Dexamethason Quapharco medicine treats severe allergies, urticaria, asthma (10 blisters x 30 tablets)

Dosage form Box of 10 blisters x 30 tablets
Specifications Dexamethasone

Ingredient

Composition information	Content
Dexamethasone	0.5mg

Uses

Indications

Dexamethason drug indicated in the following cases:

Non -specific therapy with steroids, when needed to be active, such as treatment of asthma, severe allergy, post -blood transfusion reaction, laryngitis. Addison). Fluomethylprednisolon, synthetic glucocorticoid, almost insoluble in water. The glucocorticoids acting by binding to the receptor in the cell, transferring into the cell nucleus and there has affected some translated genes.

Glucocorticoids also have some direct effects, may not be intermediaries to connect to the receptor.

Dexamethasone has the main effects of glucocorticoids are anti -inflammatory, anti -allergic and immunosuppressive inhibition, while the effect of electrolyte balance is very few. In terms of anti -inflammatory activity, Dexamethason is stronger than Hydrocortisone, 7 times stronger than prednisolon.

Dexamethason is used, intramuscularly, injected, inhaled or applied on the spot, to treat diseases that corticosteroids are specified (except for adrenal insufficiency) such as bleeding, trauma, surgery, or infection, brain edema due to brain tumors, arthritis and soft tissue such as rheumatoid arthritis, short -term treatment for self -acute, vascular, severe acute, chronic acute, severe acute, severe acute, chronic acute. like bronchial asthma or serum disease.

Dexamethasone use must be combined with the treatment of systemic antibiotics and supportive measures, when needed. Dexamethason is also used on the spot to apply to the conjunctiva, outer ear canal or nasal mucosa to treat inflammatory symptoms or allergies in the outer or eye or eye. Eye corticosteroid therapy does not cure the disease, so it is necessary to identify or eliminate the cause of inflammation, if possible.

With pharmacological dose, dexamethasone used body inhibits the pituitary gland release corticotropin (ACTH), causing the adrenal shell to stop the endogenous corticosteroid hormone (causing secondary adrenal implants). If it is necessary to treat with long -term glucocorticoids, only use the drug at the lowest possible doses and usually only use as a medication for other treatment. When stopping the body therapy with pharmacological doses, it is necessary to reduce the dose gradually, until the function of the axis of the lower - saddle - adrenal is recovered.

pharmacokinetics

In general, the corticosteroids are well absorbed from the digestive tract, and are also well absorbed at the position of medication and then distributed to all tissues in the body.

The drug through the placenta and a small amount of milk. After injection, dexamethasone sodium phosphate hydrolyzed quickly into dexamethasone.

When an intravenous injection of 20 mg, the peak concentration appears in plasma after 5 minutes. The drug is also associated with plasma proteins (up to 77%) and mainly albumin.

The drug is highly absorbed in the liver, kidneys and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine, most in the form of non -conjugate steroids.

Half of the lifetime of plasma is 3.5 - 4.5 hours, but when it comes to effects, often use half a biological life. The half -life of dexamethasone is 36 - 54 hours, so the drug is especially suitable for diseases that need glucocorticoid -acting glucocorticoids.

Before taking Dexamethason Quapharco medicine treats severe allergies, urticaria, asthma (10 blisters x 30 tablets)

How to use

oral drugs. Should take medicine after eating.

Dosage

Dosage should vary depending on the patient, based on illness and response of the patient.

To minimize the side effects, the smallest dose should be used to effectively treat.

Anti -inflammatory activity of 750 micrograms is equivalent to about 5 mg of prednisolon.

Initial dose: Take 0.75 - 9 mg/day, depending on the disease and usually divided into 2-4 doses.

Children: Take 0.024 - 0.34 mg/kg/day, or 0.66 - 10 mg/m2/day divided into 4 doses.

Secondary adrenal insufficiency because of the drug, may be due to stopping the drug too fast, and may be limited by reducing the dose slowly after weeks or months depending on the dose, treatment time, but it may still exist for months after stopping the drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no specific antidote. There is no indication for the treatment of chronic poisoning, unless the patient is too sensitive to corticosteroids, causing pathology; At that time, it is necessary to treat symptoms.

Anaphylaxis or hypersensitivity reactions can be treated with cepinephrin, artificial respiration and aminophylin. Patients should be kept warm and quiet.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using dexamethason often has unwanted effects (ADR) such as:

Common, ADR> 1/100

Electrolyte disorders: Hypotension, sodium and water causing hypertension and edema. duodenum, bleeding ulcers, ulcers, acute pancreatitis

Hypersensitivity, sometimes anaphylaxis, white blood cells, thrombosis, weight gain, appetite, nausea, hard -working, hiccup, sterile abscess.

Symptoms and signs of stopping drugs: Reducing too fast the drug after prolonged treatment can lead to acute adrenal failure, lower blood pressure and die. Stop drugs sometimes like relapse.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dexamethasone drugs contraindicated in the following cases:

hypersensitivity to dexamethasone or other components of the preparation; Systemic fungal infections, local virus infections or tuberculosis, gonorrhea infections are not controlled by antibacterial and joints.

Be cautious when using

In patients with infections or suspected infections, special attention and treatment with specific antibacterial drugs are necessary first, due to immunosuppressive effects, dexamethasone can cause drama and spread of infections.

However, infected meningitis need to take dexamethasone before taking specific antibacterial drugs to prevent encephalitis due to reacting with bacterial pieces that have been destroyed by antibacterial drugs.

In people with osteoporosis, or new intestinal surgery, mental disorders, peptic ulcer, diabetes, hypertension, heart failure, kidney failure, tuberculosis, it is necessary to closely and actively treat those diseases if needed to use dexamethasone.

Use drugs for women during pregnancy and lactation

Pregnancy

Glucocorticoids have the potential to cause teratogenic animals. However, that is not entirely true for people.

The drug may reduce the weight of the placenta and the fetal weight. The drug can also inhibit the adrenal glands in newborns if the mother uses the drug for a long time.

Using glucocorticoid before premature birth has shown to protect against the risk of neonatal respiratory failure syndrome and bronchial dysplasia - bronchial due to premature birth.

Breastfeeding period

dexamethason into breast milk and at risk for breastfeeding.

The effect of the drug on driving and operating machinery

No data.

Medicinal interaction

Barbiturat, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Ephedrin, Aminoglutethimid can increase corticosteroid removal, which reduces the treatment effect.

corticosteroids against the effects of hypoglycemia (including insulin), hypotension and diuretics.

corticosteroid increases the hypotension effect of acetazolamid, diuretic thiazids, carbenoxolon. The effect of anticoagulant cumric derivatives can increase when used with corticosteroids, so it is necessary to closely check the prothrombin time to avoid spontaneous bleeding.

Salicylate clearance increases when used simultaneously with corticosteroids, so when corticosteroids are susceptible to salicylate poisoning. Diuretics reduce potassium potassium (eg thiazid, furosemid) and amphotericin B may increase the effect of reducing blood potassium of glucocorticoids.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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