Dispatalin Retard Abbott Treatment of Pain due to digestive dysfunction and biliary tract (30 tablets)

Dosage form Hard capsules
Specifications Box of 3 blisters x 10 tablets
Ingredient Mebeverin hydrochlorid

Ingredient

Composition information	Content
Mebeverin hydrochlorid	200mg

Uses

Indications

Dispatalin is indicated in the following cases:

Treatment of abdominal pain and muscle spasticity, colon disorders and discomfort in the small intestine due to irritable bowel syndrome.

Mebeverine is a muscle spasms that work directly on the stomach -intestine smooth muscles without affecting the normal peristalsis of the intestine.

Do not know the exact impact mechanism of the drug, but the multi -mechanical -acting mebeverine, such as reducing the permeability of ion channels, prevents Noradrenalin reabsorption, local pain relief, changes in water absorption. Maybe these effects have contributed to the local effect of Mebeverine on the digestive tract.

Through these mechanisms, Mebeverine has anti -spasms that leads to normal chemistry of intestinal motility without reducing the gastrointestinal tone. There are no side effects of sympathetic system.

Safety and clinical effectiveness

Safety and clinical effectiveness of different forms of Mebeverine are evaluated in more than 1500 patients. The significant improvements on the outstanding symptoms of irritable bowel syndrome (eg painful, fertilizer properties) are generally monitored from reference documents or from clinical clinical studies with control.

all the forms of Mebeverine are generally safe and well tolerated at the recommended dose.

Children

Clinical trials in the form of capsules are only performed in adults. Safety data and clinical effects from clinical trials as well as post -marketing experiences with the form of chaos of Mebeverine Pamoate in patients over 3 years old have shown that Mebeverine is effective, safe and well tolerated.

Clinical studies with distributed Mebeverine have shown that Mebeverine effectively improves symptoms of irritable bowel syndrome in children. More expanded, theoretical theoretical studies have a disperse dispersed mebeverine that confirms the effectiveness of the drug.

Dosage table for capsules is calculated based on consistent safety and good tolerance ability of Mebeverine.

pharmacokinetics

The following detailed description shows how the active ingredient of the dispatalin is metabolized in the body. Ask your doctor if you need to be explained.

absorption

Mebeverine is absorbed quickly and completely after taking tablets. Prolonged release dosage allows the dose of treatment 2 times daily.

Distribution

The accumulation of drugs does not make sense after using multiple doses.

Biological metabolism

Mebeverine Hydrochloride is mainly metabolized by esters, the first step is hydrolyzed into veratric acid and mebeverine alcohol. The main metabolites in plasma are DMAC (carboxylic acid that reduced methyl).

The sale time is in a stable state of DMAC of 5.77 hours.

During the dosage period (200mg B.I.D.), the cmax of DMAC is 804ng/ml and TMAX is about 3 hours. The relative biological available of the long -lasting release capsules is optimized with an average rate of 97%.

Elimination

Mebeverine is completely metabolized but not excreted; The metabolites are almost completely eliminated. Veratric acid is eliminated through urine, the Mebeverine Alcohol is also eliminated through the urine, partly in the form of carboxylic acid (Mac) and partly in the form of carboxylic acid reduced methyl (DMAC).

Children: No pharmacokinetic studies have been conducted in children with any Mebeverine preparatory form.

Before taking Dispatalin Retard Abbott Treatment of Pain due to digestive dysfunction and biliary tract (30 tablets)

How to use

If you have any questions, ask your doctor or pharmacist.

Should take medicine with enough water, at least 100ml of water. Do not chew the tablet because the bag has the purpose to ensure the long -lasting release mechanism.

Dosage

Adults

A capsule, 2 to 3 times daily. Should take medicine with a cup of water before eating.

Do not chew the tablet because the layer has the purpose to ensure the long -lasting release mechanism.

Special subjects

There are no studies on the dosage in the elderly, patients with liver failure and/or renal failure. There is no specific risk for the elderly, patients with liver failure and/ or kidney failure can be found from post -marketing data.

Therefore, there is no need to adjust the dose on the elderly, patients with liver failure and/or kidney failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms: In the case of diffatalin overdose, symptoms are not appeared or mild and return to normal quickly. The stimulating central nervous system may occur (theoretically). The overdose symptoms are nervous and cardiovascular status.

Handling: No specific antidote is known. Treatment of symptoms, recommendations. Gastric lavage should only be considered in the case of serious overdose symptoms detected within 1 hour. The absorption reduction measures are not necessary.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Like other drugs, Dispatalin may have side effects. If you see any side effects are not mentioned in this tutorial, or any side effects become serious, immediately notify your doctor or pharmacist.

Unwanted effects are spontaneously reported from the process of using the Marketing. An exact frequency cannot be estimated from available information.

Mainly allergic reactions, but not excluded, the tracking is limited to the skin.

Skin and tissue disorders

Rash (urticaria), sudden swelling of the face (edema), swelling in the neck or leg (angioedema), skin rash/acne (foreign rash).

immune system disorders

Allergic reactions (hypersensitivity) (anaphylactic reaction).

Report harmful reactions

Reports on harmful reactions after the licensed drug is very important. It allows continuous control of the balance of the benefits and risks of the drug. Health workers are required to report to local regulatory agencies when there is any harmful reaction.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dispatalin drugs are contraindicated in cases of allergies (hypersensitivity) to any component of the drug.

Be cautious when using

No.

The ability to drive and operate machinery

There is no research on the effects on the ability to drive and operate machinery. Description of pharmacokinetics and pharmacological learning as well as post -marketing experience does not show the harmful effects of Mebeverine with the ability to drive and operate machinery.

Pregnancy and lactation

Ask the advice of a doctor or pharmacist before taking any drug during pregnancy or nursing.

Pregnancy

Only a very limited amount of information about using mebeverine in pregnant women. Animal studies are not enough to have reproductive toxicity. Do not use Dispatalin if you are pregnant.

Breastfeeding period

Not known as Mebeverine or its metabolites are secreted through breast milk or not. The excretion of Linebeverine through breast milk has not been studied on animals. Do not use dispatalin during breastfeeding.

fertility

There is no clinical data showing the effects of Mebeverine on the fertility of men or women. However, the studies available on animals do not show harmful effects.

Medicinal interaction

Please inform your doctor or pharmacist if you are or have recently taken any other drugs including non -prescribing drugs.

There are no interactive studies conducted except for alcohol. In vitro and vivo studies on animals show that there is no interaction between Dispatalin Retard and Ethanol.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

Disclaimer

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