DH - Captohasan 25 treatments for hypertension, heart failure (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Captopril
Ingredient Heart failure, high blood pressure

Ingredient

Composition information	Content
Captopril	25mg

Uses

indications

DH - Captohasan 25 drugs are indicated in the following cases:

Hypertension. The substance causes strong vessels and stimulates the secretion of aldosteron in the adrenal shell.

In people with high blood pressure, captopril reduces peripheral artery resistance without impacting the heart supply, thus reducing systolic and diastolic blood pressure in both lying and standing positions. Kidney perfusion is maintained or increased slightly, the glomerular filtration level does not change.

Maximum hypotension effect achieved after taking the drug for 60 - 90 minutes, the dosage time depends on the dose, normally about 6-12 hours.

Treatment of hypertension with Captopril improves artery dilatation as well as reducing left ventricular hypertrophy.

In people with heart failure, captopril reduces the burden of burden and burden, increases cardiac supply, thus increases the ability of the heart of people with myocardial infarction, captopril has a synergistic effect with other drugs (medications that soluble thrombosis, beta blockers, Aspirin) to improve mortality and reduce infarction recurrence at all ages, gender, infarction.

Dynamic pharmacokinetics

captopril is quickly absorbed through the gastrointestinal tract, bioavailability reaches about 65 -75%. Food reduces 30-35% of the absorption of the drug but does not affect the treatment effect.

Peak concentration in plasma is achieved within 1 hour. The half -life of the drug is 2 hours.

The ability to bind to plasma proteins is 30%. The distribution volume is 0.7 liters/kg.

About 75% of oral dosage except for the kidneys, of which 50% in non -metabolic form and the rest are metabolites of Captopril Cystein, Captopril Disulfid.

In people with impaired renal function can cause drug accumulation.

Before taking DH - Captohasan 25 treatments for hypertension, heart failure (10 blisters x 10 tablets)

How to use

DH - Captohasan 25 uses oral. Should drink captopril 1 hour before meals.

Time and dose decided by the doctor.

Dosage

adults

Dosage for hypertension treatment:

Starting dose: 12.5 mg x 2-3 times/day.

Maintenance dose: 25 mg x 2-3 times/day.

Maximum dose: 50 mg x 2-3 times/day.

Dosage for heart failure:

Starting dose: 6.25 mg x 3 times/day.

Maintenance dose: 25 mg x 3 times/day.

Dosage to treat left ventricular dysfunction after myocardial infarction:

Start treatment with captopril from the 3rd day after the infarction.

Start with a dose of 6.25 mg/day.

Adjust the dose as directed by the doctor.

Dosage for treating glomerular disease in people with diabetes:

Dosage of treatment: 25 mg x 8 times/day, long -term use.

For patients with renal failure

Creatinin clearance coefficient

(ml/min/m2)

Initial doses (mg/day)

If not achieved after 2 weeks

12.5 mg x 3

25 mg x 3

6.25 mg x 3

25 mg x 3

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms: fever, headache and hypotension.

Treatment: Evaluation treatment affects the tongue, bar or larynx by stopping captopril; subcutaneous adrenalin injection, intravenous diphydramin hydrochloride and hydrocortison; Intravenous naci solution 0.9% to maintain blood pressure. Captopril can be removed by hemorrhage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using DH - Captohasan 25, you may experience unwanted effects (ADR).

Most side effects are dizziness and foreign rash (about 2%).

These reactions often depend on the dose and related to complications such as kidney failure, connective tissue disease in blood vessels.

Common: dizziness, foreign rash, itching, cough.

Uncommon: Hypotenemicary hypotension, stomatitis, gastritis, abdominal pain, epigastric pain, taste change.

Rare:

Systemic: sensitive, urticaria, eosin leukemia, lymph nodes, weight loss.

circulatory: vasculitis.

Endocrine: Big breasts in men.

skin: angioedema, bulging lips, tongue spectrum, hoarseness, limb edema, sensitive light, pemphigus -style rash, diverse roses, stevens syndrome - Johnson, flaking dermatitis. liver: jaundice, pancreatitis.

Respiratory: Short spasms.

Muscle muscle: muscle pain, joint pain.

Neurological: Perception, depression, confusion.

genital, urinary: proteinuria, hyperkalemia, kidney syndrome.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

DH - Captohasan 25 contraindications in the following cases:

Too hypersensitivity to captopril or with one of the other ingredients of the drug.

History of angioedema, after myocardial infarction (if the hemodynamics are unstable).

Narrow renal artery narrowing on both sides or kidney artery in the case of only one kidney.

Aortic narrow or mitral valve stenosis or severe congested cardiac disease.

Pregnant and lactating women, children.

Caution when using

impaired renal function, hemorrhage, dehydration or strong diuretic treatment: The risk of severe hypotension.

Diuretics hyperboly or potassium salts (because captopril has the effect of keeping potassium).

Surgery or anesthesia with drugs that hypoglycemia can lead to a dramatic hypotension caused by captopril causing secondary release.

The risk of increasing anaphylactic reactions when using the enzyme inhibitors simultaneously.

The ability to drive and operate machinery

need to be cautious when taking the drug for Chinese drivers, vehicles, operating machinery and equipment, because the drug can cause dizziness, dizziness for some people.

pregnancy

captopril can cause damage to the fetus and babies when using the drug in the middle 3 months and the last 3 months of pregnancy such as: lowering blood pressure, reducing newborn skulls, recovery or non -recovery and death.

Must stop using captopril as soon as possible after being pregnant.

Not for pregnant women.

Breastfeeding period

Captopril secreted in breast milk, causing many harmful effects for breastfeeding.

Do not use for breastfeeding women.

Interactive drug

should not be used simultaneously captopril with drugs that keep potassium like cyclosporin or diuretics.

With lithium: captopril may increase the explosion of blood lithium leading to lithium poisoning.

Sympathomical bronchodilators, non-steroid anti-inflammatory drugs (NSAID) can reduce the effect of lowering the blood pressure of captopril.

Use captopril simultaneously with diuretics can cause a synergistic effect.

Storage

Where dry, less than 30 ° C, avoid light.

Other drugs

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