Diacerein 50 - HV USP Treatment of osteoarthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Diacerein
Ingredient Osteoarthritis, arthritis, rheumatoid arthritis

Ingredient

Composition information	Content
Diacerein	50mg

Uses

Indications

Diacerein 50 - HV is indicated in the following cases:

Specific long -term oral treatment for osteoarthritis (osteoarthritis and related diseases). Prostaglandin. Diacerein is likely to affect both cartilage assimilation and catabolism and reduce inflammatory factors. Kết quả của một số nghiên cứu in-vitro và in-vivo cho thấy Diacerein và Rhein, một chất chuyển hóa có hoạt tính của nó, ức chế sự sản xuất và hoạt động của chất cytokine IL-1b tiền viêm và tiền dị hóa, cả ở lớp nông và lớp sâu của sụn, trong màng hoạt dịch và dịch màng hoạt dịch trong khi kích thích sự sản xuất yếu tố tăng trưởng chuyển dạng (TGFb ) và các thành phần của chất căn bản ngoài tế bào như Proteoglycan, Aggrecan, Hyaluronic Acid and Type II glue.

In addition, these substances also show inhibition of macrophages and movement of macrophages. Studies in some animal osteoarthritis models show that diacerein reduces cartilage degeneration compared to the untreated group. Clinical studies have shown significant pain relief and significant joint improvement compared to placebo after 1 month of treatment with diacerein. Other studies show that the beneficial effect of Diacerein treatment lasts at least 2 months after stopping treatment. A randomly blind study between the placebo group and the control group, conducted in many centers for 3 years (Ichodiah research) on 507 patients with hip osteoarthritis showed that Diacerein significantly slows down cartilage degeneration.

pharmacokinetic

When taking 50mg twice a day, diacerein is transformed into Rhein before entering the circulatory system. Rhein is eliminated through the kidney (20%) or combined in the liver into Rhein Glucuronide (60%) and Rhein Sulfate (20%), these metabolites are excreted mainly through the kidney.

Diacerein's dynamic characteristics are the same in young, healthy and older volunteers who have normal kidney function when taking single dose (50mg) or restless doses (5 or 75mg twice a day).

Rhein dynamic after taking single dose Diacerein is in the range of 50 to 200mg. However, Rhein dynamics depend on time. The constant concentration is gained after the third dose and the average selling time is then in the range of 7-8 hours. Drink Diacerein along with a standard meal that hinders the absorption into the circulatory system but increases 25% of the absorption.

Before taking Diacerein 50 - HV USP Treatment of osteoarthritis (10 blisters x 10 tablets)

How to use

Take the pills in the main meals.

Dosage

The common dosage: 1 capsule 2 times/day at two main meals for a long time.

Should start treating 1 capsule/day at dinner for 2 weeks because Diacerein can quickly increase the time of food through the intestine for the first 2 weeks of treatment then increase the dose to 2 capsules/day. The beneficial effect is observed after 2-4 weeks of treatment, so it is necessary to encourage patients not to stop treating before the effectiveness of the drug is clearly seen. Due to the slow starting impact (after 2-4 weeks of treatment), and the ability to tolerate very well through the gastrointestinal tract, Diacerein can be combined with an nonsteroidal anti -inflammatory drug or analgesics for the first 2-4 weeks of treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Need symptomatic treatment. If diarrhea lasts, please see your doctor. Emergency treatment includes water -electrolyte recovery if necessary.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Diacerein 50 - FHV, you may experience unwanted effects (ADR).

Increase the food time through the intestines and abdominal pain is the most common side effect during treatment with diacerein. These symptoms may appear in the first few days of treatment and in most cases, these symptoms decrease on their own.

Using diacerein can sometimes make the urine darker. This is a typical sign of the compound in the drug and has no clinical significance.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diacerein 50-HV drug is contraindicated in the following cases:

Patients who know how to be hypersensitivity to the drug or with the excipients of the drug or those who have a history of hypersensitivity to the derivatives of anthraquinone.

Caution when using

kidney failure changes the pharmacokinetics of diacerein, so it should be reduced in these cases (creatinine clearance

Do not simultaneously use laxatives with diacerein 50 - HV.

Do not use for children under 15 years old because there are no clinical studies at this age group.

Should consider the benefits compared to the risk of using diacerein for patients with previous intestinal disorders, especially the colon is easily stimulated.

The ability to drive and operate machinery

Diacerein 50-HV does not affect the ability to drive trains or operate machinery.

Pregnancy

should not be prescribed for pregnant women.

Breastfeeding period

Should not prescribe breast -feeding women because there are reports showing small amounts of diacerein derivatives into breast milk.

Medicinal interaction

Unsuitable with salt, oxide or aluminum hydroxide, calcium and magnesium hydroxide because they reduce the absorption of diacerein. These substances should be used after 2 hours Diacerein.

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoiding light.

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