Diclofen Pharmedic treatment for chronic arthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Diclofenac

Ingredient

Composition information	Content
Diclofenac	50mg

Uses

indications

Diclofen 50 mg is indicated in the following cases:

Long -term treatment: symptoms of chronic rheumatoid arthritis (rheumatoid arthritis, spinal stiffness, chronic osteoarthritis), rheumatism in psoriasis.

diclofenac, which conducts the substance of phenylacetic acid, is nonsteroidal anti -inflammatory drug. The drug has pain relief, anti -inflammatory, antipyretic.

Diclofenac strongly inhibits the activity of cyclooxygenase, thus significantly reducing the formation of prostaglandin, prostacyclin and thromboxan are intermediate substances of the inflammatory process. DiClofenac also regulates the Lipoxygenase path and platelet's collection.

pharmacokinetics

absorption:

Diclofenac is easily absorbed through the gastrointestinal tract after drinking. The drug is absorbed faster if you are hungry.

Distribution:

diclofenac is greatly attached to plasma proteins, mainly with albumin (99%).

Metabolism:

about 50% diclofenac metabolizes the liver for the first time. The maximum concentration of drugs in plasma appears 2 hours after drinking, the concentration in the fluid is the highest level after drinking for 4-6 hours. The effect of the drug appears 60 - 120 minutes after drinking.

Era:

The sale time from the epidemic pack is 3 - 6 hours. About 60% of the dose is discharged through the kidneys in the form of metabolites remaining in part of the activity and 1% in the form of intact drugs, the rest is discharged through bile and feces.

Before taking Diclofen Pharmedic treatment for chronic arthritis (3 blisters x 10 tablets)

How to use

swallow the whole pill with water (no chewing), drink before meals.

Dosage

need to calculate the dose carefully, depending on the needs and response of each individual and the lowest dose needs to use. In long -term treatment, the results mostly appear in the first 6 months and often maintained later.

Attack dose: 1 tablet/time, 3 times a day.

Maintenance dose: 1 tablet/time, 2 times a day.

Dysmenorrhea: 1 tablet/time, 2 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

Diclofenac's acute poisoning: worse side effects.

How to handle:

The common measure is to cause vomiting or gastric lavage immediately, followed by symptomatic and supportive treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Diclofen 50 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

headache, restlessness, epigastric pain, nausea, vomiting, diarrhea, flatulence, anorexia, indigestion, increased transaminase, tinnitus.

Uncommon, 1/1000

edema, allergies, anaphylaxis, rhinitis, urticaria, abdominal pain, gastrointestinal bleeding, progressive ulcer.

vomiting blood, bleeding, drowsiness, falling asleep, depression, insomnia, anxiety, difficulty sleeping, prone to stimulation, bronchospasm, visual disorders.

Rare, ADR

edema, rash, Stevens - Johnson syndrome, hair loss, sterile meningitis.

leukopenia, thrombocytopenia, neutropenia, eosinophilia, granulocytes.

Anemia, gallbladder contraction disorders, abnormal liver function test, liver poisoning.

Cystitis, blood, acute nephritis, interstitial nephritis, nephrotic syndrome.

Instructions on how to handle ADR

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diclofen 50 mg is contraindicated in the following cases:

allergies to diclofenac, aspirin and other nonsteroidal anti -inflammatory drugs.

Progressive stomach ulcer.

People with asthma or bronchospasm, bleeding, cardiovascular disease, severe kidney failure or severe liver failure.

The person who is taking anticoagulants Coumarin.

People with hemolytic heart failure, reduced circulatory volume due to diuretic or kidney failure, glomerular filtration speed

People with glue -generating diseases.

Be cautious when using

people with a history of ulcer, bleeding or puncture of the digestive tract.

Patients with kidney failure, liver failure, lupus erythematosus.

Patients with hypertension or water condition or edema.

People with a history of liver disease. Need to monitor regular liver function when long -term treatment.

The infected person.

People with a history of coagulation disorders, bleeding.

The ability to drive and operate machinery

Caution when driving and operating machinery due to drugs can cause drowsiness, soreness, blurred vision, double look.

Pregnancy

only use diclofenac for pregnant women when really necessary and when the patient cannot use anti -inflammatory drugs of other groups and only use with the lowest dose. Do not take the drug in the last 3 months of pregnancy.

Pregnant women should not use any drugs that inhibit the synthesis of prostaglandin, including diclofenac, because of the embryo inhibitor.

breastfeeding period

diclofenac is secreted in breast milk very little. There is no data on the effect of breastfeeding. Nursing mothers can use diclofenac if needed nonsteroidal anti -inflammatory drugs.

Drug interaction

diclofenac may increase or inhibit the effects of other drugs.

Do not use diclofenac in combination with:

Oral and heparin anticoagulant: The risk of severe bleeding.

Quinolon antibiotics: diclofenac and other nonsteroidal anti -inflammatory drugs can increase side effects on the central nervous system of quinolon antibiotics, leading to seizures (but need further research).

aspirin or glucocorticoid: reduces diclofenac concentration in plasma and increases the risk as well as increases serious stomach damage.

Diflunisal: using diflunisal simultaneously with diclofenac can increase the concentration of diclofenac in plasma, reducing the purification of diclofenac and can cause very severe bleeding in the gastrointestinal tract.

lithium: diclofenac can increase lithium concentration in serum to toxicity. If forced to use simultaneously, it is necessary to monitor the patient carefully to detect the signs of lithium poisoning promptly and to monitor the level of lithium in the blood. Lithi dose must be adjusted during and after treatment with diclofenac. Digoxin: Diclofenac can increase the concentration of Digoxin in the serum and prolong the semi -waste time of digoxin. Digoxin concentration should be quantified and reduced digoxin dose if taken simultaneously both drugs.

ticlopidin: Use with diclofenac increases the risk of bleeding.

The contraceptive device placed in the uterus: Diclofenac may cause contraception.

methotrexate: diclofenac increases the toxicity of methotrexate.

Can use diclofenac along with the following drugs but must monitor the patient closely:

Cyclosporin: The risk of cyclosporine poisoning. Need to regularly monitor the kidney function of the patient.

Diurel: diclofenac and diuretic may increase the risk of secondary kidney failure due to reduced blood flow to the kidneys because diclofenac inhibits prostaglandin.

Hypertension treatment (enzyme inhibitors, β blockers, diuretics).

Using anti -acid drugs can reduce intestinal irritation by diclofenac but can reduce the concentration of diclofenac in serum.

cimetidine can reduce serum diclofenac concentration a bit but do not reduce the anti -inflammatory effect of the drug. Cimetidin protects the duodenum from the harmful effects of diclofenac. Probenecid can make Diclofenac concentration doubled if used simultaneously. This can have good clinical effects in people with joint disease but can occur diclofenac poisoning, especially in people with impaired renal function. The effect of waste uric acid - urinary is not affected. If necessary, reduce the diclofenac dose.

Storage

At a temperature not exceeding 30 ° C.

1981, Pharimex's direct import and export company was established. 1983, transformed into the Pharmaceutical and Pharmaceutical Private Enterprise Pharmedic. 1997, transformed into Pharmedic Pharmaceutical Joint Stock Company. 2002, receiving GMP, GLP, GSP certificates issued by the Ministry of Health. 2003, ISO 9001: 2008 certified by Det Norske Veritas (DNV). 2007, GMP - WHO certificate is granted by the Ministry of Health. 2009, GPP & GPP certificates are received by the Department of Health of Ho Chi Minh City. HCM.

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