.

In people with meningitis: Dexamethasone is needed before taking specific antibacterial drugs.

In people with osteoporosis, or new surgery, mental disorders, stomach ulcers, duodenum, diabetes, hypertension, heart failure, kidney failure, tuberculosis: need to closely monitor and actively treat these diseases if needed to use dexamethasone.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

dexamethasone can inhibit the adrenal glands in babies if the mother uses the medication for a long time. Using glucocorticoid before premature birth has shown to protect against the risk of neonatal respiratory insufficiency and pulmonary - bronchial disorders due to premature birth.

Breastfeeding period

Dexamethason into breast milk is at risk for breastfeeding.

Drug interaction

Barbiturat, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Ephedrine, Aminoglutethimide increases corticosteroid removal should reduce treatment effects.

corticosteroids against the effects of hypoglycemia (including insulin), hypotension and diuretics.

Salicylate clearance increases when used simultaneously with corticosteroids, so when corticosteroids are susceptible to salicylate poisoning.

Do not use in combination with daunorubicin, doxorubicin, vancomycin because dexamethasone sodium phosphate is corresponding to these drugs.

Storage

Store in closed packaging, temperatures below 30⁰C.

Other drugs

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