Diclofenac 75 Vacopharm medicine for long -term treatment of chronic arthritis, osteoarthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Diclofenac

Ingredient

Composition informationContent
Diclofenac75mg

Uses

indications

Diclofenac 75 drug is indicated in the following cases:

  • The long -term treatment of chronic arthritis, osteoarthritis. strong. Diclofenac is a powerful inhibitor of cyclooxygenase, thus significantly reducing the formation of prostaglandin, prostacycline and thromboxan are intermediate substances of the inflammatory process. Diclofenac also regulates the lipooxygenase path and platelet's convergence.

    Diclofenac is damaging the gastrointestinal tract due to decrease in prostaglandin, which leads to mucin inhibitors (substances that protect the gastrointestinal tract). Prostaglandin plays a role in maintaining kidney perfusion. The nonsteroidal anti -inflammatory drugs inhibit prostaglandin should cause interstitial nephritis, glomerulonephritis, papillitis and nephrotic syndrome especially in people with kidney disease or chronic heart failure. For these patients, nonsteroidal anti -inflammatory drugs can increase acute renal failure and acute heart failure.

    pharmacokinetics

    absorption:

    Diclofenac is easily absorbed through the gastrointestinal tract after drinking. The drug is absorbed faster if taken for hunger.

    Distribution:

    diclofenac attaches greatly to plasma proteins, mainly albumin (99%). The maximum concentration of drugs in plasma appears 2 hours after drinking, the concentration in the fluid is the highest level after drinking from 4 to 6 hours.

    Metabolism:

    About 50% of oral dose is metabolized through the liver for the first time.

    Era:

    Half life in plasma is about 1-2 hours. Half life eliminated from the epidemic fluid is 3-6 hours. Approximately 60% of the dose is discharged through the kidneys in the form of metabolites and part of the activity and less than 1% in the form of intact drugs; The rest is discharged through bile and feces.

    absorption, metabolism and elimination seems to not depend on age. If the dosage and distance between the drug use are followed by instructions, the drug is not accumulated, even if the kidney and liver function is reduced.

    • Before taking Diclofenac 75 Vacopharm medicine for long -term treatment of chronic arthritis, osteoarthritis (10 blisters x 10 tablets)

    How to use

    Take the whole pill, do not chew.

    Dosage

    need to calculate the dose carefully, depending on the needs and response of each individual and the lowest dose needs to use. In long -term therapy, the result of the first part appears in the first 6 months and is usually maintained later.

    Degeneration (damage) joints:

    Take 1 capsule/time, 2 times a day.

    Long -term treatment: 1 tablet/day.

    rheumatoid arthritis:

    Take 1 capsule/time, 2 times a day.

    Long -term treatment: 1 tablet/day, can increase 2 tablets/day, divide 2 times.

    Acute pain or prostitute:

    Take 1 capsule/time, 2 times a day.

    To minimize the risk of adverse events, Diclofenac 75 is needed at the lowest daily doses to be effective in the shortest possible time.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Handling: Causing vomiting and gastric wash, followed by symptomatic and supportive treatment. Activated carbon can be used to reduce the absorption in the digestive tract and in the liver cycle.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Diclofenac 75, you may experience unwanted effects (ADR).

    Unknown frequency:

    Nervous system: headache, restlessness.

    Digestive system: epigastric pain, nausea, vomiting, diarrhea, abdominal distention, anorexia, indigestion, stomach ulcers - duodenum, gastrointestinal bleeding.

    Liver: Increase transaminase.

    Cardiovascular system: Increased risk of cardiovascular thrombosis (such as myocardial infarction or stroke), especially when using diclofenac at high doses (150mg/day) and prolonged.

    Other: Tinnitus.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Diclofenac 75 contraindications in the following cases:

  • Patients with hypersensitivity to diclofenac, aspirin or other nonsteroidal anti -inflammatory drugs (asthma, rhinitis, urticaria after taking aspirin).
  • Patients with progressive stomach ulcers, asthma or bronchospasm, bleeding.

    • Cardiovascular disease, severe kidney failure or severe liver failure.

    The person who is taking anticoagulants Coumarin.

    People with hemorrhagic heart failure, reduced circulatory volume due to diuretic or kidney failure, glomerular filtration speed

  • Patients with congestive heart failure (from level II to IV according to the functional degree of heart failure according to the New York Heart Association - NYHA), ischemic heart disease, peripheral artery disease, cerebrovascular disease.

    • People with adhesive diseases: The risk of sterile meningitis. It should be noted that all cases of aseptic meningitis are in a history of an autoimmune disease, as a factor susceptible to the disease.

  • The person carrying contact lenses.

    • Be cautious when using

    people with a history of ulcer, bleeding or puncture of the digestive tract.

    Patients with kidney failure, liver failure, lupus erythematosus.

    Patients with hypertension or water condition or edema.

    Risk of cardiovascular thrombosis:

  • Non -steroid anti -inflammatory drugs (NSAIDs), not aspirin, using systemic sugar can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses. Patients need to be warned of the symptoms of serious cardiovascular events and need to visit the doctor as soon as these symptoms appear. (such as hypertension, increased serum lipid, diabetes, tobacco addiction).

    • People with a history of liver disease. Need to monitor regular liver function when long -term treatment with diclofenac.

    The infected person.

    People with a history of coagulation disorders, bleeding.

    Need to examine the science label for you with visual disorders when using diclofenac.

    The ability to drive and operate machinery

    Caution because the drug can cause visual disorders.

    Pregnancy

    Contraindications for pregnant women in the last 3 months of pregnancy.

    Only use Diclofanac for pregnant women when really necessary and must consider carefully between benefits and risks.

    Breastfeeding period

    Only use Diclofanac for women who are breastfeeding when really necessary and must consider carefully between benefits and risks.

    Drug interaction

    should not use Diclofenac in combination with:

    Oral and heparin anticoagulant: The risk of severe bleeding.

    Increases the assistant effects on the central nervous system of the Quinolon antibiotic.

    Aspirin or glucocorticoid: reduces the concentration of diclofenac in plasma and increases the risk as well as seriously increases stomach -intestinal damage.

    diflunisal: Increased plasma diclofenac concentration, reducing Diclofenac purification and can cause very severe bleeding in the digestive tract.

    Lithi: Diclofenac can increase lithium concentration in serum to toxicity. Must adjust lithium during and after treatment with diclofenac.

    Digoxin: Diclofenac can increase the serum digoxin level and half -life of Digoxin.

    ticlopidin: used with diclofenac increases the risk of bleeding.

    methotrexate: diclofenac increases the toxicity of methotrexate.

    Can use diclofenac along with the following drugs but must monitor the patient closely:

    cyclosporin: The risk of cyclosporin poisoning. Need to regularly monitor the kidney function of the patient.

    Diuretic gums: diclofenac and diuretic may increase the risk of secondary renal failure due to reduced blood flow to the kidneys because diclofenac inhibits prostaglandin.

    Hypertension treatment (enzyme inhibitors, beta blockers, diuretics).

    Using anti -acid drugs can reduce the intestinal irritation by diclofenac but can reduce the concentration of diclofenac in serum.

    Cimetidine may reduce serum diclofenac concentration but do not reduce the anti -inflammatory effect of the drug. Cimetidin protects the duodenum from the harmful effects of diclofenac.

    Probenecid can make Diclofenac concentration doubled if used simultaneously. This can have a good clinical effect in arthritis but can occur in Diclofenac, especially in people with renal function. The effect of waste uric acid - urinary is not affected. If necessary, reduce the diclofenac dose.

    Storage

    Store in a cool, dry place, avoid light, temperature not exceeding 30 ° C.

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