Dismolan CPC1HN solution of mucus in viscous mucus (4 blisters x 5 tubes)

Dosage form Oral solution
Specifications Box 4 blister x 5 tubes x 10ml/tube
Ingredient N-acetylcystein

Ingredient

Composition information	Content
N-acetylcystein	200mg

Uses

Indications

dismolan is used in the following cases:

Mucus mucus in mucus (mucoviscidosis) (pancreatic fibrosis), respiratory disease with mucus as mucous as in acute and chronic bronchitis, and regular cleaning in the trachea.

Acetylcystein (N - Acetylcystein) is the N - Acetyl derivative of L - Cystein, a natural amino - acid.

Acetylcystein is used as a mucus and antidote when paracetamol overdose. The drug reduces the mucus in pus or not by separating the disulfua bridge in mucoprotein and facilitates the expansion of the cough, the posture or the mechanical method.

Acetylcystein is used to protect against toxicity of the liver due to paracetamol overdose, by maintaining or restoring the liver's glutathion concentration is the essential substance that causes the active active substance to metabolize the intermediate of paracetamol toxic to the liver. In the overdose of Paracetamol, a large amount of this metabolite is created because of the main metabolic line (Glucuronid and Sulfat) into saturated.

Acetylcystein converts into cystein stimulating glutathion synthesis and therefore, acetylcysteine can protect the liver if they start treatment within 12 hours after paracetamol overdose. Start treatment as soon as possible.

pharmacokinetic

absorption

After drinking, Acetylcystein is quickly absorbed in the digestive tract.

Metabolism

Acetylcysteine has acetyl liver into cysteine and then converted. Achieving plasma peaks between 0.5 to 1 hour after taking the dose of 200 to 600 mg. Biological use when drinking low and may be due to metabolism in the intestinal wall and initial metabolism in the liver.

Elimination

Kidney clearance can account for 30% of the whole body clearance. Selling time for 6.25 hours after drinking.

Before taking Dismolan CPC1HN solution of mucus in viscous mucus (4 blisters x 5 tubes)

How to use

Dismolan is used by oral. Break the plastic tube and drink directly in the tube.

Dosage

Muc mucus:

Adults: 1 tube 10ml x 3 times/day.

Children from 2 to 6 years old: 1 tube 10ml x 2 times/day.

Paracetamol detoxification:

The first dose of 140mg/kg, followed by 70mg/kg, drink every 4 hours, total 17 times. Acetylcysteine is notified very effectively when used within 8 hours after paracetamol overdose. The effectiveness after that time, but recently said that the treatment is up to 24 hours later.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Other symptoms include respiratory failure, hemolysis, scattered blood clotting and kidney failure. Deaths have occurred in patients with overdose acetylcystein while treating paracetamol poisoning. Treatment of overdose as symptoms.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Dismolan, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: Nausea, vomiting.

Uncommon, 1/1000

Neurological: Drowsy, headache. Tinnitus.

Ear Nose Throat: stomatitis, a lot of runny nose.

Body: rash, urticaria.

Rare ADR

Respiratory: Bronchospasm with anaphylactic reaction.

Systemic: fever, chilling.

Instructions on how to handle ADR

The diluted acetylcystein solution may reduce the possibility of vomiting due to drugs. Anaphylactic reaction must be treated immediately by subcutaneous injection adrenalin (0.3 - 0.5ml of 1/1000 solution) 100%oxygen breathing, intubation if needed, intravenous fluid to increase plasma volume, inhalation of Beta - adrenergic -controlled drug owner if bronchospasm, intravenous injection of Hydrocortison or 125mg methylprednisolone.

can inhibit the hypersensitivity reaction to acetylcysteine including body rash, itching, nausea, vomiting, dizziness, using anti -antihistamine first. There is an opinion that hypersensitivity is due to the allergic mechanism on the basis of histamine release rather than the immunity.

Because the hypersensitivity reaction has occurred up to 3% of acetylcystein intravenous people to treat paracetamol overdose, physicians should pay attention to use antihistamine to prevent that reaction diphendramine.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dismolan drugs contraindicated in the following cases:

Children under 2 years old.

Patients with hypersensitivity to acetylcysteine and any ingredients of the drug.

Patients with a history of asthma (risk of bronchospasm with all forms of drugs containing acetylcysteine).

Caution when using

must closely monitor patients at risk of asthma, if using acetylcysteine for people with a history of allergies; If there is bronchodial spasm, bronchodilator spraying must be used as Salbutamol (beta - 2 selective adrenergic drugs, short effects) or ipratropium (antacistic drugs) and must stop acetylcysteine immediately.

When treated with acetylcystein, there may be a lot of diluted phlegm in the bronchi, need to be smoked to remove if the patient reduces cough.

The ability to drive and operate machinery

Caution when driving and operating machinery.

Pregnancy

Paracetamol overdose treatment with acetylcystein in pregnant women is effective and safe, and has the ability to prevent liver toxicity in the fetus as well as in the mother.

Breastfeeding period

Safe drug for breastfeeding.

Medicinal interaction

acetylcysteine is a reducing agent that is not suitable for oxygen - chemicals.

Do not simultaneously use other cough pills or any drugs that reduce bronchial secretion during acetylcysteine treatment.

Storage

Storage in closed packaging, avoid moisture, avoid light, temperature below 30 ° C.

Other drugs

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