Diclofenac 50 Uphace treatment for long -term arthritis, osteoarthritis (100 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Diclofenac sodium
Ingredient Uphace

Ingredient

Composition information	Content
Diclofenac sodium	50mg

Uses

indications

Diclofenac 50mg is indicated for long -term treatment of chronic arthritis, osteoarthritis.

Pharmacokic

diclofenac, derivative of phenylacetic acid is a nonsteroidal anti -inflammatory drug. The drug has anti -inflammatory, analgesic and strong fever.

Diclofenac is a strong active inhibitor of cyclooxygenase, thus significantly reducing the formation of prostaglandin, prostacycline and thromboxan are intermediate substances of the inflammatory process. DiClofenac also regulates the Lipoxygenase path and the platelet aggregation.

pharmacokinetics

absorption:

Diclofenac is easily absorbed through the gastrointestinal tract after drinking. The drug is absorbed faster if taken for hunger.

Distribution:

diclofenac is greatly attached to plasma proteins, mainly with albumin (99%).

Metabolism:

About 50% of oral doses are metabolized through the liver for the first time and bioavailability in the blood circulation is approximately 50% of the bioavailability of intravenous injection. The maximum concentration of drugs in plasma appears 2 hours after drinking, the concentration in the fluid fluid reaches the highest level after drinking from 4 to 6 hours.

The effect of the drug appears 20 - 30 minutes after the intramuscular injection, 30-60 minutes after placing the drug in the rectum, 60 - 120 minutes after taken.

Era:

Half life in plasma is about 1-2 hours. Half life eliminated from the epidemic fluid is 3-6 hours. Approximately 60% of the dose is discharged through the kidneys in the form of metabolites and part of the activity and less than 1% in the form of intact drugs, the rest is discharged through one and feces.

absorption, metabolism and elimination seems to not depend on age. If the dosage and distance between the drug use are followed by instructions, the drug is not accumulated, even if the kidney function and the liver are reduced.

Before taking Diclofenac 50 Uphace treatment for long -term arthritis, osteoarthritis (100 tablets)

How to use

Take before eating.

Swallow the whole pill with water, not remove, crush or chew the pill.

Dosage

To minimize the risk of adverse events, Diclofenac is needed at the lowest daily dose effective in the shortest possible time.

It is necessary to calculate the dose carefully, depending on the needs and response of each individual and the lowest dose is effective. In long -term therapy, the results mostly appear in the first 6 months and are often maintained later.

Degenerative (damaged) joints: 1 tablet/time x 2-3 times/day. Long -term treatment: 2 capsules/ day, divided 2 times; Do not use higher doses.

Rheumatoid arthritis: 1 tablet/time x 3-4 times/day. Long -term treatment of rheumatoid arthritis: The recommended dose is 1 tablet/time x 2 times/day and if needed to increase, up to 4 tablets/day, divided twice.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

The common measure is to immediately cause vomiting or gastric lavage, followed by symptomatic treatment and support. After gastric vomiting and active carbon can be used to reduce the absorption of the drug in the gastrointestinal tract and in the liver cycle.

Diuretics to treat Diclofenac poisoning is a suspicious measure, because the drug is highly attached to plasma proteins; However, diuretic can also be helpful, but if used, it must be closely monitored with water - electrolytes because there may be serious disorders of electrolytes and water stasis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Diclofenac 50mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: headache, restlessness.

digestion: epigastric pain, nausea, vomiting, diarrhea, abdominal distention, anorexia, indigestion. liver: increase transaminase. ears: Tinnitus

Uncommon, 1/1000

Systemic: edema, allergies (especially bronchospasm in patients with asthma), anaphylaxis, including hypotension, rhinitis, urticaria.

digestive: abdominal pain, gastrointestinal bleeding, progressive ulcer, vomiting, diarrhea and blood.

Nervous system: drowsiness, falling, depression, insomnia, anxiety, discomfort, easily stimulated.

skin: urticaria

Respiratory: Bronchospasm.

face: blurred vision, visual dark spot, eye aches, pairing.

Rare, ADR

Body: edema, rash, Stevens - Johnson syndrome, hair loss.

Nervous system: Aseptic meningitis.

blood: leukopenia, platelet reduction, neutropenia, eosinophilia, granulocytosis, anemia. liver: gallbladder contraction disorders, abnormal liver function test, liver toxicity (jaundice, hepatitis).

urinary tract: cystitis, bleeding, acute renal failure, interstitial nephritis, nephrotic syndrome.

Cardiovascular thrombosis: Clinical and epidemiological tests show that the use of diclofenac is associated with increased risk of cardiovascular thrombosis (such as myocardial infarction or stroke), especially when using diclofenac at high doses (150 mg/day) and extended.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diclofenac 50mg contraindicated drug in the following cases:

Hypersensitivity to diclofenac, aspirin or other nonsteroidal anti -inflammatory drugs (asthma, rhinitis, urticaria after taking aspirin).

Progressive stomach ulcer.

People with asthma or bronchospasm, bleeding, cardiovascular disease, severe kidney failure or severe liver failure.

People who are taking anticoagulant drugs.

People with heart failure, reduce the circulatory volume due to diuretic or kidney failure, glomerular filtration speed

Patients with congestive heart failure (from level II to iv according to the functional degree of heart failure according to the New York-aha Heart Association), ischemic heart disease, peripheral artery disease, cerebrovascular disease.

People with adhesive diseases (the risk of sterile meningitis. It should be noted that all cases of aseptic meningitis are in a history of an autoimmune disease, as a factor that is susceptible to the disease).

The person carrying contact lenses.

Caution when using

people with a history of ulcer, bleeding or puncture of the digestive tract.

Patients with kidney failure, liver failure, lupus erythematosus.

Patients with hypertension or heart disease or edema.

People with a history of liver disease. Need to monitor regular liver function when long -term treatment with diclofenac.

The infected person.

People with a history of coagulation disorders, bleeding.

It is necessary to examine the scientific label for patients with visual disorders when using diclofenac.

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), not aspirin, using systemic tract may increase the risk of cardiovascular thrombosis, including myocardial and dull muscle infarction, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient does not have previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear.

To minimize the risk of adverse events, DiClofenac is needed at the lowest daily daily doses that are effective in the shortest possible time.

Consider carefully when using diclofenac for patients with risk factors for significant cardiovascular events (such as hypertension, lipid lipid, diabetes, tobacco addiction).

The ability to drive and operate machinery

The drug can cause some unwanted effects such as headache, drowsiness, falling asleep and affecting vision, so be cautious when used for drivers and operating machinery.

Pregnancy

only use diclofenac for pregnant women when necessary and when the patient cannot use anti -inflammatory drugs of other groups and only use with the lowest dose.

Do not take the drug in the last three months of pregnancy (the risk of uterine inhibition of the uterus contracts and causes the arterius to close early, causing increased pressure on the circulating circulating without recovery, renal failure in the fetus).

Pregnant women should not use any drugs that inhibit the synthesis of prostaglandin, including diclofenac, because of the embryo inhibition.

breastfeeding period

diclofenac is secreted in breast milk very little. There is no data on the effect of breastfeeding. Nursing mothers can use diclofenac if needed nonsteroidal anti -inflammatory drugs.

Drug interaction

diclofenac may increase or inhibit the effects of other drugs.

Do not use diclofenac in combination with:

Oral and heparin anticoagulants: The risk of severe bleeding.

Quinolon antibiotics: diclofenac and other nonsteroidal anti -inflammatory drugs can increase side effects on the central nervous system of quinolon antibiotics, leading to seizures (but need further research).

aspirin or glucocorticoid: reduces the concentration of diclofenac in plasma and increases the risk as well as seriously increases stomach -intestinal damage.

diflunisal: using diflunisal simultaneously with diclofenac can increase the concentration of diclofenac in plasma, reducing the purification of diclofenac and can cause very severe bleeding in the gastrointestinal tract. lithium: diclofenac can increase lithium concentration in serum to toxicity. If forced to use simultaneously, it is necessary to monitor the patient carefully to detect the signs of lithium poisoning promptly and to monitor the level of lithium in the blood. Lithi dose must be adjusted during and after treatment with diclofenac.

Digoxin: Diclofenac can increase the concentration of Digoxin in the serum and half -life of Digoxin. Digoxin concentration is required and weighted dosgoxin dose if taken simultaneously.

ticlopidin: Use with diclofenac increases the risk of bleeding.

The contraceptive device placed in the uterus: There is a document that uses diclofenac that loses the effect of contraception.

methotrexat: diclofenac increases the toxicity of methotrexate.

Can use diclofenac along with the following drugs but must monitor the patient closely:

Cyclosporin: The risk of cyclosporin poisoning. Need to regularly monitor the kidney function of the patient.

Diurel: diclofenac and diuretic may increase the risk of secondary kidney failure due to reduced blood flow to the kidneys because diclofenac inhibits prostaglandin.

Cure hypertension (conversion inhibitors, beta blockers, diuretics).

Using anti -acid drugs can reduce intestinal irritation by diclofenac but can reduce the concentration of diclofenac in serum.

cimetidin can reduce serum diclofenac concentration a bit but do not reduce the anti -inflammatory effect of the drug. Cimetidin protects the duodenum from the harmful effects of diclofenac.

Probenecid can make Diclofenac concentration doubled if used simultaneously. This can have good clinical effects in people with joint disease but can occur diclofenac poisoning, especially in people with impaired renal function. Effect of waste uric acid - urinary is not affected.

If needed, reduce the diclofenac dose.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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