Dexamethasone/chloramphenicol skin cream, insect bites, contact dermatitis (8g)

Dosage form Bottle
Specifications Dexamethasone acetate, chloramphenicol
Ingredient Resantis Vietnam Branch - Saigon Pharmaceutical One Member Company Limited

Ingredient

Composition information	Content
Dexamethasone acetate	4mg
Chloramphenicol	160mg

Uses

Indication

Dexamethasone/Chloramiphenicol skin cream is used in the following cases:

Skin diseases respond to local corticosteroids and have superinfection such as eczema, insect bites, contact dermatitis, seborrheic dermatitis, atopic dermatitis.

Pharmacokinus

chloramphenicol often has bactericidal effects, but can kill bacteria at high concentrations or for highly sensitive bacteria.

chloramphenicol inhibits protein synthesis in sensitive bacteria by attaching to the mini of the ribosom 50s. The drug has the same position with Erythromycin, Clindamycin, Lincomycin, Oleandomycin and Troleandomycin. Chloramphenicol has almost no effect on Escherichia Coli, Shigella Flexneri, Entobacter spp. Chloramphenicol has no effect on mushrooms.

dexamethason is fluomethylprednisolon, synthetic glucocorticoid. The glucocorticoids act on the receptor in the cell, the transfusion into the cell nucleus and there has affected some of the translated genes. Glucocorticoids also have some direct effects, may not be intermediaries connected to the receptor. Dexamethasone has the main effects of glucocorticoids are anti -inflammatory, anti -allergic and immunosuppressive inhibition, while the effect of electrolyte balance is very few. In terms of anti -inflammatory activity, Dexamethason is stronger than Hydrocortisone, 7 times stronger than prednisolon.

pharmacokinetics

chloramphenicol is quickly absorbed through the gastrointestinal tract.

chloramphenicol is drained mainly in the liver caused by glucuronyl transferase. Chloramphenicol excreted mainly in urine.

Small amount of chloramphenicol in the form of unchanged excretion in bile and stool after taking the drug.

Corticosteroids are well absorbed from the digestive tract, and are also well absorbed at the position of the drug and then distributed into all tissues in the body. Dexamethasone through the placenta and a small amount of milk. Dexamethason also links to plasma proteins (up to 77%) and mainly albumin.

The drug is highly absorbed in the liver, kidneys and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine, most in the form of non -conjugate steroids.

Before taking Dexamethasone/chloramphenicol skin cream, insect bites, contact dermatitis (8g)

How to use

Skin cream cream.

Dosage

Apply thin layer 1-2 times/day.

Do not take more than 8 days for a treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using an overdose? Except for patients who are too sensitive to corticosteroids, causing pathology; At that time, it is necessary to treat symptoms.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

If used for a long time, unwanted side effects may be:

Common

Electrolyte disorders: Hypotension, sodium and edema. Skin atrophy, erythema, him.

urticaria, headache, granulocytopenia, hypoglycemia, hypersensitivity, sometimes anaphylaxis, white blood cells, blood thrombosis, weight gain, appetite, nausea, hard -working, hiccup, sterile abscess.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dexamethasone/Chloramiphenicol skin cream is contraindicated in the following cases:

Systemic fungal infections, local virus infections or tuberculosis, gonorrhea are not controlled by antibacterial drugs.

Be cautious when using

Do not apply thick layer, on a large area, in the icy, eyelid, breast area in nursing women.

Do not apply to the face unless the doctor is indicated.

Local used chloramphenicol can also cause serious harmful reactions so it is necessary to avoid abuse and avoid long -term use.

The effect of drugs on driving and operating machinery

does not affect.

Use drugs for women during pregnancy and lactation

Pregnant women:

Chloramphenicol easily passes through the placenta. Do not use chloramphenicol for pregnant women near the birth period or during labor because it can occur toxic effects on the fetus (for example, gray syndrome is a cardiovascular body that occurs in premature and newborn babies when using chloramphenicol). Glucocorticoid can also inhibit the adrenal glands in babies if the mother uses a prolonged drug.

breastfeeding women:

chloramphenicol is distributed into milk. Be careful for mothers to breastfeed because of the toxic effects on infants and breastfeeding. Dexamethason into breast milk and at risk for breastfeeding.

Drug interaction

No data.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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