Dexamethasone 0.5mg Mekophar treats asthma, severe allergic disease (10 blisters x 20 tablets)

Dosage form Box of 10 blisters x 20 tablets
Specifications Dexamethasone acetate
Ingredient Mekophar

Ingredient

Composition information	Content
Dexamethasone acetate	0.5mg

Uses

indicated

Dexamethasone indicated treatment in the following cases:

Anti -inflammatory, non -specific therapy with steroids, when needed actively treatment, such as asthma treatment, severe allergic disease, post -blood transfusion reaction, laryngitis.

Used in combination with other treatments in the brain edema, in shock due to various causes.

Steroid prevention in surgery when storing glucocorticoid is considered insufficient, except for the elongated adrenal shell (Addison disease).

Use dexamethason to diagnose and test the Cushing syndrome, distinguish the Cushing (adrenal hyperplasia due to the defects from the pituitary gland) and other forms of the Cushing syndrome (due to the excretion of ACTH from non -pituitary tumors or cortisol secretion from adrenal gland tumors).

Dexamethason is also applied a lot to prevent nausea and vomiting caused by cancer chemotherapy.

Pharmacokic

dexamethason is Fluomethylprednisolon, synthetic glucocorticoid. The glucocorticoids act on the receptor in the cell, the transferred to the cell nucleus and there affects some of the translated genes. Glucocorticoids also have some direct effects, which may not be intermediaries connected to the receptor.

Dexamethasone has anti -inflammatory, anti -allergic and immunosuppressive effects. In terms of anti -inflammatory activity, Dexamethason is stronger than Hydrocortison, 7 times stronger than Prednisolon.

pharmacokinetics

dexamethasone is well absorbed through the digestive system, quickly distributed to the tissue in the body.

dexamethasone through the placenta and a small amount of milk.

When taken, the time to reach the peak concentration in plasma is 1-2 hours. The drug is linked to plasma proteins (up to 77%) and mainly albumin. The drug is highly absorbed in the liver, kidneys and adrenal glands.

Metabolic in the liver slowly, excreting mainly through urine (65% of the excretory dose through urine within 24 hours), most in the form of non -unimportant steroids. Half of the plasma of the drug is 3.5 - 4.5 hours, the sale time is 36 - 54 hours.

Before taking Dexamethasone 0.5mg Mekophar treats asthma, severe allergic disease (10 blisters x 20 tablets)

How to use

Dexamethasone is orally used. Drink at meals.

Dosage

Dosage should vary depending on the patient, the degree of inflammation, wide inflammation, inflammatory position and response of the patient. To minimize side effects, the minimum dosage should be used to effectively treat.

Initial dose: 0.75 - 9 mg/day depending on the disease and usually divided into 2-4 times. The disease is less severe, which can be used lower than 0.75 mg/day, and severe illness may need higher doses of more than 9 mg/day.

Children: Take 0.02 - 0.3 mg/kg/day, or 0.6 - 10 mg/open/day divided into 3-4 times.

Do not stop the drug suddenly but have to gradually reduce the dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Use supportive measures and symptomatic treatment.

Anaphylaxis or hypersensic reactions can be treated with epinephrin, artificial respiration and aminophyllin.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects (ADR) when using Dexamethasone that you may encounter:

Common

Electrolyte disorders: Hypotension, sodium and water causing hypertension and edema. colon, ulcers bleeding, ulcers, acute pancreatitis

Hypersensitivity, sometimes anaphylaxis, leukocytes, thrombosis, weight gain, appetite, nausea, difficulty in, hiccup, sterile abscess. Stop drugs sometimes like relapse.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dexamethasone drugs are contraindicated in the following cases:

Hypersensitivity to dexamethasone and any ingredients of the drug.

Caution when using

In patients with infections or suspect infections, special attention and treatment with specific antibacterial drugs are necessary first, due to immunosuppressive effects, dexamethasone can cause drama and spread infections. However, infected meningitis need to use dexamethason before taking specific antibacterial drugs to prevent encephalitis due to reaction to the bacterial body pieces that have been destroyed by antibacterial drugs.

In people with osteoporosis or new surgery, mental disorders, peptic ulcer, diabetes, hypertension, heart failure, kidney failure, tuberculosis, it is necessary to closely monitor and actively treat those diseases if needed to use dexamethasone.

Patients with Galactose intolerance due to genetics, deficiency of lactase enamel or malposure - Galactose should not use this drug.

The effect of the drug on the ability to drive and operate machinery

People who often drive or operate machinery should use drugs?

Be cautious when using drugs for drivers and machinery.

Using drugs for women during pregnancy and lactation

Women during pregnancy should use drugs?

Follow the instructions from the doctor. The drug should only be used when the benefits are out of risks that may occur. Be cautious when used for pregnant women.

Should breastfeeding women take medicine?

Do not breastfeed while using the drug. Follow the instructions from the doctor.

Drug interaction

Avoid simultaneous use of dexamethasone with the following drugs: Everolimus, Natalizumab, Nilotinib, Nisoldipin, Ranolazin, Tolvantan, Vaccine (Living).

Increasing toxic effects: Dexamethasone can increase the effects of amphotericin B, acetylcholininininiserase inhibitors, cyclosporin, lenalidomids, strap diuretics, natalizumab, thalidomid, nonsteroidal anti-inflammatory drugs (COX-2 inhibitors), non-steroid anti-inflammatory drugs (non-selective), thiazids, residues (live). Warfarin.

The effect of dexamethasone may be increased by :prepitant; asparaginase; Calcium channel blockers (not dihydropyridine); Anti -fungal substances (Azol derivatives, systemic effects); CYP3A4 (medium) inhibitors; CYP3A4 (strong) inhibitors; Estrogen derivatives; Masomacial blocks (non -reducing); P-Glycoprotein inhibitors; Quinolones, Dasatinib; salicylat; trastuzumab.

Dexamethasone can reduce the effect of CYP3A4 substrates, p-glycoprotein substrates; anti -diabetes agents, calcitriol; Caspofungin; corticorelin; dabigatran ether; Everolimus; Isoniazid; Maravires; nilotinib; nisoldipin; Ranolazin; Salicylat; Sorafenib; Tolvantan; vaccine (inactivation).

The effect of dexamethasone may be reduced by: aminoglutethimid; Barbiturat; Bile acid seizures, CYP3A4 (strong) induction substances; P-Glycoprotein induction substances; anti -acid agents; Rifamycin, deferasirox derivatives; Primidon.

Using corticosteroid therapy may need a diet to increase the amount of potassium, vitamin A, vitamin A, C, D, folate, calorpho, zinc and phosphorus and reduce sodium.

Barbiturates, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Ephedrin, Aminoglutethimid may increase corticosteroid removal, so it reduces the treatment effect of the drug.

corticosteroids against the effects of hypoglycemia (including insulin), antihypertensive drugs and diuretics. Corticosteroid increases the hypotension effect of acetazolamid, diuretic thiazids, carbenoxolon.

The effect of anticoagulant cumrica derivatives can increase when used with corticosteroids, so it is necessary to closely check the prothrombin time to avoid spontaneous bleeding.

Salicylate clearance increases when used simultaneously with corticosteroids, so when corticosteroids are susceptible to salicylate poisoning.

Diuretics reduce potassium potassium (for example, thiazid, furosemid) and amphotericin B can increase the effect of reducing potassium potassium of glucorticoid.

To avoid interactions between drugs, notify the doctor or pharmacist about the drugs being used.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.