DI-ENSEL 8 Roussel Medicine Acute Analgesic Average level (2 blisters x 10 tablets)

Dosage form Hard capsules
Specifications Box of 2 blisters x 10 tablets
Ingredient Paracetamol, codeine

Ingredient

Composition informationContent
Paracetamol500mg
Codeine8mg

Uses

Indications

Di-Ansel 8 is indicated for treatment for patients over 12 years of age to relieve acute pain at an average level when other pain relievers such as paracetamol or ibuprofen (single) are ineffective, with or not hot:

Headache, muscle aches, bone pain, joint pain, back pain, spinal pain, toothpaste, dysmenorrhea, neurological pain, flu pain, sore throat or sinus nose, injury, sprain, postoperative pain (except for surgery at the head, abdominal) ...

Pharmacology

Paracetamol has a peripheral and fever -reducing effect, ATC code: N02be01.

Codeine is a central analgesic with weak effect, code ATC: N02AA59.

Codeine works through μ opioid receptors. However, Codeine has low affinity for these receptors, and the pain relief effect of the drug is due to the transformed codein into morphine. Codeine, especially when coordinated with other painkillers such as paracetamol, has been proven to be effective in analgesic due to acute neurological sense.

Dynamic pharmacokinetics

paracetamol is quickly absorbed through the gastrointestinal tract, which works within 1 hour after drinking, distributed into tissue and body fluid. Metabolic drugs in the liver into the form of glucuronic and sulfonic combinations. The sale time is about 2 hours. Paracetamol is excreted mainly through the renal in the form of metabolism and constant form (

The disposal time of Codeine is 2 - 4 hours. Codeine is metabolized in the liver and eliminated in the kidneys in the form of freely or in combination with glucuronic acid, excreted in stools very little. Codeine through the placenta and a small amount through the blood - brain barrier.

This combination does not see mutual influence in the process of absorption, distribution, elimination between paracetamol and codeine in the body after drinking.

Before taking DI-ENSEL 8 Roussel Medicine Acute Analgesic Average level (2 blisters x 10 tablets)

How to use

oral drugs, adults and children over 12 years old.

Dosage

Adults

Each time from 1-2 tablets, 2-4 times a day. The distance between 2 times of taking medicine is 4 - 6 hours, no more than 8 tablets/day.

Children from 12 - 18 years old

1 tablet each time, the distance between 2 drugs is 6 hours. In case of necessity may increase to up to 8 tablets/day.

Children under 12 years old

Do not recommend pain relief.

In case of severe renal failure, the distance between 2 taken drugs must be longer than 8 hours.

Pain treatment period should be limited to less than 3 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Related to paracetamol

With a dose of 10 g or more can cause liver damage in adults. In the case of patients with risk factors such as long -term treatment with carbamazepin, phenobarbiton, phenytoin or regular drinking; Or the amount of glutathion in the body is exhausted, the amount of 5 g of paracetamol or more can lead to liver damage.

Symptoms of overdose at the first 24 hours: pale, nausea, vomiting, anorexia and abdominal pain. Liver damage appears clearly 12 - 48 hours after drinking. When severe poisoning, liver failure can progress into brain disease, hemorrhage, hypoglycemia and death. Acute renal failure, acute renal necrosis, arrhythmia, pancreatitis or abnormalities in metabolism of glucose may occur.

Regarding codeine

Inhibiting acute respiratory center (blue purple, reducing respiratory frequency), drowsiness, rash.

Handling

Gastric lavage, preferably within 4 hours after drinking.

n-acetylcystein is used by intravenous or taken, preferably within 10 hours after poisoning.

Use methionin, activated carbon and/or salt bleach.

Response respiration by providing controlled oxygen and respiratory support. Naloxon indications immediately by intravenously in severe cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Di-Ansel 8 often experience unwanted effects (ADR).

involves codeine

Unknown frequency

  • Neurological: Drowsy, dizziness.
  • Respiratory: Difficulty breathing.
    • Systemic body: Hypersensitive reaction (itching, urticaria, rash). digestive: constipation, diarrhea, vomiting, acute abdominal pain, especially in people who have passed gallbladder surgery.

    related to paracetamol

    Rare, 1/10,000

  • Body: rash or red skin, or allergic reactions in the form of sudden swelling of the face or neck or suddenly shortness of breath and lower blood pressure.

    • Very rare, ADR

  • Testing: Change test results in people who regularly check blood.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    Di-Answer 8 Contraindicated for use in the following cases:

  • Hypersensitivity to one of the ingredients of the drug.
  • Patients with liver failure and patients with glucose-6-phosphate dehydrogenase (due to paracetamol).
  • Respiratory failure, bronchial asthma (due to codeine).
  • Lactating women.
  • Patients with gene metabolism through CYP2D6 super fast.

    • Children from 0 to 18 years old have just performed tonsils or grated procedures V.A.

    Be cautious when using

    should not be used during treatment with this drug.

    Pay attention to patients in the following cases:

  • There are liver and kidney diseases.
  • There are respiratory diseases (including asthma).

    It is not recommended for children under 12 years of age to treat analgesic, due to the risk of opioid poisoning because of unpredictable changes in the transformation of codeine into morphine.

    Codeine should only be used at the lowest doses that are effective and in the shortest time.

    Codeine is not recommended for children with respiratory function impairment (neuromuscular disorders, severe heart or respiratory diseases, upper and upper respiratory tract infections, multiple trauma or have just undergone major surgery). These factors can worsen the symptoms of Morphin poisoning.

    Contraindicated to patients with gene metabolic gene through CYP2D6 is strong or super fast due to increased risk of harmful reactions caused by Opiod poisoning, even permanent dose. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected.

    Codeine used after children's surgery from 0 to 18 years old has just performed tonsillectomy procedures and/or grated V.A can cause rare harmful reactions, but life -threatening even death. Therefore, contraindicated drugs for these patients.

    Doctors need to warn patients on signs of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

    The ability to drive and operate machinery

    should be careful to use the drug when driving or operating machinery because the drug reduces alertness.

    Pregnancy

    Di-Answer 8 can treat short-term at the recommended dose, if the benefits of the drug surpasses the risks due to the fetus.

    The period of breastfeeding

    In the usual dose of treatment, Codeine and active metabolites may be present in the breast milk at very low doses and does not seem to cause adverse effects on breastfed babies. However, if the patient is a super -fast CYP2D6 metabolic gene, the transformed code into morphine may be in breast milk with higher concentrations and in very rare cases that can lead to symptoms of opioid poisoning in newborns, which can be fatal. Therefore, it is not recommended for breastfeeding women.

    Drug interaction

    related to codeine

    Due to the inhibition of cytochrom P450 enzymes, it reduces cyclosporin metabolism. Used with painkillers, sleeping pills, anti -psychotic drugs, anxiety antidepsus or depression (including alcohol) can add depression, so the dose of these substances must be reduced. Using anti -cholin secretion with codeine can cause intestinal paralysis.

    Related to paracetamol

    Used with anticoagulants (warfarin) increases the effects of anticoagulants.

    • Storage

    Store in a dry place, temperatures below 30 ° C, avoid light.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    count views

    Popular Keywords