Diouf Davipharm drugs treat severe depression, panic disturbance (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Escitalopram
Ingredient Anxiety, depression

Ingredient

Composition information	Content
Escitalopram	10mg

Uses

indications

DIOF 10 mg drug is indicated in the following cases:

Treatment of severe depression.

Treatment of whole anxiety disorders.

Treatment of panic disorders with or without fear syndrome.

Obsessive fear of society.

Treatment of rapist obsession.

Pharmacology

Escitalopram selectively inhibits the reabsorption of serotonin (5 - HT) neuron neuron central and increases serotonin activity. It has weak effects on the recovery of norepinephrine and dopamine.

The drug starts to work after 1-2 weeks.

Pharmacokinetics

absorption

Absorb almost completely and regardless of food. The average TMAX is 4 hours after repeated dose. Absolute bioavailability of about 80%.

Distribution

The appointed distribution volume after drinking is about 12 - 26 l/kg. Under 80% of the EscitalPram and its main metabolites are associated with plasma proteins.

Metabolism

EscitalPram is metabolized in the liver into Demethyl and Didemethylation substances. Both have pharmacological activity. Both initial substances and metabolites excreted glucuronid. After repeated dose, the average concentration of Demethyl metabolites and Didemethylation is about 28 - 31% and less than 5% of Escitalopram concentration. Biological metabolism of EscitalPram into Demethyl metabolic substance is mainly through CYP2C19 intermediaries. There may be the contribution of CYP3A4 and CYP2D6.

Elimination

The sale time after repeated dose is about 30 hours and the plasma clearance is about 0.6 l/min. The main metabolites have a very long selling time. The drugs and main metabolites are eliminated through both the liver (metabolism) and the kidneys, with the majority of the dose excreted through the kidneys in the form of metabolites.

drugs with linear pharmacokinetics. The constant concentration in plasma is achieved after about 1 week and has an average value of about 50 nmol/l (20 - 125 nmol/l) achieved at a daily dose of 10 mg.

In the elderly, eliminating drugs more slowly and AUC is about 50% higher than normal people.

In patients with mild and medium liver failure, the sale time is about twice longer than 2 times and AUC is about 60% higher than normal.

Before taking Diouf Davipharm drugs treat severe depression, panic disturbance (2 blisters x 14 tablets)

How to use

Take medicine with water.

Dosage

depression, anxiety disorders, rape obsessions

10 mg 1 time/day. Increase the dose if necessary, up to 20 mg once a day.

panic disadvantages

Adults: 5 mg/day, increasing the dose to 10 mg/day after 7 days. Maximum 20 mg/day.

Elderly: Half adult dose.

Hepatic failure: Starting 5 mg/day, depending on the response can increase to 10 mg/day after 2 weeks. Closely monitor patients with severe liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Symptoms

Stunned, coma, convulsions, insomnia, nausea, vomiting, tachycardia sinus button, ECG transformation (extending QT, Twisted Peak).

Handling

Set up and maintain adequate ventilation. You can wash your stomach or use activated carbon. Cardiovascular monitoring, signs of survival and supportive treatment. Diuretic, hemolysis, dialysis or blood transfusion often does not work.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using 10 mg diouf, you may experience unwanted effects (ADR). Often occurs in 1-2 weeks of treatment and decrease when continuing treatment.

Common, ADR> 1/100

vomiting;

Increase or decrease appetite; Lows ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diouf 10 mg is contraindicated in the following cases:

Hypersensitivity to Escitalopram or any ingredients of the drug.

Used with Mao inhibitors.

Used with pimozid.

Be cautious when used

Interactive likely death (serotonin syndrome) with Mao or Linezolid inhibitors.

Perseveres depression and the appearance of suicidal or abnormal changes in behavior may occur in adults and children with depression disorders or other mental disorders, with or not taking antidepressants. Antidepressants can worse depression and appear suicidal ideas and behaviors in some patients in the early stages of treatment. Therefore, all patients taking antidepressants must be closely monitored by signs of severe illness, intentions or suicide behaviors, or abnormal behaviors, especially during the dose adjustment stage.

Reveal bipolar disorder clearly. Used to screen patients at risk for detailed mental history before starting treatment. Escitalopram is not approved to treat bipolar disorders.

There is a cessation syndrome (agitation, anxiety, dizziness, headache, insomnia ...) when taking evacopram and other Serotonin reabsorption inhibitors, especially when stopping the drug suddenly. Need to reduce the dose slowly and monitor the symptoms during the stopping process.

There is an abnormal bleeding (gastrointestinal bleeding) in patients using Escitalopram. Notify patients on the risk of bleeding when simultaneously used for EscitalPram and aspirin or NSAIDs, Warfarin or drugs affecting blood clotting.

Anti -fitting hormone secretion syndrome (SIADH) or hyponatremia that needs medical intervention or stopped Escitalopram.

The drug can affect awareness and exercise.

Be cautious with people with a history of epilepsy and a history of manic.

Caution in patients with myocardial infarction, unstable heart disease, patients with metabolic and hemodynamics change. Precautions in pregnant women, lactating, liver failure, kidney failure, children under 18 years old.

The ability to drive and operate machinery

The drug is at risk of affecting the ability to drive and operate machinery, need to be cautious when taking the drug.

pregnancy

Data using drugs during pregnancy is limited. Do not take medicine for pregnant women.

Breastfeeding period

Do not take medicine for breastfeeding women.

Interactive drugs

Serum concentration can be reduced when used with enzyme induction drugs CYP2C19 (Carbamazepin, Rifampin, Phenytoin) or CYP3A4 enzyme (Nafcillin, Nevirapin). Serum concentration can be increased when used with enzyme inhibitors CYP2C19 (fluconazole, fluvoxamine, omeprazol) or CYP3A4 enzyme (Azol antifungal, clarithromycin). The drug may increase the serum concentration of Despiramin, Metoprolol.

Increased risk of bleeding when used simultaneously with aspirin, nsaids, medications affecting blood clotting.

Pharmaceutical interactions (causing serotonin syndrome) when concurrent use with receptors 5 - HT (Almotriptan, Eletriptan, Frovatriptan ...). If shared, clinical safety, careful monitoring, especially when starting treatment, when increasing the dose or starting another serotonergic drug.

Concentrated with imao can lead to serious side effects. Only start using Escitalopram after stopping Imao for at least 2 weeks and vice versa. Simultaneous use of moclobemid may increase the risk of serotonin syndrome.

Linezolid: Serotonin syndrome is reported.

Selective Serotonin Restrain Inhibitors and Serotonin and Epinephrine Restrain Inhibitors: Selective: capable of causing serotonin syndrome, not recommended for common use.

EscitalPram is the isomers of racemic citalopram, not sharing 2 drugs.

lithium: enhance the effect of serotonergic of evacopram and can cause serotonin syndrome. Precautions when using.

can cause serotonin syndrome when using other drugs or herbs that affect serotonin neurotransmitters (tramadol, st. John wad). Do not encourage the sharing of serotonin money (tryptophan).

Contraindications to EscitalPram with pimozid due to increased QT.

There may be pharmacological interaction with other nervous systems.

Not recommended to use with alcohol.

Increase AUC and plasma concentrations of citalopram when used simultaneously with cimetidine.

Storage

Store in a dry place, avoid light, not more than 30 ° C.

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