Dexamethasone injection solution 4mg/ml Hai Duong treat asthma, severe allergic disease (10 pipes x 1ml)

Used in combination with other treatments in the brain edema, in shock due to many different causes.

Pharmacy

Dexamethason has the main effects of glucocorticoids that are anti -inflammatory, anti -allergic and immunosuppressive inhibitors, while the effect on electrolytes is very small. In terms of anti -inflammatory activity, Dexamethason is stronger than Hydrocortisone, 7 times stronger than prednisolon.

Pharmacological effects: Dexamethasone used body inhibits the pituitary gland release corticotropine (ACTH), causing endogenous adrenal gland shell to secret endogenous corticosteroids (causing secondary adrenal implants). If it is necessary to treat with long -term glucocorticoids, only use the drug at the lowest possible doses and are usually only used as a supportive drug for other treatment. When the body therapy is stopped with pharmacological doses, it is necessary to gradually reduce the dose, until the function of the hill - saddle - adrenal is recovered.

pharmacokinetic pharmacokinetics

absorption and distribution

After injection, dexamethasone sodium phosphate is quickly hydrolysed turned into dexamethasone. After injection of 20 mg of dexamethasone, the peak concentration of the drug in plasma reaches after 5 minutes. Dexamethasone binds to plasma proteins up to 70%, mainly with albumin.

Metabolism and elimination

Selling waste time of plasma in plasma from 3.5 to 4.5 hours but the effect of special drugs lasts longer than the time of the drug exists in plasma, the sale time of the drug in plasma is a bit related to the effect of the drug and the biological waste time of the antidote is more clear about the effect of the drug.

Biological waste time of drugs from 36 - 54 hours. The liver, kidney, adrenal glands are the main organs to tolerate dexamethasone. The drug is slowly metabolized through the liver and excreted mainly through the kidneys largely in the form of non -conjugated steroids. The drug is excreted in the urine.

Relative contraindications: kidney failure, osteoporosis, diabetes, tuberculosis, cardiovascular disease, vein disease.

Caution when using

For patients with infections or suspicion of infection, special attention and treatment with specific antibacterial drugs are necessary first, due to immunosuppressive effects, dexamethasone can cause dramas and spread bacterial infections. However, infected meningitis need to use dexamethason before taking specific antibacterial drugs to prevent encephalitis due to reaction to the bacterial body pieces that have been destroyed by antibacterial drugs.

For people with osteoporosis, or new surgery, mental disorders, peptic ulcer, diabetes, hypertension, heart failure, kidney failure, tuberculosis, it is necessary to closely monitor and actively treat those diseases if needed to use dexamethasone.

The ability to drive and operate machinery

Like other corticosteroids, dexamethasone can cause dizziness. Be sure to make sure the effects of the drug on the body before driving, operate machinery or do any activity that needs alertness. If dizzy occurs, do not drive or operate machinery while taking the drug.

Pregnancy

Dexamethason can easily pass the placenta. That is why the drug is used in obstetrics to promote the growth of the lungs. The use of dexamethasone in the period from 24 to 34 weeks of pregnancy has been shown to promote the development of the fetal lungs and the room of respiratory failure syndrome in infants.

Using dexamethasone before birth can inhibit the development of the fetus, reducing the height, weight and diameter of the fetus's head. The drug can also inhibit the adrenal glands in newborns after the exposure before birth.

If the mother uses high doses of dexamethasone or is taking a prolonged and repeated treatment, it is necessary to monitor the function of the adrenal gland in newborns and the appropriate treatment should be started as soon as the symptom appears.

Breastfeeding period

Dexamethasone can go into breast milk. In case the mother is using high -dose drugs in the whole body for a long time, breastfed babies are at risk of adrenal inhibition.

Be careful when using dexamethasone for nursing women and only use when the drug benefit gives the mother superior to the risk of drugs that may cause children.

Medicinal interaction

Phenytoin, Phenobarbital, Ephedrine, Rifampicin may increase metabolism and elimination of corticosteroids leading to reduced blood medication and biological activity, so corticosteroid dose adjustment. These drug interactions can affect the inhibition test by dexamethasone (DST), which is cautious during the treatment period with the above drugs.

There are reports on false negative effects in Dexamethasone inhibitors (DST) in patients treated with indomethacin. Therefore, the results of the DST should be carefully considered in patients using indomethacin.

Checking prothrombin time regularly in patients using corticosteroids and coumarin anticoagulants at the same time because there are reports on corticosteroids that change the response of anticoagulants. Some studies have shown that the usual effect when using corticosteroids is inhibitors inhibitors to meet Coumarin, although there are conflicting reports.