Diropam 50mg ENLIE medicine treats symptoms of fake angina, delirium (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Tofisopam
Ingredient ENLIE Pharmaceutical Joint Stock Company

Ingredient

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Composition information	Content
Tofisopam	50mg

Uses

indications

Diropam drugs are indicated in the following cases:

Mental diseases (nerves) and the entities have anxiety, plant disorders, lack of vitality and/or motivation, indifference, fatigue, depression.

Treatment of fake angina symptoms. When muscle relaxants are contraindicated, such as in mechanical diseases, muscle disease, and muscle atrophy.

Pharmacological group: anti -anxiety drugs, Benzodiazepine derivatives.

Tofisopam is a weak anti -anxiety drug with short -effect time, with a wide treatment index. The exact mechanism of effect of the drug is not known much. Tofisopam is different from the classic 1.4 benzodiazepine in terms of chemical structure and physical and clinical characteristics. The drug is effective in treating anxiety with plant symptoms, fatigue and indifference. The drug does not have the usual sleeping effect of the classic benzodiazepine, as well as the no activity of muscle relaxation or anti -convulsions. The drug does not weaken the intellect and physical ability of the patient, in addition to the drug with mild stimulation. Tofisopam has very low toxicity, and only has mild side effects.

There is no physical or mental dependence whether it is long -term treatment.

pharmacokinetics

Tofisopam is quickly absorbed in the digestive system.

Maximum concentration in plasma is reached within 1 - 1.5 hours. 50% of the drug is attached to the protein of plasma. After being absorbed, the drug is strongly metabolized in the liver (the first passing effect) by the main transformation path is to remove methyl.

About 60% of the amount of drugs introduced in the urine and 40% in the form of metabolism. Biological destruction time is 6 - 8 hours.

Prelise clinical safety data:

In animal tests, it does not see the teratogenic effect.

Based on experimental data, the drug does not affect the ability to conceive, nor does it cause mutations or cancer.

Before taking Diropam 50mg ENLIE medicine treats symptoms of fake angina, delirium (2 blisters x 10 tablets)

How to use

oral tablets. Take the tablet with a glass of water. Dosage

The usual dosage in adults: 1 to 2 tablets, 1 to 3 times a day (total 50 mg to 300 mg per day).

If you use it sometimes, you can drink 1-2 capsules.

can start treatment at any appropriate dose. Often there is no need to gradually increase the dose because the drug is well tolerated and does not reduce alertness during treatment with diripam.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

symptoms:

The effects of the central nervous system only appears after high doses (50 - 120 mg/ kg of weight). These doses can cause symptoms of vomiting, confusion, coma, respiratory failure and/or epilepsy.

Management:

Do not vomit when the central nervous system is clearly thought. However, the stomach can be washed. Activated carbon and laxatives can help prevent drug absorption. Flumazenil can be used as an antagonist, but it is best to avoid it if overdose is due to a combination of Tofisopam with 3 -round antidepressants. It is best to avoid being used when hypersensitivity to benzodiazepine or flumazenil, or if the patient has epilepsy. Basic physiological parameters must be monitored, along with appropriate symptomatic treatment. It is also possible to support steaming with Flumazenil treatment for patients with respiratory failure. Do not use the central nervous system stimulants.

Hematuria treatment with additional intravenous fluids and hold patients in Trendelenburg.

If these measures do not recover normal blood pressure, dopamine or noradrenalin can be used. Disciplining and causing no benefit.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using diripam drugs, unwanted effects (ADR) may be experienced (ADR) such as:

Often light and transient, most appear when taking high doses.

The digestive system: eat appetite, constipation, flatulence, nausea, vomiting, dry mouth. Sometimes jaundice can occur from cholestasis. Sometimes it can be confused and can cause seizures in patients with epilepsy.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Diropam drugs contraindicated in the following cases:

Hypersensitivity to the active ingredient or other ingredients of the drug, or any other benzodiazepine.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Do not take the drug in the first three months of pregnancy and when breastfeeding.

Be cautious when treating patients with chronic respiratory failure, or in a history of acute respiratory failure.

Very cautious when using diripam tablets for elderly patients, intellectual retardation and people with renal and/or liver failure, because these people are more susceptible to side effects than other patients.

Medications that impair the central nervous system (such as alcohol, antidepressants, antihistamine, sedation causes sleep, mental disorders, analgesic like opium, anesthetic): When combining these drugs with diripam, it can increase the effects.

Do not take the drug in cases of chronic psychosis as well as in fear or obsession. Using drugs in these cases may increase the risk of suicide and have aggressive attitudes. Therefore, Diropam should therefore be in case of depression, and depression comes with anxiety. Be cautious when treating patients with personality loss.

Be cautious when treating patients with brain physical damage (such as arteriosclerosis).

Diropam treatment can cause seizures in patients with epilepsy.

Do not use this drug for patients with glaucoma angle.

Each diripam tablet contains 92 mg of lactose. Pay attention to this when treating patients without lactose.

Advise patients to avoid alcoholic drinks during treatment with Diropam.

The effect of the drug on the ability to drive and operate machinery

Although diropam does not cause drowsiness or sedation, the patient is not allowed to drive, operate machinery or do jobs at high risk, at least at the beginning of treatment with Diropam. After that, the level and time limit these activities must be decided in each case one.

Using drugs for women during pregnancy and lactation

Pregnant women: Tofisopam passes through the placenta. Contraindicated drugs for the first three months of pregnancy, and must evaluate the dangerous techniques before deciding to take the drug in the later period of pregnancy.

breastfeeding: The drug is eliminated into breast milk, so it should not be used during breastfeeding.

Interactive drug

Medications that impair the central nervous system (such as painkillers, anesthetics, antidepressant, antihistamine H1, sedation causing sleep, mental disorders): Memoram of diropam with these drugs will increase the effects of both (such as sedative effects, respiratory impairment).

Liver enzyme induction substances (alcohol, nicotine, barbiturate, epilepsy medicine): These drugs can increase the metabolism of Tofisopam. This can lead to plasma concentrations and the treatment effect of the drug reduced.

Some fungal medications (ketoconazole, iTraconazole): These drugs can inhibit the metabolism of Tofisopam. Beton blockers can inhibit the metabolism of the drug, although it is not important in terms of clinical.

Digoxin: Tofisopam can increase the concentration of digoxin in plasma.

Warfarin: Benzodiazepine may affect Warfarin's anticoagulant effect.

disulfiram: long -term treatment with this drug can inhibit metabolism of Tofisopam.

antacids: can affect the absorption of Tofisopam. Cimetidine and omeprazole inhibit the metabolism of Tofisopam.

Oral contraceptives: can inhibit the metabolism of Tofisopam.

Alcohol: Tofisopam reduces the effect of the central nervous system of alcohol.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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