Diclofenac 75 Uphace long -term treatment of chronic arthritis, osteoarthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Diclofenac sodium
Ingredient Powerful edema, dysmenorrhea, migraine, arthritis, rheumatoid arthritis, adolescence arthritis

Ingredient

Composition information	Content
Diclofenac sodium	75mg

Uses

Indications

Diclofenac 75mg drug is indicated in the following cases:

Long -term treatment of chronic arthritis, osteoarthritis.

Pharmacokic

diclofenac, derivative of phenylacetic acid is a nonsteroidal anti -inflammatory drug. The drug has anti -inflammatory, analgesic and fever effect. Diclofenac is a strong active inhibitor of cyclooxygenase, thus significantly reducing the formation of prostaglandin, prostacycline and thromboxan are intermediate substances of the inflammatory process. DiClofenac also regulates the Lipoxygenase path and platelet's convergence.

pharmacokinetics

absorption:

Diclofenac is easily absorbed through the gastrointestinal tract after drinking. The drug is absorbed faster if taken for hunger.

Distribution:

diclofenac is greatly attached to plasma proteins, mainly with albumin (99%). The maximum concentration of drugs in plasma appears 2 hours after drinking, the concentration in the fluid fluid reaches the highest level after drinking from 4 to 6 hours.

Metabolism:

About 50% of oral doses are metabolized through the liver for the first time and bioavailability in the blood circulation is approximately 50% of the bioavailability of intravenous injection. The effect of the drug appears 20 - 30 minutes after the intramuscular injection, 30 - 60 minutes after placing the drug in the rectum, 60 - 120 minutes after drinking.

Era:

Half life in plasma is about 1-2 hours. Half life eliminated from the epidemic fluid is 3-6 hours, approximately 60% of the dose is discharged through the kidneys in the form of metabolites and a part of the activity and less than 1% in the form of intact drugs; The rest is discharged through bile and feces.

absorption, metabolism and elimination seems to not depend on age. If the dosage and distance between the drug use are followed by instructions, the drug is not accumulated, even if the kidney and liver function is reduced.

Before taking Diclofenac 75 Uphace long -term treatment of chronic arthritis, osteoarthritis (10 blisters x 10 tablets)

How to use

Diclofenac 75mg oral orally, swallow pills with water, not break, crush or chew the pill. Drink after eating.

Dosage

need to calculate the dose carefully, depending on the needs and response of each individual and the lowest dose needs to use. In long -term therapy, the results mostly appear in the first 6 months and are often maintained later.

Degenerative (damaged) joints: 1 tablet/time x 2 times/day. Long -term treatment: 1 tablet/time/day; Do not use higher doses.

rheumatoid arthritis: 1 tablet/time x 2 times/day. Long -term treatment of rheumatoid arthritis: The recommended dose is 1 tablet/time/day and if needed, up to 2 tablets/day, divided twice.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The general measure is to immediately cause vomiting or gastric lavage, followed by symptomatic and supportive treatment.

After gastric vomiting and active carbon can be used to reduce the absorption of the drug in the gastrointestinal tract and in the gastrointestinal cycle. Diuretic to treat Diclofenac poisoning is a suspicious measure, because the drug is highly attached to plasma proteins; However, diuretic can also be helpful, but if used, it must be closely monitored with water - electrolytes because there may be serious disorders of electrolytes and water stasis.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Diclofenac 75mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: headache, restlessness.

Digestive: epigastric pain, nausea, vomiting, diarrhea, abdominal distention, anorexia, indigestion.

Liver: Increase transaminase.

ears: tinnitus.

Uncommon, 1/1000

Systemic: edema, allergies (especially bronchospasm in patients with asthma), anaphylaxis including hypotension, rhinitis, urticaria.

Digestive: abdominal pain, gastrointestinal bleeding, progressive ulcers, vomiting, blood, diarrhea.

Nervous system: Drowsy, falling asleep, depression, insomnia, anxiety, discomfort, easily stimulated.

skin: urticaria.

Respiratory: bronchospasm.

Eyes: blurred vision, visual dark spot, eye pain, double look.

Rare, 1/10000

Systemic: edema, rash, Stevens - Johnson syndrome, hair loss.

Nervous system: Aseptic meningitis.

Blood: Reducing white crane, platelet reduction, neutropenia, eosinophilia, granulocytosis, anemia.

Liver: gallbladder contraction disorders, abnormal liver function test, liver poisoning (jaundice, hepatitis).

Urinary: cystitis, hematuria, acute renal failure, interstitial nephritis, nephrotic syndrome.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diclofenac 75mg contraindicated drug in the following cases:

Hypersensitivity to Diclofenac, aspirin or other nonsteroidal anti -inflammatory drugs (asthma, rhinitis, urticaria after taking aspirin).

progressive stomach ulcer.

People with asthma or bronchospasm, bleeding, cardiovascular disease, severe kidney failure or severe liver failure.

The person who is taking anticoagulant drugs.

People with hemolytic heart failure, reduced circulatory volume due to diuretic or kidney failure, renal filtration speed

People with glue -generating diseases (the risk of sterile meningitis, attention should be noted that all cases of aseptic meningitis are in a history of a certain autoimmune disease, as a factor susceptible).

The contact lenses.

Caution when using

people with a history of ulcer, bleeding or puncture of the digestive tract.

Patients with kidney failure, liver failure, lupus erythematosus.

Patients with hypertension or water condition or edema.

People with history of liver disease. Need to monitor regular liver function when long -term treatment with diclofenac.

The infected person.

People with a history of coagulation disorders, bleeding.

It is necessary to examine the science label for patients with visual disorders when using diclofenac.

The ability to drive and operate machinery

The drug can cause some unwanted effects such as headache, drowsiness, drowsiness and image to visual, so be careful when used for drivers and machinery operators.

Pregnancy

only use diclofenac for you to become pregnant when really necessary and when the disease does not use anti -inflammatory drugs of other groups and only use with the lowest dose. Do not take the drug in the last three months of pregnancy (the risk of inhibiting uterus contracts and causes early closed arteriosclerotic, causing increased circulating urine pressure without recovery, renal failure in the fetus).

Pregnant women should not use any drugs that inhibit the synthesis of prostaglandin, including diclofenac, because of the embryo inhibitor.

The period of breastfeeding

diclofenac 75mg is secreted in breast milk very little. There is no data on the effect of breastfeeding. Nursing mothers can use diclofenac if needed nonsteroidal anti -inflammatory drugs.

Drug interaction

diclofenac 75mg may increase or inhibit the effects of other drugs.

Do not use diclofenac in combination with:

Anticoagulants according to oral oral and heparin: The risk of severe bleeding.

Quinolon antibiotics: diclofenac and other nonsteroidal anti -inflammatory drugs may increase side effects on the central nervous system of Quinolon antibiotics, leading to seizures (but need further research).

Aspirin or glucocorticoid: reduces the concentration of diclofenac in plasma and increases the risk as well as seriously increases stomach -intestinal damage.

diflunisal: using diflunisal simultaneously with diclofenac can increase the concentration of diclofenac in plasma, reducing Diclofenac purification and can cause very severe bleeding in the gastrointestinal tract.

Lithi: Diclofenac can increase lithium concentration in serum to toxicity. If forced to use simultaneously, it is necessary to monitor the patient carefully to detect the signs of lithium poisoning promptly and to monitor the level of lithium in the blood. Must adjust the lithium dose during and after treatment with diclofenac.

Digoxin: Diclofenac can increase the serum digoxin level and half -life of Digoxin, need to quantify the concentration of Digoxin in the blood and need to reduce the dose of digoxin if used simultaneously both drugs.

ticlopidin: used with diclofenac increases the risk of bleeding.

The contraceptive device placed in the uterus: There is a document that uses diclofenac that loses the effect of contraception.

methotrexate: diclofenac increases the toxicity of methotrexate.

Can use diclofenac along with the following drugs but must monitor the patient closely:

cyclosporin: The risk of cyclosporin poisoning, regular monitoring of the patient's kidney function.

Diuretic gums: diclofenac and diuretic may increase the risk of secondary renal failure due to reduced blood flow to the kidneys because diclofenac inhibits prostaglandin.

Hypertension treatments (conversion inhibitors, beta blockers, diuretics).

Using anti -acid drugs can reduce the intestinal irritation by diclofenac but can reduce the concentration of diclofenac in serum.

Cimetidine may reduce serum diclofenac concentration but do not reduce the anti -inflammatory effect of the drug. Cimetidin protects the duodenum from the harmful effects of diclofenac.

Probenecid can make Diclofenac concentration doubled if used simultaneously. This can have good clinical effects in people with joint disease but can occur diclofenac poisoning, especially in people with impaired renal function. The effect of waste uric acid - urinary is not affected. If necessary, reduce the diclofenac dose.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.