Disthyrox Ha Tay medicine replaces or supplements for hypothyroidism (100 tablets)

Dosage form Box of 5 blisters x 20 tablets
Specifications Levothyroxine
Ingredient Goiter

Ingredient

Composition information	Content
Levothyroxine	100mcg

Uses

indications

Disthyrox drugs are indicated in the following cases:

Alternative or supplements for hypothyroidism syndrome due to any reason at all ages (including in pregnant women), except for temporary hypothyroidism during the recovery of semi -acute hypothyroiditis.

coordinated with anti -thyroid drugs in armor poisoning. This combination to prevent goiter and hypothyroidism. On the market is a synthetic preparation.

The main hormone 2 hormone is thyroxin (T4) and triiodothyronin (T3). The amount of T3 and T4 released from the normal thyroid gland during the circulation and is regulated by thyrotropin (TSH) secreted from the anterior pituitary lobe. TSH's excretion is regulated by T4 and T3 levels and the release of thyrotropine (TRH) secretion from the hypothalamus. Recognizing this complex reverse air conditioning system is an important thing in the diagnosis and treatment of armor disorders.

The main pharmacological effect of exogenous thyroid hormones is to increase the metabolism speed of body tissues, helping to regulate the development and differentiation of cells. Children with this hormone deficiency will grow slowly; Slowly mature skeletal system and many other parts of the body. Especially slowly reinforcing bone heads, slow growth and brain development. These pharmacological effects manifest at intermediate cell level, mainly through triiodothyronin; Most triiodothyronin originated from thyroxin through iodine reduction in peripheral tissues.

thyroid hormone increases oxygen consumption in most tissues and increases basic metabolic speed and sugar, lipid and protein metabolism. Thus, hormones have strongly impacted all organs and especially important to the development of the central nervous system. The thyroid hormone also proved to work directly to tissue, such as increasing myocardial contractions.

Mechanism of action

Levothyroxin synthetic in levothyrox has the same effect as natural hormones mainly excreted by the thyroid. It is transformed into T3 at peripheral agencies and as hormones, promoting its specific effects at T3 receptor. The body cannot distinguish external and endogenous levothyroxin.

Dynamic pharmacokinetics

levothyroxin absorbed in the ileum, nodes and a little in the duodenum. Absorption ranges from 48% to 79% depending on a number of factors. Increasing absorption. Under absorbent syndrome, as well as nutritional factors (soy milk, simultaneous use of anion exchange resin such as cholestyramin), which is lost through feces.

Over 99% of the hormone circulating with plasma proteins, including globulin globulin (TBG), albumin and albumin bonding thyroxin (TBPA and TBA) have different affection depending on the hormone. L - Thyroxin (T4) has a stronger linkage than L - Triiodothyronin (T3) in both circulatory blood and on the cell, which explains the prolonged effect of hormones.

The half -life of T4 plasma is 6-7 days, and T3 is 1 day. The half -life of T4 and T3 decreases in hyperthyroidism and increases in people with hypothyroidism. T3 and T4 are associated with glucuronic and sulfuric acid in the liver and excreted into bile.

Before taking Disthyrox Ha Tay medicine replaces or supplements for hypothyroidism (100 tablets)

How to use

Take orally by swallowing all pills with a small amount of water in the morning, when the stomach is empty, at least 2 hours before breakfast.

Children take the medicine at least 2 hours before the first meal of the day. Soak the tablet with a little water for the drug to dissolve and become a smooth mixture (only done for each drink). Then give children a little more water.

Dosage

Light thyroid failure in adults

Initial dose: 50 micrograms/day, drink once. Increasing daily dose from 25 - 50 micrograms in a period of 2-4 weeks until the desired response.

In heart disease, the starting dose of 25 micrograms/day or 50 micrograms 2 days/1 time. Then adjust the dose every 4 weeks and add 25 micrograms until the treatment results are achieved. In people without heart disease, it is possible to quickly reach the maintenance dose (100 - 200 micrograms) after adjustment according to clinical assessment.

heavy thyroid failure in adults

Starting dose: 12.5 - 25 micrograms/day/day. Increase 25 micrograms at daily dose in a period of 2-4 weeks until the desired response.

Maintenance dose: Drink from 75 - 125 micrograms/day drink 1 time.

Elderly thyroid failure

Initial dose: 12.5 - 25 micrograms/day/day.

increasing dose gradually: within 3-4 weeks until the desired response.

Adult dose, maintenance treatment: 100 - 200 micrograms/day, may be higher depending on the patient.

Replace dosage treatment for children under 1 year of age: 25 - 50 micrograms/day/day.

Replacement dose for children over 1 year: 3 - 5 micrograms/kg/day. The dose increases gradually until the dose of adults is about 150 micrograms/day, reaching at the beginning or between the teenage age. Some children may need a higher maintenance dose.

can also be used as follows:

0 - 6 months: 25 - 50 micrograms or 8 - 10 micrograms/kg/day.

6 - 12 months: 50 - 75 micrograms or 6 - 8 micrograms/kg/day. 1 - 5 years old: 75 - 100 micrograms or 5 - 6 micrograms/kg/day.

6 - 12 years: 100 - 150 micrograms or 4 - 5 micrograms/kg/day.

over 12 years: over 150 micrograms or 2 - 3 micrograms/kg/day.

Treatment of congenital hypothyroidism (dull) in healthy infants, full months

37.5 micrograms/day/day (from 25 - 50 micrograms).

Premature babies, weighing less than 2 kg, babies are at risk of heart failure

Start 25 micrograms/day, increase to 50 micrograms/day for 4-6 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Causes a state of metabolic increase similar to endogenous armor poisoning. Signs and symptoms are as follows: Losing weight, increasing appetite, hitting chest drums, restlessness, diarrhea, abdominal spasms, sweating, rapid growth, hypertension, arrhythmia, vibration, insomnia, fear of heat, fever, menstrual disorders. Symptoms are not always clear, maybe many days after taking medicine to appear.

Handling

levothyroxin should be reduced or temporarily suspended if signs and symptoms of overdose appear. If an acute overdose, symptomatic treatment and immediately support. The purpose of treatment is to reduce the absorption in the gastrointestinal tract and prevent the effect on the central and peripheral nervous system, mainly the effects of increasing sympathetic activity.

Can wash stomach immediately or vomit without other contraindications (coma, convulsions, vomiting reflexes). Cholestyramin or activated carbon is also used to reduce the absorption of levothyroxin. Give oxygen and maintain ventilation if needed. Use beta - adrenergic blockers, for example propranolol to prevent many effects increasing sympathetic activity.

Propranolol intravenous injection 1 - 3 mg/10 minutes or take 80 - 160 mg/day, especially when there is no contraindication. Can use heart glycosides if congested heart failure appears. It is necessary to take measures to control fever, hypoglycemia, dehydration when needed. Glucocorticoids should be used to inhibit the conversion from T4 to T3. Because T4 bonds a lot of protein, very few drugs are excluded by fertilizer.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Disthyrox, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Symptoms of hyperthyroidism: weight loss, chest drum, nervous, easy to stimulate, diarrhea, abdominal spasms, sweating, tachycardia, arrhythmia, angina, tremor, headache, insomnia, no heat, fever.

Uncommon, 1/1000

Hair loss.

Rare, ADR

allergies.

Increased metabolism, heart failure.

osteoporosis.

Causes the skull in children early.

fake in children's brain.

Instructions on how to handle ADR

Stop using the drug. With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticoid ...).

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Disthyrox drugs contraindicated in the following cases:

Toxicity due to untreated thyroid and acute myocardial infarction.

adrenal failure has not been adjusted because of increasing adrenal hormone needs in tissues and can cause acute adrenal insufficiency.

Caution when used

is very cautious when used for people with cardiovascular disease and hypertension.

Disclosure in chest pain and other cardiovascular diseases need to reduce the dose.

In people with diabetes or diabetes or adrenal impairment, the treatment of levothyroxin will increase the symptoms. The adjustment of treatment measures properly in these hormonal diseases is essential. Sealed coma must be used with glucocorticoids.

In children, using overdose causes early joints.

If used in combination with oral anticoagulants, regular prothrombin should be checked to determine whether or not to adjust the dose or not.

The ability to drive and operate machinery

Do not use drugs when driving and operating machinery. The side effects of the drug cause excitement, tachycardia, insomnia that affects the nervous system.

pregnancy

thyroid hormones are not easy through the placenta fence. No effect on the fetus when the pregnant mother uses thyroid hormone. The treatment is still continued for women with thyroid disabilities because during pregnancy, the demand for levothyroxin may increase. The dose adjustment should be periodically tested by checking the concentration of TSH in serum.

breastfeeding period

Small amount of thyroid hormone is excreted in milk. The drug does not cause harmful effects on children and does not cause tumors. However, it is necessary to be cautious when taking medicine for breastfeeding women.

Drug interaction

corticosteroid

The clearance through the metabolism of corticosteroids decreases in patients with hypothyroidism and increased hyperthyroidism, so it can be changed along with a change in the thyroid. Must do the dose must be based on the results of the thyroid function assessment and the clinical status.

amiodaron

Amiodaron used alone can cause hyperthyroidism or hypothyroidism.

anticoagulant, COMARIN or Indanodion derivatives

The effect of oral anticoagulants may be affected, depending on the patient's thyroid state. When increased the dose of thyroid hormones may need to reduce anticoagulant dose; Adjust the anticoagulant dose based on prothrombin time.

anti -diabetic drugs and/or insulin

The thyroid hormone can increase insulin or anti -diabetic drugs. Careful monitoring of diabetes control, when starting or when changing or stopping thyroid treatment.

Beta blocker - Adrenegic

The effect of some of these drugs decreases when the patient has hypothyroidism again.

Cytokin (Interferon, Interleukin)

can cause both hypothyroidism and hyperthyroidism.

Cardiac glycosides

The effect of these drugs may be reduced. Digitalis concentration in serum can be reduced in hyperthyroidism or in patients with hypothyroidism back to normal.

ketamin

Causes hypertension and tachycardia if used simultaneously with levothyroxin.

maprotilin

Risk of arrhythmia can increase.

Sodium iodid (123i and 131i)

Radioactive ionic absorption may be reduced.

somatrem/somatropin

Simultaneous use with too much thyroid hormone can quickly bone bone. Untreated hypothyroidism can affect the growth of these 2 drugs.

Theophylin

Theophylin's clearance decreases in people with hypothyroidism and returns to normal when the thyroid gland returns to normal.

3 -round antidepressants

Sometimes it will increase the effect and increase the toxicity of both drugs, possibly due to increased sensitivity to catecholamine. The effect of three -round depression can come sooner.

Popolytic nerve medicine

Simultaneous use may increase the risk of coronary artery failure in patients with coronary artery.

Storage

Leave a cool place, avoid light, temperature below 300C.

Other drugs

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