Dianfagic Minh Hai medicine relieves average or severe pain (20 tablets)

Dosage form Paracetamol, tramadol hydrochloride
Specifications Minh Hai Pharmaceutical Joint Stock Company

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	325mg
Tramadol hydrochloride	37.5mg

Uses

Indications

dianfagic are designated in the following cases:

Analgesic in severe or medium pain. Paracetamol acts on the hypothalamus, causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

With the dose of treatment, Paracetamol only affects cycloyxygenase/prostaglandin of the central nervous system, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding.

Tramadol hydrochloride is an opioid synthetic analgesic with an analgesic effect according to the central mechanism and can be addictive as morphine. O-Desmethyltramadol (M1) drugs of tramadol hydrochloride attached to the receptor μ of neuron neuron and reducing the re-import of norepinephrin and serotonin into the cells should have analgesic effect.

Pain relief effects appear after 1 hour of use and reach the maximum effect after 2-3 hours. Unlike morphine, tramadol hydrochloride does not cause histamine release, does not affect the heart frequency and left ventricle function and at the dose of tramadol hydrochloride treatment less respiratory inhibitors than Morphin.

pharmacokinetics

paracetamol is absorbed quickly and almost completely through the digestive tract. Agricultural peak in plasma is reached within 30-60 minutes after drinking with treatment dose.

Paracetamol is distributed quickly and evenly in most body tissues. About 25% paracetamol in the blood combined with plasma proteins.

Tramadol hydrochloride absorbs well through the gastrointestinal tract, but there is a strong metabolism through the strong liver, so the absolute use of the drug is only 75%. The maximum concentration time in the blood between tramadol hydrochloride and metabolites. Tramadol hydrochloride has a maximum concentration in the blood after use 2 hours, while M1 metabolic products are 3 hours.

The drug is excreted mainly through the kidneys 90% and 10% through the stool, in the form of unprocessed metabolism accounts for 30% and has been metabolized of 60%. The drug goes through the placenta and breast milk. Half of the excretion of tramadol hydrochloride is 6.3 hours and M1 is 7.4 hours.

Before taking Dianfagic Minh Hai medicine relieves average or severe pain (20 tablets)

How to use

oral medication.

Dosage

Dosage and the number of drug use depends on acute or chronic pain. But the best time is no more than 7 days for a batch of treatment.

Adults and children over 15 years old

Take 1-2 capsules/time, 4-6 hours a day without more than 400 mg of tramadol hydrochloride.

For patients with impaired renal function

If the clearinine clearance

If creatinine clearance

For patients with severe liver function impairment

The one -time dose 50 mg, 12 hours/time.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Overdose depends on the dose, often showing: vomiting, convulsions, confusion, anxiety, tachycardia, hypertension, coma, respiratory failure.

Handling

Depending on the degree of overdose, there is different management methods. Firstly maintain good ventilation, active treatment, anti -convulsions with Barbiturat or benzodiazepin derivatives.

If the poisoning is orally, it is possible to drink activated carbon to reduce the absorption of tramadol hydrochloride, but the clinical benefits have not been studied (new research in mice).

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Not determined frequency

Nervous system: convulsions (when overdose), dizziness, drowsiness, sleep, migraine, irritation, tremor, owl, loss of coordination, melancholy, dizziness, fast forgetting, depression, drug dependence, mental.

The immune system: Hypersensitivity.

Respiratory system: Respiratory failure.

Cardiovascular system: suspense, arrhythmia, cyanosis, myocardial ischemia.

ears: tinnitus. general: numbness, fatigue, sweat, loss of sensation.

Urinary system: Difficult, urinary retention, little urination.

Digestive system: Nausea, vomiting, bloating, dry lips.

Muscle system: Increase muscle tone.

Reproductive system: menstruation, menstrual disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Hypersensitivity to drugs or opioids.

Acute poisoning or overdose of central neurological inhibitors such as alcohol, sleeping pills, central analgesics, opioids or mental medications.

People who are taking imao or newly used inhibitors (stopping the drug less than 15 days).

Severe respiratory failure, severe liver failure, children under 15 years old, breastfeeding women.

Untreated epilepsy by treatment.

addicted to opioids.

Be cautious when using

people with a history of anaphylaxis with codeine or other opioids when using tramadol hydrochloride tramadol is likely to be at risk of anaphylaxis.

People with an opioid dependence.

In case it is necessary to coordinate with central neurological inhibitors, the tramadol hydrochloride dose must be reduced.

Although tramadol hydrochloride causes poor respiratory inhibitors, high doses or combined with anesthesia and alcohol, will increase the risk of respiratory inhibitors.

Patients with manifestations of brain pressure or head injury when using tramadol hydrochloride need to monitor mental state carefully.

People with liver and kidney function need to reduce the dose of tramadol hydrochloride.

The risk of drug addiction if used tramadol for more than 7 days is repeated. Patients crave drugs, search for medicine, and increase the dose due to greasy.

The ability to drive and operate machinery

tramadol hydrochloride reduces alertness. Therefore, do not use drugs when driving a train, operating machinery and working on high.

pregnancy

Because the drug passes through the placenta, it is not used before labor or during labor, except for the case of expected effect is really greater than the risk. Pregnant women who use tramadol hydrochloride long -term can be addictive to drug addictive and syndrome for children after birth.

Breastfeeding period

drugs into breast milk. For safety for babies and young children, do not use drugs during breastfeeding.

Drug interaction

Carbamazepin: Increases the metabolism of tramadol hydrochloride.

quinidine: CYP2D6 inhibitors reduce metabolism and increase the effects of tramadol hydrochloride.

Warfarin: Tramadol hydrochloride tramadol prolongs prothrombin time, when used in combination with warfarin, it is necessary to check the regular prothrombin time.

Fluoxetin, paroxetin, aminotriptylin reduces the metabolism of tramadol hydrochloride tramadol, whereas tramadol hydrochloride inhibits the re -import of noradrenalin and serotonin. Therefore, not coordinated in treatment.

Storage

The drug needs to be stored at temperatures below 30 ° C. Cool dry place, avoid light.

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