Diclofenac DHG medicine for inflammation and pain in musculoskeletal disorders (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Diclofenac sodium
Ingredient Headache, gout, dysmenorrhea, shoulder dislocations, epidemic inflammation, tendonitis, arthritis, rheumatoid arthritis, spinal pain, sprain

Ingredient

Composition information	Content
Diclofenac sodium	50mg

Uses

indications

Diclofenac DHG drug is indicated for treatment in the case of treatment, the following pain:

Musculoskeletal and joint disorders such as rheumatoid arthritis, osteoarthritis, inflammatory and degenerative forms of rheumatism, pain syndrome of the spine, stiff spine degeneration, dislocated pain, bone pain.

Disorders around the joints such as epidemic inflammation, tendonitis, ...

Soft tissue disorders such as sprains, tendons.

Other cases of pain: back pain, shoulder aches, injury pain, headache, acute gout, dysmenorrhea, menstruality, appendicitis.

Pain after surgery, tooth extraction, tonsillectomy, ...

Reduce symptoms of pain, inflammation with or without fever in the following cases: due to viral infection, bacteria (in the ears, sinus nose, throat, gums, ...).

Pharmacology

diclofenac, the conductivity of phenylacetic acid is nonsteroidal anti -inflammatory drug, has anti -inflammatory, analgesic, antipyretic effect. The active inhibitor of cyclooxygenase, thus significantly reduces the formation of prostaglandin, prostacyclin and thromboxan are inflammatory, pain and fever.

Pharmacokinetics

absorption

DiClofenac dissolves well in intestinal fluid, is easily absorbed through the gastrointestinal tract after oral oral concentration in plasma, highly available.

Distribution

The drug is very strong with plasma proteins (over 99%), mainly with albumin. DiClofenac easily penetrates into the epidemic fluid, the drug concentration here remains while plasma concentrations have decreased.

Metabolism

No information.

Elimination

Half life in plasma is about 1-2 hours. Half life eliminated from the epidemic fluid is 3-6 hours. Approximately 60% of the dose is discharged through the kidneys in the form of metabolic substances (glucuronid and sulphat) and a part of the activity and less than 1% of intact drugs, the rest is discharged through the bile and feces.

The process of absorption, metabolism and elimination of drugs does not depend on age.

Before taking Diclofenac DHG medicine for inflammation and pain in musculoskeletal disorders (10 blisters x 10 tablets)

How to use

diclofenac DHG is a drug that is not broken or crushed when taken.

Dosage

To minimize the risk of adverse events, Diclofenac DHG is needed in the lowest daily daily dose in the shortest time.

Adults

1 tablet/time x 2-3 times/day.

Note: Maximum dose of 150 mg diclofenac sodium/day for any lines.

or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The common measure is to immediately cause vomiting or gastric lavage, followed by symptomatic treatment and support. After gastric vomiting and active carbon can be used to reduce the absorption of the drug in the gastrointestinal tract and in the liver cycle.

Diuretics to treat Diclofenac poisoning is a suspicious measure, because the drug is highly attached to plasma proteins. However, diuretic may also be useful but need to closely monitor water -electrolytes because there may be serious disorders of electrolytes and water stasis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Diclofenac DHG, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: Nausea, vomiting, diarrhea, constipation, epigastric pain.

Uncommon, 1/1000

No information.

Rare, ADR

Gastrointestinal system: ulcers, gastrointestinal bleeding (in the case of prolonged treatment).

Blood: blood disorders (leukopenia, platelets, anemia).

Nervous system: headache, insomnia, easily stimulated.

immune system: urticaria, edema.

Respiratory system: Asthma, bronchospasm.

Eyes: blurred vision, eye pain, double look.

Kidney: Acute renal failure, interstitial nephritis, bleeding.

Liver: Increased liver transaminase, hepatitis.

unknown frequency

Cardiovascular: Increased risk of cardiovascular thrombosis (such as myocardial infarction or stroke), especially when using diclofenac at high doses (150 mg/day) and prolonged.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Diclofenac DHG is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

People with a history of allergies (asthma, rash, acute rhinitis, ...) with prostaglandin inhibitors or acetyl salicylic acid groups.

People with stomach ulcers, duodenum progressive or have a history of gastrointestinal bleeding.

People with bleeding, blood failure, kidney failure or severe liver, reducing the volume of circulatory, people with adhesive diseases.

People who are taking anticoagulant drugs and people wearing contact lenses.

Pregnant women do not use NSAID drugs in the last 3 months of pregnancy.

Patients with congestive heart failure (from level II to IV according to the functional degree of heart failure according to the New York Heart Association - NYHA), ischemic heart disease, peripheral artery disease, cerebrovascular disease.

Caution when using

people with a history of ulcer, bleeding or puncture of the digestive tract.

Patients with kidney failure, liver failure, lupus erythematosus. Need to monitor and test liver and kidney function when treated for a long time with NSAID drugs.

Patients with hypertension or heart disease or edema.

The infected person.

People with a history of coagulation disorders, bleeding.

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), not aspirin, using systemic sugar can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time of medication. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear these symptoms. (such as hypertension, increased serum lipid, diabetes, tobacco addiction).

The ability to drive and operate machinery

Precautions while driving and operating machinery.

Pregnancy

only use drugs for these objects when really necessary. Do not use the drug in the last three months of pregnancy. People who intend to get pregnant should not use diclofenac.

Breastfeeding period

only use drugs for these objects when really necessary.

Drug interaction

should not use Diclofenac in combination with:

Non -steroid anti -inflammatory drugs (NSAIDs), salicylate derivatives, glucocorticoids: increased the risk of ulcers, bleeding in the gastrointestinal tract.

anticoagulant drugs: heparin, courmarin, ticlopidin: increase the risk of bleeding.

Quinolon antibiotic: Increases side effects on the central nervous system of these antibiotics, leading to convulsions.

IUD, capable of reducing contraceptive effect.

lithium, digoxin: diclofenac increases the concentration of these substances in serum to toxicity. If required to coordinate, the lithium, digoxin dose must be adjusted during and after treatment with diclofenac and need to monitor patients carefully about lithium or digoxin concentration in the blood.

can coordinate but must monitor patients:

Cyclosporin: Need to monitor kidney function.

Diuretics: The risk of secondary renal failure due to reduced blood flow to the kidneys.

Medicines for hypertension (transferred inhibitors, beta blockers, ...).

anti -acid drugs: Reducing intestinal irritation by diclofenac but reduces the concentration of diclofenac in serum.

Note when coordinating:

cimetidin: Reduce a little concentration of diclofenac in serum but do not reduce the effect of this drug helps protect the duodenum, stomach avoid side effects of diclofenac.

Probenecid: Increases diclofenac concentration doubled. This has good clinical effects in patients with joints but can occur diclofenac poisoning, especially those with renal function. The effect of waste uric acid - urinary is not affected. If necessary, reduce the diclofenac dose.

Storage

Storage conditions: dry place, temperature not exceeding 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.