Differin Galderma cream treatment acne (30g)

Dosage form Tube
Specifications Adapalene
Ingredient Laboratoires Galderma

Ingredient

Composition information	Content
Adapalene	0.1%

Uses

indicated

Differin Cream is used to treat acne when there are many acne, papules and pustules. The drug can be used for acne on the face, chest and back.

Pharmacological

Adapalen is a retinoid compound that has been shown to be anti -inflammatory properties in vivo and in vitro. Adapalen is sustainable with oxygen, light and no chemical reaction. The mechanism of action of Adapalen, like tretinoin, is to cohesion to the specific retinoic acid receptors of the fertilizer, but different tretinoin is not attached to the protein of the receptor in the cytoplasm.

Adapalen when used on the skin has the effect of eliminating acne in the Rhino mouse model and as well as the effect on the abnormalities of the horny and differentiation of the epidermis, both of these processes are present in the pathogenation of common acne. The method of the impact of adapalen is considered to normalize the differentiation of epithy cyst cells and thus reduces the formation of acne microscopic micro. Adapalen has the advantage of retinoids in the standard anti -inflammatory test both in vito and in vivo.

Its mechanism is inhibiting the dynamic and hyperactive response of multi -core leukocytes and the metabolism by isolation of arachidonic acidization into inflammatory intermediaries. This feature suggests that the intermediate inflammation of acne can be impacted by Adapalen. Human studies have given clinical evidence that adapalen used on the skin is effective in reducing the inflammation of acne (papules and pustules).

Pharmacokinetics

absorption

The drug is absorbed through poor skin. In clinical trials, the adapalen concentration in plasma is not found at a measured level when used long -term on a wide area of acne with analytical sensitivity level of 0.15ng/ml.

Distribution

After processing [14 C] - Adapalen in large mice (intravenous injection, peritoneal injection, oral use), rabbits (intravenous injection, drinking and skin use) and in dogs (intravenous and drinking), radioactive activity distributed in some tissues and are most found in the liver, spleen, adrenal and ovarian.

Metabolism

Animal metabolism in animals has not been clearly defined, mainly through the o-demethylation path, hydroxylation and combination.

Elimination

Mainly excreted drugs via bile.

Before taking Differin Galderma cream treatment acne (30g)

How to use

Gently squeeze the pipe tube at the tail, take a sufficient amount of cream on the fingers to apply to the acne -prone skin. Close the tube lid after use.

Dosage

Differin Cream should be used on acne -prone skin once a day before resting and after washing. A thin layer should be applied, avoiding contact with the eyes and lips (see attention to prevent and be cautious when used). Pay attention to dry the acne -prone skin before applying the drug.

For patients who need to extend the medication distance or temporarily stop treatment, they can be used regularly or continue treatment when considering that the patient can tolerate normal with treatment. If the patient uses cosmetics, cosmetics should not cause acne and not skin astringent.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? If you use too many drugs, you will not get the results faster or better but may be red, peeling or discomfort. Oral toxicity on mice is higher than 10g/kg. However, when swallowing the wrong, unless swallowing only a small amount, it is advisable to consider the appropriate gastrointestinal method.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using 0.1%differin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Skin: There is a sensitive reaction and redness on the skin, peeling or discomfort.

Uncommon, 1/1000

No report.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

hypersensitivity to any ingredients of this drug.

Be cautious when used

If sensitive or severe irritating reactions appear, should stop the drug. If the level of on -site irritation is an alarm, the patient should be instructed to extend the distance of the drug, temporarily stop the drug or stop completely. Differin Cream should not be in contact with the eyes, mouth, nose and mucosa. If the cord is in the eye, wash immediately with warm water.

The ability to drive and operate machinery

Based on the pharmacological and clinical experimental, the ability to drive or operate machines is not affected.

Pregnancy

There is no information on the use of adapalen in pregnant women. Therefore, adapalen should not be used during pregnancy.

The period of breastfeeding

It is unknown whether the drug is secreted through animal milk or human or not. Because many drugs are excreted through breast milk, be careful when using Differin Cream for breastfeeding women. In case of breastfeeding, do not apply to the chest.

Interactive drug

There is no known interaction between other drugs used on the skin at the same time with Differin Cream. However, it is not advisable to simultaneously use retinoid drugs or other drugs with the same method of action with Adapalen.

Adapalene is sustainable with oxygen, light and also has no chemical reaction. While widely researched on animals and people do not show the possibility of the harmful effects of light or allergies to Adapalen's light, the safety of the use of adapalen when exposed to ultraviolet light is not determined on both animals and humans.

Avoid exposure to light or ultraviolet rays. In humans, Adapalene absorbs poorly through the skin and thus interacting with the drug that has almost no whole body. There is no evidence of the influence of the use of differin cream on the skin on oral drugs such as birth control pills and antibiotics.

Differin Cream is capable of causing light -to -off irritation, so it is advisable to avoid simultaneous use with peeling effects, skin sequences or irritating drugs. It is recommended to use Differin Cream 12 hours after using acne treatments on the skin such as erythromycin solution (with up to 4%concentration) or clindamycin phosphate (1%base) or Benzoyl Peroxid gel with up to 10%concentration.

Storage

Store at room temperature (not more than 30 ° C).

Avoid freezing products during transportation and storage.

Leave the medicine out of the reach of children.

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