DIOSFORT SAVI treatment for chronic vein (4 blisters x 15 tablets)

Dosage form Film bag tablets
Specifications Box of 4 blisters x 15 tablets
Ingredient Diosmin
Indication Hemorrhoids, varicose veins lower

Ingredient

Composition information	Content
Diosmin	600mg

Uses

indications

Diosfort drugs are indicated in the following cases:

Treatment of chronic veins leads to varicose veins, veins of the web, edema, deep vein thrombosis, dermatitis, intravenous ulcer and hemorrhoids. At the legs and ankles. Diosmin prolongs the activity of ne due to the inhibition of the decomposition of Ne, Catechol-O-Methyltransferase. Diosmin has also been shown to control lymphatic drainage and reduce edema by increasing CO frequency and amplitude of lymphatic vessels.

Venous hypertension causes increased production of inflammatory factors such as prostaglandin, leukotrien, metalloproteinaise, cytokin, and adhesion molecules. The localized cell gesture to the high concentration of a series of ROS tissue oxidation reactions (Reactive Oxygen Species). Diosmin acts as a substance that cleans up ROS, inhibits 5-lipoxygenase, inhibits the production of Prostaglandin E2 and Thromboxan B2, so it can help protect endothelial cells from being destroyed by acute inflammation or acute oxidant stress.

Pharmacokinetics

absorption

Diosmin is quickly absorbed through the gastrointestinal tract. The peak concentration is achieved after 1-2 hours.

Distribution

The distribution volume is 62.1 liters. It is unknown whether diesmin will be secreted into breast milk.

Metabolism and elimination

The half -life of diosrmin elimination is 31.5 ± 8.6 hours. Under the effects of organisms and intestinal enzymes, Diosmin is hydrolyzed into diosmetin before being absorbed. At the liver, diosmetin is glucuronid before going into the circulatory system. Diosmetin can be converted into hesperetin during the conversion of harmful things under the effect of intestinal bacteria.

Not detected plasma diosmin in animals or humans, in plasma only found the Aglycon form of diosmin is diosmetin, with a peak concentration of 417 ± 94.1 ng/ml after 1 hour, the drug concentration begins to decrease after 2 hours, continuously for 24 hours and after 48 hours still detect drugs in the blood. The lecture product of diosmetin is a phenolic acid excreted in the urine, while diosmin or diosmetin has not been absorbed or not yet metabolized, excreted in feces.

pharmacokinetics of special cases

renal failure: There is no research.

Hepatic failure: No research.

Before taking DIOSFORT SAVI treatment for chronic vein (4 blisters x 15 tablets)

How to use

Take oral use.

The drug must be used as directed by the doctor.

Dosage

adults

Treatment of chronic venous insufficiency such as varicose veins, web veins, edema, stagnant dermatitis and/ or intravenous ulcer: take 1 tablet/ day. Treatment time can be more than 4-8 weeks. For intravenous ulcers, treatment time may take several months.

Treatment of chronic venous insufficiency such as acute hemorrhoids: take 3 capsules/day, divided into 3 times, drink for 4 days. Take 2 capsules/day, divided into 2 times in the next 9 days or as directed by the doctor. After the discomfort during the provincial hemorrhoids has expired, the maintenance dose of 1 tablet/day.

Children

Do not use for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if it is close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Diosfort, you may experience unwanted effects (ADR).

The most common side effect is the reaction on the digestive system including nausea, vomiting, diarrhea, indigestion. The most serious side effect related to Diosmin is the angioedema.

The following unwanted reactions are arranged according to the frequency.

Common, 1/100

Nervous system: Insomnia, dizziness, fatigue, anxiety, cramps, dozing off.

Cardiovascular system: Heart beat fast, hypotension .

Digestive system: Nausea, vomiting, diarrhea , indigestion.

Uncommon, 1/1000

Digestive system: colitis

Nervous system: headache , fatigue, dizziness.

Skin and tissue: rash, itching, urticaria under the skin.

unknown frequency

Thich, face, lips and eyelids.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diosfort medicine is contraindicated in cases where patients are hypersensitively to Diosmin or any ingredient of the drug.

Be cautious when using

Patients using other drugs while being treated with diosmin.

Pregnant women or pregnancy plans.

Women who are breastfeeding.

People with a history of cancer.

The efficiency and safety of Diosmin has not been set up in my children. So do not use Diosmin for children.

The ability to drive and operate machinery

No report.

Pregnancy

Pregnant women should not use diosmin. It is necessary to notify the doctor if you are pregnant or planned to get pregnant.

Demonstrate period

Because there is no data on the distribution of drugs in breast milk, women who are breastfeeding should not use Diosmin. Need to consult a doctor before taking the medication.

Drug interaction

Patients should notify the doctor if they are taking the drugs: chlorzoxazon , diclofenac and Metronidazole (Diosmin significantly reduced the half -life of excretion and AUC value of chlorzoxazon, may be due to the effect on the enzyme metabolized.The same phenomenon occurs with Diclofenac and Metronidazol, both of which are metabolized by CYP2C9 enzymes.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

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